Aminopterin (Standard)
Aminopterin (Standard) is the analytical standard of Aminopterin. This product is intended for research and analytical applications. Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 54-62-6
- 分子式: C₁₉H₂₀N₈O₅
- 分子量:440.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-14518
AminopterinFolic Acid/DHFR Antagonist -
HY-10446
PralatrexateDihydrofolate Reductasean Inhibitor -
HY-10219
RapamycinmTOR Inhibitor -
HY-10820
Pemetrexed -
HY-13664
Folinic acid calciumBiological Folic Acid -
HY-14519
MethotrexateDihydrofolate Reductase Inhibitor -
HY-18062
PyrimethamineDHFR Inhibitor -
HY-B0080
Folinic acid calcium salt pentahydrateEndogenous Metabolite -
HY-14519A
Methotrexate disodiumDihydrofolate Reductase Inhibitor -
HY-10219G
Rapamycin (GMP)mTOR Inhibitor -
HY-10219R
Rapamycin (Standard)Reference Standard -
HY-13781
Pemetrexed disodium hemipenta hydrateAutophagy Inducer
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 54-62-6
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分子量 440.41
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分子式 C₁₉H₂₀N₈O₅
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SMILES
NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1
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別名
4-Aminofolic acid (Standard); APGA (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. MEYER LM, et al. Aminopterin, a folic acid antagonist, in the treatment of leukemia. Am J Clin Pathol. 1949 Feb;19(2):119-26. [Content Brief]
[2]. Rosowsky A, et al. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem. 2004 Dec 30;47(27):6958-63. [Content Brief]
[3]. Gebhardt DO, et al. The influence of aminopterin on limb regeneration in Ambystoma mexicanum. J Embryol Exp Morphol. 1966 Aug;16(1):143-58. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Aminopterin (Standard) 関連分類
HY-14518R 関連分類
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