1. Cell Cycle/DNA Damage
  2. Antifolate
  3. Aminopterin

Aminopterin (Synonyms: 4-Aminofolic acid; APGA)

Cat. No.: HY-14518
Handling Instructions

Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.

For research use only. We do not sell to patients.

Aminopterin Chemical Structure

Aminopterin Chemical Structure

CAS No. : 54-62-6

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10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
5 mg USD 65 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
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Description

Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia[1][2].

In Vitro

The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM[2].
Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes[4].

Molecular Weight

440.41

Formula

C₁₉H₂₀N₈O₅

CAS No.

54-62-6

SMILES

NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[[email protected]@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Aminopterin4-Aminofolic acid APGAAntifolateleukemicleukocytesfolicacidtetrahydrofolicanticancerimmunosuppressiveInhibitorinhibitorinhibit

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