Search Result

Results for "

acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1185) Apical Sodium-Dependent Bile Acid Transporter (1) Fatty Acid Synthase (FASN) (5) Free Fatty Acid Receptor (6) G protein-coupled Bile Acid Receptor 1 (7) Hydroxycarboxylic Acid Receptor (HCAR) (1) 11β-HSD (2) 5-HT Receptor (6) Acetyl-CoA Carboxylase (5) Acyltransferase (2) ADC Cytotoxin (1) ADC Linker (5) Adenylate Cyclase (2) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (3) Angiotensin-converting Enzyme (ACE) (7) Antibiotic (11) Antifolate (3) AP-1 (1) Apelin Receptor (APJ) (1) Apoptosis (42) Aryl Hydrocarbon Receptor (1) ASCT (2) ATP Citrate Lyase (1) Autophagy (11) Bacterial (58) Biochemical Assay Reagents (25) Bombesin Receptor (1) Calcium Channel (7) CaMK (1) Cannabinoid Receptor (3) Casein Kinase (2) Caspase (4) Cathepsin (2) CCR (1) CD73 (1) CGRP Receptor (2) Chloride Channel (1) Cholecystokinin Receptor (5) Cholinesterase (ChE) (4) Complement System (1) COMT (3) COX (8) CXCR (1) Cytochrome P450 (8) DNA Stain (8) DNA-PK (2) DNA/RNA Synthesis (15) Dopamine Receptor (2) Dopamine Transporter (2) Drug Metabolite (8) EAAT (4) Elastase (1) Endogenous Metabolite (136) Endothelin Receptor (2) Epoxide Hydrolase (3) ERK (1) FAAH (5) FABP (1) FATP (1) Ferroptosis (3) FGFR (2) FLAP (1) Fluorescent Dye (57) Fungal (10) FXR (6) G-quadruplex (1) GABA Receptor (14) Gap Junction Protein (1) GCGR (4) GLP Receptor (3) Glucosidase (4) GLUT (1) GPR84 (1) Guanylate Cyclase (1) HBV (1) HCV (1) HDAC (5) Histamine Receptor (8) Histone Demethylase (2) Histone Methyltransferase (2) HIV (7) HMG-CoA Reductase (HMGCR) (1) HSP (1) HSV (1) iGluR (8) Influenza Virus (4) Insulin Receptor (1) Integrin (2) Interleukin Related (3) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (7) Keap1-Nrf2 (1) Leukotriene Receptor (2) Liposome (12) Lipoxygenase (4) LPL Receptor (4) LXR (1) mAChR (3) MAGL (3) MCHR1 (GPR24) (1) MDM-2/p53 (2) Melanocortin Receptor (2) mGluR (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (6) Mitophagy (1) MMP (2) Molecular Glues (1) Monoamine Oxidase (3) mTOR (1) nAChR (1) NF-κB (2) NKCC (1) NO Synthase (3) Nucleoside Antimetabolite/Analog (3) Orexin Receptor (OX Receptor) (2) Orthopoxvirus (2) Oxytocin Receptor (1) P-glycoprotein (1) P2Y Receptor (2) p38 MAPK (2) p97 (1) Parasite (12) PARP (1) PD-1/PD-L1 (2) PDHK (1) PGE synthase (1) Phosphatase (4) Phosphodiesterase (PDE) (6) Phospholipase (4) PI3K (4) PKA (4) PKC (8) Potassium Channel (11) PPAR (5) Prostaglandin Receptor (8) Protease Activated Receptor (PAR) (2) Proteasome (3) Protein Arginine Deiminase (1) Proton Pump (15) Pyruvate Kinase (1) Raf (1) RAR/RXR (11) Ras (1) Reactive Oxygen Species (6) ROCK (5) ROR (4) ROS Kinase (1) RSV (1) SARS-CoV (2) Secretin Receptor (2) Ser/Thr Protease (3) Sirtuin (1) Small Interfering RNA (siRNA) (1) Sodium Channel (1) Somatostatin Receptor (2) STAT (2) Stearoyl-CoA Desaturase (SCD) (3) Tau Protein (2) Telomerase (1) TET Protein (1) TMV (1) TNF Receptor (2) TOPK (2) Topoisomerase (1) TRP Channel (5) TrxR (1) Tryptophan Hydroxylase (1) Tyrosinase (4) URAT1 (5) Vasopressin Receptor (4) VEGFR (1) Virus Protease (1) Wnt (1) Xanthine Oxidase (6) β-catenin (1)
By Research Areas:	Cancer (163) Cardiovascular Disease (54) Endocrinology (30) Infection (95) Inflammation/Immunology (147) Metabolic Disease (211) Neurological Disease (117)
Click Chemistry:	Labeling and Fluorescence Imaging (4) Azide (9) Alkynes (17)

2045

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

1367

Peptides

Inhibitory Antibodies

213

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas

HY-12489

Ponceau S acid Red 112	Fluorescent Dye	Others
Ponceau S (Acid Red 112) is the most commonly used stain for Western blotting. Ponceau S is applied as an acidic aqueous solution. Ponceau S is compatible with antibody-antigen binding, and stains the proteins on the membrane red.

HY-D0430

Acid Red 249

Tracid Brilliant Red B
Fluorescent Dye Others

Acid Red 249 (Tracid Brilliant Red B) is a kind of weak acid dye containing sulfate ion.

Acid Red 249 Tracid Brilliant Red B	Fluorescent Dye	Others
Acid Red 249 (Tracid Brilliant Red B) is a kind of weak acid dye containing sulfate ion.

HY-D0505A

Eosin Y disodium acid Red 87	Fluorescent Dye	Others
Eosin Y (disodium) is a soluble acid red dye molecule. Eosin Y has a wide application in organic synthesis as a photoredox catalyst.

HY-P0041A

F992 TFA

Vasopressin Receptor Neurological Disease

F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
HY-P0041

F992

Vasopressin Receptor Neurological Disease

F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
HY-P5161A

FC382K10W15 TFA

GCGR Metabolic Disease

FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research.

F992 TFA	Vasopressin Receptor	Neurological Disease
F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.

F992	Vasopressin Receptor	Neurological Disease
F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.

FC382K10W15 TFA	GCGR	Metabolic Disease
FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research.

HY-P3462

Cagrilintide	CGRP Receptor	Metabolic Disease
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.

HY-P3462A

Cagrilintide acetate	CGRP Receptor	Metabolic Disease
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.

HY-P3143

BMSpep-57	PD-1/PD-L1	Cancer
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs.

HY-P3143A

BMSpep-57 hydrochloride	PD-1/PD-L1	Cancer
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs.

HY-P1162

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin SKF 100273	Vasopressin Receptor	Metabolic Disease
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist.

HY-P4895

(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin	Oxytocin Receptor	Neurological Disease
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) is an oxytocin receptor antagonist. (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin can be used for the research of neurological disease.

HY-W037451

Methyl L-leucinate	Amino Acid Derivatives	Others
Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule.

HY-W291634

H-D-Glu-OtBu hydrochloride

Amino Acid Derivatives Others

H-D-Glu-OtBu (hydrochloride) is a glutamic acid derivative.
HY-N9140

Hulupinic acid

Others Others

Hulupinic acid is a prominent oxidation product of hop acids.

H-D-Glu-OtBu hydrochloride	Amino Acid Derivatives	Others
H-D-Glu-OtBu (hydrochloride) is a glutamic acid derivative.

Hulupinic acid	Others	Others
Hulupinic acid is a prominent oxidation product of hop acids.

HY-N11420

Coronatine	Bacterial	Others
Coronatine is a plant growth regulator produced by Pseudomonas syringae. Coronatine simulates bioactive jasmonic acid (HY-122464A) conjugates or octadecanoid signal molecules of higher plants to make plants appear pathogenic symptoms. Coronatine promotes the virulence of Pseudomonas syringae in plants by activating the signal cascade that inhibits the accumulation of Salicylic acid (HY-B0167).

HY-W016012

Glu-Glu	Amino Acid Derivatives	Others
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption.

HY-126172

9-Anthryldiazomethane

Fluorescent Dye Cancer

9-Anthryldiazomethane is a fluorescent labeling reagent, which can be used for detecting fatty acids and derivatives.

9-Anthryldiazomethane	Fluorescent Dye	Cancer
9-Anthryldiazomethane is a fluorescent labeling reagent, which can be used for detecting fatty acids and derivatives.

HY-W399297

Isodeoxycholic acid 7α,12α-Dihydroxycholanoic acid	Endogenous Metabolite	Metabolic Disease
Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is the 3β-epimer of ursodeoxycholic acid. Isodeoxycholic acid has the effect on choleresis and liver biochemistry.

HY-W016330

H-His(1-Me)-OMe

Amino Acid Derivatives Others

H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis.
HY-30216A

Leucic acid

α-Hydroxyisocaproic acid
Endogenous Metabolite Others

Leucic acid is an amino acid metabolite.
HY-W048209

Fmoc-Lys(Palmitoyl)-OH

Amino Acid Derivatives Others

Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis.

H-His(1-Me)-OMe	Amino Acid Derivatives	Others
H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis.

Leucic acid α-Hydroxyisocaproic acid	Endogenous Metabolite	Others
Leucic acid is an amino acid metabolite.

Fmoc-Lys(Palmitoyl)-OH	Amino Acid Derivatives	Others
Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis.

HY-P2976

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid.

HY-W041988

Fmoc-Glu-OMe	Bacterial	Infection
Fmoc-Glu-OMe, a glutamic acid derivative, shows antibacterial activity and gelation property in AgNO₃ solution. Fmoc-Glu-OMe is a mouldable wound healing biomaterial.

HY-P4146

Survodutide

BI 456906
GLP Receptor Metabolic Disease

Survodutide is an glucagon and glucagon-like peptide 1 (GLP-1) receptor agonist.

Survodutide BI 456906	GLP Receptor	Metabolic Disease
Survodutide is an glucagon and glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-P10031

SAR441255	GCGR GLP Receptor	Metabolic Disease
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys.

HY-P4146A

Survodutide TFA BI 456906 TFA	GLP Receptor	Metabolic Disease
Survodutide (BI 456906) (TFA) is an glucagon and glucagon-like peptide 1 (GLP-1) receptor agonist Survodutide (TFA) is equivalent to Survodutide HY-P4146.

HY-151931

JA-ACC Jasmonyl-ACC	Others	Metabolic Disease
JA-ACC (Jasmonyl-ACC) is a derivative of 1-aminocyclopropane-1-carboxylic acid (ACC). ACC is the direct precursor of the plant hormone ethylene. JA-ACC inhibits root growth in Arabidopsis and the inhibition is independent of jasmonic acid (JA) signaling.

HY-N8268

Nordeoxycholic acid 3α,12α-Dihydroxynorcholanic acid	Others	Metabolic Disease
Nordeoxycholic acid is a 23-carbon bile acid. Nordeoxycholic acid is a norcholic acid metabolite and a steroid human metabolite.

HY-N8621

(11S)-(-)-Hydroxyjasmonic acid	Others	Others
(11S)-(-)-Hydroxyjasmonic acid is a hydroxylated cyclopentane fatty acid of the jasmonic acid type that can be found in the culture filtrate of the fungus Botryodiplodia theobromae<.

HY-143787

ALOX15-IN-1	Lipoxygenase	Inflammation/Immunology
ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with _IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively.

HY-143791

ALOX15-IN-2	Lipoxygenase	Inflammation/Immunology
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with _IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively.

HY-N0169B

Murideoxycholic acid

Endogenous Metabolite Metabolic Disease

Murideoxycholic acid is a 6 beta-hydroxylated bile acid.

Murideoxycholic acid	Endogenous Metabolite	Metabolic Disease
Murideoxycholic acid is a 6 beta-hydroxylated bile acid.

HY-P3823A

Asp-Asp-Asp-Asp-Asp-Asp TFA	Influenza Virus	Infection
Asp-Asp-Asp-Asp-Asp-Asp TFA is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.

HY-N11909

8-O-4,8-O-4-Dehydrotriferulic acid

Others Others

8-O-4,8-O-4-Dehydrotriferulic acid is a dehydrotriferulic acid that can be isolated from saponified corn bran insoluble fiber.

8-O-4,8-O-4-Dehydrotriferulic acid	Others	Others
8-O-4,8-O-4-Dehydrotriferulic acid is a dehydrotriferulic acid that can be isolated from saponified corn bran insoluble fiber.

HY-112653A

(±)8-HETE	Endogenous Metabolite	Metabolic Disease
(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).

HY-B1024

DL-Panthenol DL-Pantothenol; DL-Pantothenyl alcohol	Biochemical Assay Reagents	Others
DL-Panthenol (DL-Pantothenol) is an alcohol derivative of pantothenyl acid. DL-Panthenol exerts eyelash protection effect. DL-Panthenol is widely used in the Skin and hair conditioner research.

HY-N6072

Seco-neokadsuranic acid A

Others Others

Seco-neokadsuranic acid A is a triterpene acid isolated from Kadsura coccinea.
HY-W747583

Apocholic acid

Endogenous Metabolite Metabolic Disease

Apocholic acid, a Bile acid, is an endogenous metabolite.
HY-122207

Erythromycin A enol ether

Others Infection

Erythromycin A enol ether is an acidic degradation product of Erythromycin A (macrolide antibiotic) and has no antibacterial effect.
HY-W041076

3,5-Difluoro-DL-phenylalanine

Amino Acid Derivatives Others

3,5-Difluoro-DL-phenylalanine is a phenylalanine derivative that can be used for amino acids synthesis.
HY-77635

Z-D-Chg-OH

Amino Acid Derivatives Others

Z-D-Chg-OH is a glycine derivative that can be used for amino acid synthesis.
HY-W016424

H-β-HoIle-OH hydrochloride

Amino Acid Derivatives Others

H-β-HoIle-OH hydrochloride is an amino acid derivative that can be derived from synadenium grantii.
HY-W540122

Fmoc-PNA-C(Bhoc)-OH

Biochemical Assay Reagents Others

Fmoc-PNA-C(Bhoc)-OH is a peptide nucleic acid monomers, and can be used in the synthesis of peptide nucleic acid compounds.
HY-129847

Alitame anhydrous

Others Others

Alitame (anhydrous) is a high-intensity sweetener formed from the amino acids L-aspartic acid and D-alanine, and an amine derived from thietane.

Seco-neokadsuranic acid A	Others	Others
Seco-neokadsuranic acid A is a triterpene acid isolated from Kadsura coccinea.

Apocholic acid	Endogenous Metabolite	Metabolic Disease
Apocholic acid, a Bile acid, is an endogenous metabolite.

Erythromycin A enol ether	Others	Infection
Erythromycin A enol ether is an acidic degradation product of Erythromycin A (macrolide antibiotic) and has no antibacterial effect.

3,5-Difluoro-DL-phenylalanine	Amino Acid Derivatives	Others
3,5-Difluoro-DL-phenylalanine is a phenylalanine derivative that can be used for amino acids synthesis.

Z-D-Chg-OH	Amino Acid Derivatives	Others
Z-D-Chg-OH is a glycine derivative that can be used for amino acid synthesis.

H-β-HoIle-OH hydrochloride	Amino Acid Derivatives	Others
H-β-HoIle-OH hydrochloride is an amino acid derivative that can be derived from synadenium grantii.

Fmoc-PNA-C(Bhoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-C(Bhoc)-OH is a peptide nucleic acid monomers, and can be used in the synthesis of peptide nucleic acid compounds.

Alitame anhydrous	Others	Others
Alitame (anhydrous) is a high-intensity sweetener formed from the amino acids L-aspartic acid and D-alanine, and an amine derived from thietane.

HY-P2993

Isocitrate dehydrogenase ICDH	Isocitrate Dehydrogenase (IDH)	Metabolic Disease
Isocitrate dehydrogenase (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P)⁺ to NAD(P)H, it plays important roles in cellular metabolism.

HY-20897A

5-Bromo-L-tryptophan

Endogenous Metabolite Others

5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp..

HY-N7856

3-Oxooctadecanoic acid 3-Oxostearic acid	Others	Others
3-Oxooctadecanoic acid (3-Oxostearic acid) is a saturated fatty acid (SFA). 3-Oxooctadecanoic acid is an intermediate product in fatty acid biosynthesis and it was converted from malonic acid via the enzyme.

HY-N0593

Deoxycholic acid 5+ Cited Publications Cholanoic acid; Desoxycholic acid	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.

HY-N2855

Alphitolic acid 1 Publications Verification Aophitolic acid	Apoptosis Autophagy TNF Receptor Akt NF-κB	Cancer Inflammation/Immunology
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.

HY-N1652

2,3,8-Tri-O-methylellagic acid 3,3′,4-Tri-O-methylellagic acid	Others	Others
2,3,8-Tri-O-methylellagic acid is a terpenoids that can be isolated from the stem bark of Neoboutonia macrocalyx. 2,3,8-Tri-O-methylellagic acid is found to be 50 times more active than the parent ellagic acid.

HY-N0593A

Deoxycholic acid sodium salt 5+ Cited Publications Sodium deoxycholate	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.

HY-128700A

Nicotinic acid mononucleotide triethylamine 1 Publications Verification	Others	Metabolic Disease
Nicotinic acid mononucleotide triethylamine is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD⁺. Nicotinate mononucleotide triethylamine is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase.

HY-119647

PPOH	COX Cytochrome P450	Others
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC₅₀ values of 22 μM and 6.5 μM, respectively. PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0593B

Deoxycholic acid sodium hydrate Cholanoic acid sodium hydrate; Desoxycholic acid sodium hydrate	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1	Metabolic Disease
Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.

HY-P3150

Recombinant Proteinase K	Ser/Thr Protease	Others
Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations.

HY-109546

Omeprazole magnesium	Proton Pump	Metabolic Disease
Omeprazole magnesium is an orally active proton pump inhibitor (PPI) and can suppress gastric acid. Omeprazole magnesium can be used for acid reflux-related symptoms and frequent heartburn research.

HY-141540

Lactyl-CoA	Others	Others
Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers.

HY-N7813

1,2-Dipalmitoyl-3-oleoylglycerol	Others	Others
1,2-Dipalmitoyl-3-oleoylglycerol, a major P-containing triacylglycerol, can be found in palm oil, palm stearin, cocoa butter, and lard.

HY-N12350

Ellagic acid 3-O-α-L-rhamnopyranoside

Others Others

Ellagic acid 3-O-α-L-rhamnopyranoside is an ellagic acid derivative can be isolated from Folium Turpiniae.
HY-W127512

5β-Cholanic acid

Others Others

5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis.
HY-N3894

Ferulamide

nAChR Neurological Disease

Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. with anticholinesterase activities.

HY-N7880

Salvianolic acid Y	Reactive Oxygen Species	Cancer
Salvianolic acid Y is a phenolic acid with the same planar structure as Salvianolic acid B. Salvianolic acid Y rescues cell injury by H₂O₂.

HY-124087

(±)-2-Propyl-4-pentenoic acid 4-en-VPA; 2-Allylpentanoic acid	Drug Metabolite	Others
(±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity.

HY-W011711

Benzarone Fragivix	URAT1	Metabolic Disease
Benzarone (Fragivix) is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC₅₀ of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels.

HY-W145597

D-Glucuronamide

Others Others

D-Glucuronamide is the derivate of D-glucuronic acid.

HY-125847

Salvianolic acid F	Others	Cancer
Salvianolic acid F is a kind of Salvianolic Acids. Salvianolic Acids is the most effective and abundant compounds extracted from Salvia miltiorrhiza, with good anti-oxidative activity.

HY-14850

Sograzepide Netazepide; YF 476; YM-220	Cholecystokinin Receptor	Metabolic Disease Endocrinology
Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC₅₀ value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC₅₀ of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with K_i values of 0.068, 0.62 and 0.19 nM, respectively.

HY-136072A

(1R,2S)-Xeruborbactam disodium

(1R,2S)-QPX7728 disodium
Others Others

(1R,2S)-Xeruborbactam ((1R,2S)-QPX7728) disodium is a boronic acid derivative.

HY-150727

SIRT5 inhibitor 4	Sirtuin	Cancer
SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC₅₀ values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.

HY-W015424

N-Methyl-DL-glutamic acid

Endogenous Metabolite Others

N-Methyl-DL-glutamic acid is a L-Glutamic acid (HY-14608) analog with cytotoxic effects.

HY-Y1362

Ethyl pyruvate 5 Publications Verification	Others	Inflammation/Immunology
Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent.

HY-Y0507

DL-Serine 1 Publications Verification	TMV	Cancer Infection
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).

HY-147320

3'-DMTr-dG(dmf)

DNA/RNA Synthesis Others

3'-DMTr-dG(dmf) is a guanosine derivative used in the synthesis of nucleic acids.

HY-N11978

6-Hydroxykynurenic acid 6-HKA	iGluR	Neurological Disease
6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC₅₀: 59 μM).

HY-135298

Soya fatty acids

Others Metabolic Disease

Soya fatty acids is a class of polyunsaturated fatty acids extracted from soybean.

HY-N1800

3,3'-Di-O-methylellagic acid-4'-O-β-D-glucopyranoside	Others	Others
3,3'-Di-O-methylellagic acid-4'-O-β-D-glucopyranoside is a ellagic acid derivative that can be isolated from Dipentodon sinicus.

HY-118584

Ro 12-7310

Others Inflammation/Immunology

Ro 12-7310 is a synthetic retinoid, and can inhibit arachidonic acid release.

HY-B1427

Gamibetal Gamma-amino-beta-hydroxybutyric acid	Endogenous Metabolite	Neurological Disease
Gamibetal is the gamma-amino-beta-hydroxybutyric acid. Gamibetal has the potential for the research of epilepsy.

HY-W005963

Methyl 5-hydroxypyridine-2-carboxylate	Others	Inflammation/Immunology
Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune. Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro.

HY-W015410

Disodium succinate 3 Publications Verification	Endogenous Metabolite	Metabolic Disease
Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

HY-151715

N3-D-Dap(Fmoc)-OH	ADC Linker	Others
N3-D-Dap(Fmoc)-OH is a click chemistry reagent. N3-D-Dap(Fmoc)-OH can be used as a component for coupling by click reaction and as an orthogonally protected diaminocarboxylic acid derivative.

HY-W663527

Gly-Asp hydrate

Amino Acid Derivatives Others

Gly-Asp hydrate is a Glycine (HY-Y0966) derivative.
HY-D1457

DND-189

Fluorescent Dye Others

DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles.
HY-N3010

Salviaflaside

Others Inflammation/Immunology

Salviaflaside is a main bioactive component of Spica Prunellae.
HY-145673

Thiamphenicol glycinate

Others Others

Thiamphenicol glycinate, an alpha-amino acid ester, is a proagent of Thiamphenicol (HY-B0479).
HY-148217

DB02307

Others Others

DB02307 is a dipeptide that contains a sequence of two alpha-amino acids joined by a peptide bond.
HY-N1016

3β-Hydroxy-11,12-epoxy–friedoolean-14-enyl palmitate

Others Others

3β-Hydroxy-11,12-epoxy–friedoolean-14-enyl palmitate is a fatty acids esterified with triterpenes.

HY-76547

p-Toluic acid 1 Publications Verification 4-Methylbenzoic acid	Endogenous Metabolite	Others
p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.

HY-N12028

Acacetin 7-O-glucuronide	Others	Others
Acacetin 7-O-glucuronide is a glucuronide isolated from the methanolic leaf extract of Acacetin. Acacetin 7-O-glucuronide has potential applications in the development of nutraceuticals and pharmaceutical formulations.

HY-N10543A

3-p-Coumaroylquinic acid

Others Others

3-p-Coumaroylquinic acid (compound 3a) is an isomer of p-coumaroylquinic acid.
HY-N6217

F-14329

Endogenous Metabolite Others

F-14329 is a tetramic acid fungal metabolite.
HY-P3558

Ala-Ala-Ala-Tyr-Gly-Gly-Phe-Met

Amino Acid Derivatives Others

Ala-Ala-Ala-Tyr-Gly-Gly-Phe-Met
HY-150017

2'-O-Methyl-5-methyl-U CEP

Others Others

2'-O-Methyl-5-methyl-U CEP is a uridine, can be used for synthesis nucleic acid.

HY-W011819

Tetradecanedioic acid	Endogenous Metabolite	Metabolic Disease
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions .

HY-W013097

Boc-Arg(di-Z)-OH	Amino Acid Derivatives	Others
Boc-Arg(di-Z)-OH can be used for the synthesis of amino acid. Boc-Arg(di-Z)-OH can be used for the research of inhibitors for processing proteinases. Boc-Arg(di-Z)-OH is coupled via the mixed anhydride (MA) with HGlu(OBzl)-Lys(Z)-Arg(Z,Z)-CH2Cl.

HY-W003605A

1-Boc-DL-Pyroglutamic acid ethyl ester	Amino Acid Derivatives	Others
1-Boc-DL-Pyroglutamic acid ethyl ester is a Boc-protected Pyroglutamic acid derivative, can be used for the synthesis of agents or other compounds.

HY-41324

7-keto-Deoxycholic acid	Others	Others
7-keto-lithocholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-lithocholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition.

HY-I1124

L-Valine-d8 L-VALINE-2,3,4,4,4,5,5,5-d₈	Isotope-Labeled Compounds	Others
L-Valine-d₈ is a deuterated form of L-Valine. L-Valine-d₈ can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].

HY-134426

DL-β-Hydroxybutyryl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.

HY-D0115

7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester	DNA Stain	Others
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is a blue fluorescent dye for labeling proteins and nucleic acids.

HY-W016715

L-Cysteine hydrochloride hydrate 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans.

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective.

HY-N6613

Polygalacturonic acid Galacturonic acid polymer	Others	Infection Inflammation/Immunology
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.

HY-113074

Glycolithocholic acid 3-sulfate Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG	HIV Endogenous Metabolite	Infection Inflammation/Immunology
Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease.

HY-W127787

Tartaric acid sodium hydrate L-(+)-Tartaric acid sodium hydrate	Endogenous Metabolite	Others
L-Tartaric acid (L-(+)-Tartaric acid) sodium hydrate is the enantiomer of D-tartaric acid. L-Tartaric acid (HY-Y0293) is a white crystalline dicarboxylic acid found in many plants, such as grapes, and is one of the main organic acids in wine. L-Tartaric acid sodium hydrate which acts as a flour bulking agent and as a food additive can interact with sodium bicarbonate to produce carbon dioxide.

HY-126042

(±)-Lisofylline (±)-Lisophylline	Others	Metabolic Disease Inflammation/Immunology
(±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research.

HY-101108

Tazarotenic acid AGN 190299	Drug Metabolite	Others
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.

HY-117586

9-PAHPA	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
9-PAHPA is a fatty acid esters of hydroxy fatty acid (FAHFA). FAHFAs are a new family of endogenous lipids, have antidiabetic and anti-inflammatory effects.

HY-114360A

Taurohyodeoxycholic acid sodium	Interleukin Related TNF Receptor	Inflammation/Immunology
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-139285

Arachidonic acid-alkyne	Others	Metabolic Disease
Arachidonic acid-alkyne is aω‑alkynyl lipid surrogates for polyunsaturated fatty acid. Arachidonic acid-alkyne has low rates of oxidation. Arachidonic acid-alkyne can be used for tracking the polyunsaturated fatty acids.

HY-W048671

Fmoc-Thr(TBDMS)-OH	Amino Acid Derivatives	Others
Fmoc-Thr(TBDMS)-OH is a Threonine derivative. Fmoc-Thr(TBDMS)-OH can be used for the preparation of sugar ligand-tethered functional nucleic acid conjugates for targeted research.

HY-W042005

H-D-Phe(3,4-DiCl)-OH	Amino Acid Derivatives	Others
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity.

HY-W142161

Fmoc-N-Me-His(Trt)-OH Fmoc-MeHis(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-N-Me-His(Trt)-OH (Fmoc-MeHis(Trt)-OH) is a is an amino acid derivative containing amino and carboxyl groups. Fmoc-N-Me-His(Trt)-OH for the synthesis of Fmoc-MeHis (Trt) -Leu-OH.

HY-43470

3α,12β-Dihydroxycholanoic acid

Endogenous Metabolite Metabolic Disease

3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans.
HY-I1111S

Fmoc-L-Val-OH-d8

Isotope-Labeled Compounds Others

Fmoc-L-Val-OH-d₈ is a deuterium labeled Fmoc-L-Val-OH. Fmoc-L-Val-OH is a kind of protect amino acids[1].

HY-P4279

Ovalbumin (154-159)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Ovalbumin (154-159) is a fragment from ovalbumin. Ovalbumin (154-159) is a potent angiotensin-converting enzyme (ACE) inhibitor. Ovalbumin (154-159) can be used for research of hypertension.

HY-118146

Cicrotoic acid

Others Metabolic Disease

Cicrotoic acid is an unsaturated fatty acid that increases bile flow and changes lipid composition.

HY-149942

PAP-IN-1	Others	Others
PAP-IN-1 (compound 28) is an inhibitor of purple acid phosphatases (PAPs), a ubiquitous binuclear metallohydrolase. PAP-IN-1 inhibits mammalian PAP with K_i value of 168 nM. PAP-IN-1 targets to pig PAP with K_ic value of 0.17 μM. PAP inhibitors can be used for research of anti-osteoporotic drugs.

HY-147152

1-Myristoyl-3-chloropropanediol	Others	Others
1-Myristoyl-3-chloropropanediol is a 3-monochloropropanediol (3-MCPD) fatty acid ester. 3-MPCD causes nephropathy and tubular hyperplasia and adenomas by chronic oral administration; also reduces fertility, or provokes infertility in rats and suppresses the immune function.

HY-120996

10(E)-Pentadecenoic acid trans-10-Pentadecenoic acid	Others	Metabolic Disease
10(E)-Pentadecenoic Acid (trans-10-Pentadecenoic acid) is a long-chain monounsaturated fatty acid containing 15 carbons.

HY-N2012

7-Hydroxyaristolochic acid A	Others	Inflammation/Immunology
7-Hydroxyaristolochic acid A is an aristolochic acid analogue found in Aristolochia plants. Aristolochic acid can be used as an anti-inflammatory agent.

HY-149649

SARS-CoV-2-IN-64

SARS-CoV Infection

SARS-CoV-2-IN-64 (compound 9), a chenodeoxycholic acid derivative, is a potent inhibitor of spike glycoprotein of SARS-CoV-2.

HY-N7700A

Guluronic acid sodium 1 Publications Verification G2013 sodium	Endogenous Metabolite	Inflammation/Immunology
Guluronic acid sodium is an uronic acid monosaccharide and a glucuronic acid diasteroisomer. Guluronic acid sodium is a nonsteroidal anti-inflammatory agent.

HY-129982

SC-435	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
SC-435 is an apical sodium-dependent Bile acid (BA) transporter inhibitor. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations.

HY-125686

Beesioside Q

Others Others

Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr.

HY-143421

Curcumin monoglucuronide CMG	Drug Metabolite	Cancer
Curcumin monoglucuronide is known as a glucuronic acid conjugate, which is one of the in vivo metabolites of curcumin. Curcumin monoglucuronide is used for research on the metabolism of curcumin and examination of its development as a pharmaceutical. Curcumin monoglucuronide has the potential for the research of cancer disease (extracted from patent WO2022004873A1).

HY-111973

Phaseic acid	Others	Metabolic Disease
Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission.

HY-135801

Arachidonyl alcohol	Others	Metabolic Disease
Arachidonyl alcohol is a long-chain primary fatty alcohol. Arachidonyl alcohol is used as a substrate for the production of several ether lipids possessing beneficial functions.

HY-17623

Tegoprazan 2 Publications Verification CJ-12420; RQ-00000004	Proton Pump	Metabolic Disease
Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H⁺/K⁺-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H⁺/K⁺-ATPases in vitro.

HY-N12352

Eschweilenol C

Others Others

Eschweilenol C is a compound derivative ellagic acid from the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart..
HY-W297715

7-Acetoxy-4-bromomethylcoumarin

Fluorescent Dye Metabolic Disease

7-Acetoxy-4-bromomethylcoumarin acts as a fluorescence label for fatty acids.

HY-147382

Neuronotoxicity-IN-1	Others	Neurological Disease
Neuronotoxicity-IN-1, a pyridothiazine derivative, is a kainic acid neurotoxicity inhibitor. Neuronotoxicity-IN-1 is a neuroprotective agent.

HY-N1782

3,4-O-Isopropylidene-shikimic acid	Others	Inflammation/Immunology
3,4-O-Isopropylidene-shikimicn acid is a natural product that can be isolated from the whole plants of Hypericum wightianum. 3,4-O-Isopropylidene-shikimic acid has anti-inflammatory effect and antioxidant activities.

HY-115704

Butyryl-L-carnitine chloride

Others Others

Butyryl-L-carnitine chloride is an acylcarnitine that can be isolated from Plasma/Serum.

HY-149156

Lipid C24	Liposome	Cancer
Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids.

HY-133593

Palustric acid

Others Others

Palustric acid is a diterpenic resin acid found in Pinus nigra.

HY-P4524

FA-Phe-Phe	Angiotensin-converting Enzyme (ACE)	Others
FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A.

HY-P2834

Penicillin amidase Penicillin acylase	Biochemical Assay Reagents	Infection
Penicillin amidase (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics.

HY-N1558

Pterisolic acid A

Others Others

Pterisolic acid A can be isolated from the ethanol extract of the fern Pteris semipinnata (Pteridaceae).

HY-W243303E

Poly(acrylic acid) (MW 450000)	Biochemical Assay Reagents	Others
Poly(acrylic acid) (MW 450000) is a polyacrylic acid with a molecular weight of 450000. Poly(acrylic acid) (MW 450000) is an anionic polymer. Poly(acrylic acid) (MW 450000) can be as a corrosion-mitigating and surface-stabilizing agent.

HY-122338

Fexarine	FXR	Metabolic Disease
Fexarine is a potent, non-steroidal and selective agonist of farnesoid X receptor (EC₅₀: 38 nM). Fexarine can be used for the research of diseases linked to cholesterol, bile acids.

HY-106579S

Tiaprofenic acid-d3	COX	Inflammation/Immunology
Tiaprofenic acid-d₃ is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory agent (NSAID) mainly used in the treatment of rheumatic diseases[1].

HY-107395

BMS 753

RAR/RXR Inflammation/Immunology

BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a K_i of 2 nM.

HY-P3029

Phospholipase A2 PLA2	Phospholipase	Others
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies.

HY-149017

Apoptosis inducer 7	Apoptosis	Cancer
Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity.

HY-109105

Tepilamide fumarate XP-23829; PPC-06	Others	Inflammation/Immunology
Tepilamide fumarate (XP-23829; PPC-06) is an oral fumaric acid ester, acts as a proagent of Monomethyl fumarate (HY-103252), and is used in the research of moderate to severe chronic plaque psoriasis.

HY-N7606

(Rac)-β-Chamigrenic acid

Others Others

(Rac)-β-Chamigrenic acid is a racemate of β-Chamigrenic acid. β-Chamigrenic acid is a sesquiterpenoid isolated from S.chinensis

HY-N7240

(Rac)-Juvenile hormone III	Others	Endocrinology
(Rac)-Juvenile hormone III, a natural compound that can be isolated from farnesoic acid ,is the most widely distributed Juvenile hormone homologue.

HY-N1562

Pterisolic acid F

Others Others

Pterisolic acid F can be isolated from the ethanol extract of the fern Pteris semipinnata (Pteridaceae).

HY-113360

Chenodeoxycholic acid 3-sulfate	Endogenous Metabolite	Inflammation/Immunology
Chenodeoxycholic acid 3-sulfate is a bile acid. Chenodeoxycholic acid 3-sulfate level corresponds closely with the extent of hepatic dysfunction.

HY-129357

CCK-B Receptor Antagonist 2	Cholecystokinin Receptor	Metabolic Disease
CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC₅₀ value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC₅₀ of 1.82 μM.

HY-N8624

Ethyl 3,4-dicaffeoylquinate	Bacterial	Others
Ethyl 3,4-dicaffeoylquinate is a phenolic acid isolated from G. divaricata. G. divaricata is one of the famous traditional Chinese herbs, usually used for bronchitis, tuberculosis, twisted knot cough, rheumatism, diabetes, etc.

HY-117142

Quizalofop-P	Acetyl-CoA Carboxylase	Others
Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops.

HY-127035

Tristearin

Glycerol tristearate
Others Others

Tristearin is a triglyceride derived from three units of stearic acid.

HY-129467

(Rac)-Idroxioleic acid 2-Hydroxyoleic acid; 2-OHOA	Apoptosis	Cancer
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.

HY-113478

3β-Ursodeoxycholic acid Isoursodeoxycholic acid	Others	Metabolic Disease
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can be isomerized by intestinal and hepatic enzymes to yield UDCA.

HY-N8276

Ro 3-1314 9a,12a-Octadecadiynoic acid	Lipoxygenase	Metabolic Disease Inflammation/Immunology
Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments.

HY-15706

H2L 5765834

LPL Receptor Cardiovascular Disease

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA₁, LPA₃, and LPA₅, with IC₅₀s of 94, 752, and 463 nM respectively.

HY-135035

Decanoyl-L-carnitine (-)-Decanoylcarnitine	Others	Metabolic Disease
Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1-¹⁴C]-22:4 (n-6) and [1-¹⁴C]-22:5 (n-3).

HY-W004288

Methyl myristate	Others	Cancer
Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma.

HY-107830

Methyl cholate	Others	Metabolic Disease
Methyl Cholate is methyl ester form of Cholic acid. Cholic acid is one of the major bile acids produced by the liver, where it is synthesized from cholesterol.

HY-30216

(R)-Leucic acid

D-α-Hydroxyisocaproic acid
Endogenous Metabolite Others

(R)-Leucic acid is an amino acid metabolite.

HY-N1951

Miltirone	GABA Receptor	Neurological Disease
Miltirone is a natural compound present in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM.

HY-N10932

Lucidenic acid K

Others Others

Lucidenic acid K is a ganoderma acid isolated from strain G. lucidum fruiting body (YK-02).

HY-N0761A

trans-Isoferulic acid trans-3-Hydroxy-4-methoxycinnamic acid	NO Synthase Prostaglandin Receptor	Inflammation/Immunology
trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1).

HY-W142140

N-Methyl-DL-valine N-Methylvaline	Amino Acid Derivatives	Others
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability.

HY-139066

Punicic acid Trichosanic acid	Others	Metabolic Disease
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and a ω-5 polyunsaturated fatty acid. Punicic acid has the potential for the research of various chronic diseases.

HY-W011297

Methyl arachidonate Arachidonic acid methyl ester	Others	Metabolic Disease
Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.

HY-W072147

Fmoc-Ser-OMe Fmoc-L-Ser-OMe	Amino Acid Derivatives	Others
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor.

HY-105689

AGN 192870	RAR/RXR	Others
AGN 192870 is a RAR neutral antagonist with K_ds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism. AGN 192870 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1830

Vari Fluor 680 Carboxylic acid（free acid） VF 680 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 680 Carboxylic acid (VF 680 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-139078

Furosine dihydrochloride	Amino Acid Derivatives	Metabolic Disease
Furosine dihydrochloride, an amino acid derivative, is an important chemical marker of early-stage Maillard reactions. Furosine dihydrochloride is closely related to a variety of diseases such as diabetes.

HY-141576

C6-NBD Sphinganine

Fluorescent Dye Others

C6-NBD Sphinganine is a sphinganine analog and can be used as fluorescent dye for labeling fatty acid.

HY-121883

Lignoceric acid Tetracosanoic acid	Endogenous Metabolite	Neurological Disease
Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research.

HY-108455

N-Palmitoyl dopamine PALDA	Others	Neurological Disease
N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide.

HY-D0996

LDS-751	DNA Stain	Others
Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 has a high affinity for DNA and fluorescence is enhanced after binding, but the maximum emission wavelength is 670nm. Lds-751 and Thiazole orange can be used for the differentiation of red blood cells, platelets, reticulocytes, and nucleated cells and can be stimulated at 488nm. Studies have shown that LDS-751 binds almost exclusively to mitochondria when incubated with nucleated living cells. After nucleated Acridine Orange (HY-101879) staining and LDS-751 treatment of cells, confocal microscopy revealed almost no co-location of the cells. Staining with Rhodamine 123 (HY-D0816), a dye known to bind polarized mitochondria, was almost identical to the pattern observed with LDS-751.

HY-150125

SCD1-IN-1

Stearoyl-CoA Desaturase (SCD) Inflammation/Immunology

SCD1-IN-1 is a SCD1 inhibitor (IC₅₀: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-103355

YM022 1 Publications Verification	CCR	Metabolic Disease
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the K_i values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.

HY-D1825

Vari Fluor 532 Carboxylic acid（free acid） VF 532 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 532 Carboxylic acid (VF 532 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-113147B

L-Palmitoylcarnitine TFA 1 Publications Verification	Endogenous Metabolite Potassium Channel	Metabolic Disease Cardiovascular Disease
L-Palmitoylcarnitine TFA, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine TFA inhibits K_ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

HY-14739

Choline Fenofibrate ABT-335	PPAR COX	Cardiovascular Disease
Choline Fenofibrate (ABT-335), a choline salt of Fenofibric acid (HY-B0760), releases free Fenofibric acid in the gastrointestinal tract. Fenofibric acid is a PPAR activator with antihyperlipidemic effect.

HY-B1514

Allantoic acid

Endogenous Metabolite Others

Allantoic acid is a degradative product of uric acid and associated with purine metabolism.

HY-113437

1,2-Dipalmitoyl-sn-glycerol 3-phosphate	Endogenous Metabolite	Metabolic Disease
1,2-Dipalmitoyl-sn-glycerol 3-phosphate (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite.

HY-W008097

3,3-Dimethylglutaric acid	Endogenous Metabolite	Metabolic Disease
3,3-Dimethylglutaric acid, a member of methyl-branched fatty acids, is a endogenous metabolite occasionally found in human urine.

HY-14289A

Cimetidine hydrochloride SKF-92334 hydrochloride	Histamine Receptor Bacterial	Cancer Endocrinology
Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a K_i of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity.

HY-131591

Digalacturonic acid	Endogenous Metabolite	Others
Digalacturonic acid is a metabolite of pectin or pectic acid. Digalacturonic acid can be used for the co-crystallization of enzymes such as proteinase K.

HY-N11927

Manwuweizic acid

(+)-Manwuweizic acid
Others Others

Manwuweizic acid is a triterpenoid that can be isolated from Kadsura heteroclite.

HY-139040

2-(Tetradecylthio)acetic acid	PPAR	Metabolic Disease
2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator. 2-Tetradecylthio acetic acid induces hypolipidemia. 2-Tetradecylthio acetic acid reduces plasma lipids and enhances hepatic fatty acid oxidation in rodents. 2-Tetradecylthio acetic acid increases the expression of genes involved in fatty acid uptake, activation, accumulation, and oxidation.

HY-148702

di-Pal-MTO	Liposome	Cancer
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.

HY-150555

P-CAB agent 1	Potassium Channel	Others
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC₅₀ value of 60.50 nM for H⁺/K⁺-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs).

HY-P2947

ALDH Aldehyde dehydrogenase (NAD(P))	Aldehyde Dehydrogenase (ALDH)	Others
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress.

HY-131760

2'-NH2-ATP 2'-Amino-2'-deoxyadenosine-5'-triphosphate, 2′-Amino-2′-deoxy-ATP	Others	Metabolic Disease
2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate), an adenosine derivative, is a weak competitive inhibitor of ATP, with a K_i of 2.3 mM. 2'-NH2-ATP can be used in nucleic acid labeling.

HY-128473

Valeryl salicylate Valeroyl salicylate	COX	Inflammation/Immunology
Valeryl salicylate is a potent and irreversible cyclooxygenase-1 (COX-1) inhibitor. Valeryl salicylate shows anti-inflammatory effect.

HY-145952

(2E,9Z)-Octadeca-2,9-dienoic acid	Others	Metabolic Disease
(2E,9Z)-Octadeca-2,9-dienoic acid, a polyunsaturated fatty acid, can be used for the research of lipoxygenase-dependent metabolism.

HY-142105

2-Ethyl-2-hydroxybutanoic acid 2-Ethyl-2-hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease
2-Ethyl-2-hydroxybutanoic acid (2-Ethyl-2-hydroxybutyric acid) is a hydroxy fatty acid. 2-Ethyl-2-hydroxybutanoic is a metabolite of DEHP (HY-B1945).

HY-N10071

Poricoic acid G	Others	Cancer
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans.

HY-130803

5-Methyl-5,6-dihydrouridine	Others	Cancer
5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.

HY-113442

6-trans-12-epi-Leukotriene B4	Endogenous Metabolite Drug Metabolite	Inflammation/Immunology
6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.

HY-B0493

Niflumic acid 1 Publications Verification	Chloride Channel COX	Inflammation/Immunology
Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis.

HY-113017

Neuraminic acid	Endogenous Metabolite	Others
Neuraminic acid is an acidic amino sugar with a backbone formed by nine carbon atoms. Neuraminic acid may also be visualized as the product of an aldol-condensation of pyruvic acid and D-mannosamine (2-amino-2-deoxy-mannose). Neuraminic acid is a functional group of some biologically active mucoproteins.

HY-113437A

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite

HY-116246

5(S)-HETE lactone

Others Inflammation/Immunology

5(S)-HETE lactone is an arachidonic acid (AA) metabolite.

HY-101106

AR7 5 Publications Verification	RAR/RXR	Cancer Neurological Disease
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.

HY-147323

Ferulic acid 4-O-sulfate Ferulic acid 4-sulfate	Drug Metabolite	Cardiovascular Disease
Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) is a metabolite of Ferulic acid (HY-N0060). Ferulic acid 4-O-sulfate relaxes arteries and lowers blood pressure in mice.

HY-D0942

Acridine Orange zinc chloride salt Euchrysine 3RX	Parasite Fluorescent Dye DNA Stain	Others
Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm).

HY-N11416

Glycodehydrocholic acid	Endogenous Metabolite	Cancer Endocrinology Metabolic Disease
Glycodehydrocholic acid is a bile acid glycine conjugate. Glycodehydrocholic acid is used to diagnose cancer and other diseases.

HY-D0941

5-Carboxytetramethylrhodamine	Fluorescent Dye	Others
5-Carboxytetramethylrhodamine can be used as a fluorescent probe of nucleic acids and proteins. 5-Carboxytetramethylrhodamine displays excitation maxima of 558 nm and an emission maximum of 586 nm.

HY-147168

Biocytin hydrazide

Others Metabolic Disease

Biocytin hydrazide is a selective label for sialic acids, galactose, and other sugars in glycoconjugates using avidin-biotin technology.

HY-P2755

Xanthine oxidase	Reactive Oxygen Species	Endocrinology Inflammation/Immunology
Xanthine oxidase is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid.

HY-141570

Lyso-PAF C-16

Others Others

Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid.

HY-B0167S1

Salicylic acid-13C6 2-Hydroxybenzoic acid-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite Mitophagy COX Apoptosis Autophagy	Inflammation/Immunology Cancer
Salicylic acid-¹³C₆ is the ¹³C-labeled Salicylic acid (HY-B0167). Salicylic acid is a precursor to and a metabolite of Aspirin (HY-14654), can inhibit cyclo-oxygenase-2 (COX-2) activity[1][2].

HY-116100A

HA155

Phosphodiesterase (PDE) Inflammation/Immunology

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC₅₀ of 5.7 nM.

HY-155307

TGR5 agonist 4	G protein-coupled Bile Acid Receptor 1	Inflammation/Immunology
TGR5 agonist 4 (compound 19), a cholic acid derivative, is a selective TGR5 agonist with an EC₅₀ of 4 μM.

HY-135103

Tauro-β-muricholic acid sodium T-βMCA sodium	FXR	Cancer
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

HY-D1821

Vari Fluor 750 Carboxylic acid（free acid） VF 750 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 750 Carboxylic acid (VF 750 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-A0271

Aluminum Glycinate Dihydroxyaluminum Aminoacetate	Others	Inflammation/Immunology
Aluminum Glycinate, an organo-metallic compound, is an antacid. Aluminum Glycinate can be used for the research of indigestion, acid reflux and ulcers.

HY-D1828

Vari Fluor 640 Carboxylic acid（free acid） VF 640 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 640 Carboxylic acid (VF 640 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-D1829

Vari Fluor 568 Carboxylic acid（free acid） VF 568 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 568 Carboxylic acid (VF 568 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-W009082

Methyl behenate

Methyl docosanoate
Others Others

Methyl behenate (Methyl docosanoate) is a naturally fatty acid methyl ester isolated from the plant of Aspidopterys obcordata Lemsl.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-152033

URAT1 inhibitor 4	URAT1 GLUT	Metabolic Disease
URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC₅₀ of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258).

HY-101879

Acridine Orange hydrochloride 15+ Cited Publications	DNA Stain Parasite Fluorescent Dye	Others
Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm).

HY-P2416

Gastrin I, rat

Rat Gastrin-17
Cholecystokinin Receptor Endocrinology

Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently.

HY-D1826

Vari Fluor 594 Carboxylic acid（free acid） VF 594 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 594 Carboxylic acid (VF 594 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-112754A

DOTAP chloride 2 Publications Verification 1,2-Dioleoyl-3-trimethylammonium-propane chloride	Liposome	Cancer
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.

HY-W109613

Methyl dehydroabietate

Bacterial Infection

Methyl dehydroabietate is a kind of resin acid that can be isolated from spruce bark. Methyl dehydroabietate has antimicrobial activities.

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Others	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O.

HY-N2549A

(±)-trans-Abscisic acid (±)-trans-ABA	Others	Others
(±)-trans-Abscisic acid ((±)-trans-ABA) is an acid. (±)-trans-Abscisic acid can be isolated from strawberry tree (Arbutus unedo L.) honeys.

HY-B0172

Lithocholic acid 10+ Cited Publications 3α-Hydroxy-5β-cholanic acid	Autophagy Endogenous Metabolite Apoptosis FXR	Cancer Metabolic Disease
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist^{[1]^{^{[2]^{^{[3]^{^{[4]^{^{[5]^.}}}}}}}}}

HY-106200

CJ-13,610	Lipoxygenase	Inflammation/Immunology
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM. PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-27787

α-Eleostearic acid cis-Eleostearic acid	Apoptosis Ferroptosis	Cancer Metabolic Disease
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity.

HY-W010947

4-Methylumbelliferyl palmitate	Fluorescent Dye	Inflammation/Immunology
4-Methylumbelliferyl palmitate is an excellent fluorophore for measuring acid lipase in human leukocytes. Acidity and solvent have important influence on its fluorescence. 4-Methylumbelliferyl palmitate exists mainly as neutral molecular form which can be produced strong fluorescence at 445 nm in near neutral aqueous solutions, and exist mainly as anion form which can be produced stronger fluorescence at 445 nm in weak alkaline solutions.

HY-P3621

Biotinyl-Glucagon (1-29), human, bovine, porcine	GCGR	Metabolic Disease
Biotinyl-Glucagon (1-29), human, bovine, porcine is a biotinylated glucagon. Glucagon is a peptide hormone, produced by α-cells of the pancreas, can increase concentration of glucose and fatty acids in the bloodstream.

HY-N8588

Methyl ganoderate C6

Others Others

Methyl ganoderate C6 is a ganoderic acid. Methyl ganoderate C6 can be used for the research of various biochemical.

HY-W005178

Octadecanedioic acid	Endogenous Metabolite	Others
Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome.

HY-N7354

Quininic acid

Others Cardiovascular Disease

Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid.

HY-D1827

Vari Fluor 660 Carboxylic acid（free acid） VF 660 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 660 Carboxylic acid (VF 660 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-A0143

Dihomo-γ-linolenic acid 2 Publications Verification DGLA; all-cis-8,11,14-Eicosatrienoic acid	Endogenous Metabolite	Cancer Inflammation/Immunology Cardiovascular Disease
Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

HY-108398A

Mead acid 5,8,11-Eicosatrienoic acid	Others	Cancer Metabolic Disease
Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Others
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-N10433

Xanthine oxidase-IN-9 Icarisids E	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ of 31.81 μM.

HY-135500

ACT-373898	Endothelin Receptor	Endocrinology
ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist.

HY-113147A

L-Palmitoylcarnitine chloride 1 Publications Verification	Potassium Channel Endogenous Metabolite	Metabolic Disease Cardiovascular Disease
L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits K_ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

HY-D1578

C12FDGlcU	Fluorescent Dye	Others
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of β-glucuronidase (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm).

HY-D1823

Vari Fluor 647A Carboxylic acid（free acid） VF 647A Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 647A Carboxylic acid (VF 647A Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-W014141

5,6-O-Isopropylidene-L-ascorbic acid L-Ascorbic acid 5,6-acetonide	Biochemical Assay Reagents	Others
5,6-O-Isopropylidene-L-ascorbic acid (L-Ascorbic acid 5,6-acetonide) is an organic compound. 5,6-O-Isopropylidene-L-ascorbic acid is a derivative of L-Ascorbic acid (vitamin C). Ascorbic acid has antioxidant properties.

HY-N10044

3-Feruloyl-4-caffeoylquinic acid

Others Others

3-Feruloyl-4-caffeoylquinic acidis acaffeoyl, feruloyl quinic acidderivativeisolated fromroasted C.arabica.

HY-D1824

Vari Fluor 488 Carboxylic acid（free acid） VF 488 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 488 Carboxylic acid (VF 488 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-W048682

Fmoc-1-methyl-L-histidine

Amino Acid Derivatives Others

Fmoc-1-methyl-L-histidine is a Fmoc protected amino acid and can be used as an intermediate for peptide synthesis.

HY-D1822

Vari Fluor 555 Carboxylic acid（free acid） VF 555 Carboxylic acid（free acid）	Fluorescent Dye	Others
Vari Fluor 555 Carboxylic acid (VF 555 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use.

HY-108561

L-670596	Prostaglandin Receptor	Others
L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069.

HY-115899

Malonyl CoA	Endogenous Metabolite Mitochondrial Metabolism	Metabolic Disease
Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1.

HY-P4257

L-Isoleucyl-L-arginine	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues. L-Isoleucyl-L-arginine is a potent angiotensin-converting enzyme (ACE) inhibitor. L-Isoleucyl-L-arginine can be used for research of hypertension.

HY-131515

Tri-Salicylic acid	Others	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Tri-Salicylic acid is the compound with similar properties of salicylic acid. Tri-Salicylic acid has the potential for the research of inflammation, obesity and cardiovascular diseases (extracted from patent US20170368079A1, compound III).

HY-148701

mono-Pal-MTO	Liposome	Cancer
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.

HY-N8115

S-(4-Hydroxybenzyl)glutathione	Others	Neurological Disease
S-(4-Hydroxybenzyl)glutathione is a glutathione derivative. S-(4-Hydroxybenzyl)glutathione inhibits the in vitro binding of kainic acid to brain glutamate receptors, with an IC₅₀ of 2 μM.

HY-W004515

3-Pyridylacetic acid hydrochloride	Endogenous Metabolite	Others
3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids).

HY-78933

Fmoc-MMAE	Microtubule/Tubulin ADC Cytotoxin	Cancer
Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC.

HY-107233

Saponin CP4

Prosapogenin CP4
Others Others

Saponin CP4 is an oleanolic acid derivative which lacks a 23-OH. Saponin CP4 shows no growth inhibition.
HY-156050

Thioacetamide-S-oxide

Others Metabolic Disease

Thioacetamide-S-oxide, a Thiocetamide metabolite, is a δ-aminolevulinic acid (ALA) synthetase inhibitor.
HY-W015806

3-Pyridineacetic acid

Endogenous Metabolite Others

3-Pyridineacetic acid is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids).

HY-155306

TGR5 agonist 3	G protein-coupled Bile Acid Receptor 1	Inflammation/Immunology
TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC₅₀ of 5 μM.

HY-107343

Docosahexaenoic acid ethyl ester Ethyl docosahexaenoate	Others	Metabolic Disease Neurological Disease
Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects.

HY-W142073

7-Methyl-DL-tryptophan 7-Methyltryptophan	Amino Acid Derivatives	Infection
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof.

HY-100007

Vonoprazan 3 Publications Verification TAK-438 free base	Proton Pump Bacterial	Endocrinology
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H⁺,K⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori.

HY-100007A

Vonoprazan hydrochloride TAK-438 hydrochloride	Proton Pump Bacterial	Infection Endocrinology
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H⁺,K⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori.

HY-15295

Vonoprazan Fumarate 3 Publications Verification TAK-438	Proton Pump	Metabolic Disease
Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H⁺,K⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease.

HY-125954A

Uridine diphosphate glucuronic acid ammonium UDP-α-D-glucuronic acid ammonium	Endogenous Metabolite	Metabolic Disease
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum.

HY-128851B

Coenzyme A sodium	Endogenous Metabolite	Metabolic Disease
Coenzyme A sodium, a ubiquitous essential cofactor, is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids.

HY-N0729

Linoleic acid 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease Cardiovascular Disease Cancer
Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .

HY-128851

Coenzyme A	Others	Metabolic Disease
Coenzyme A, a ubiquitous essential cofactor, is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids.

HY-W102456

H-Phe(4-Ac)-OH L-4-Acetylphenylalanine	Others	Others
H-Phe(4-Ac)-OH is a keto-containing amino acid, which can be conversed from α-keto acids containing acetyl. H-Phe(4-Ac)-OH can be incorporated at the amber position to afford the mutant Z domain protein.

HY-128851A

Coenzyme A trilithium	Endogenous Metabolite	Metabolic Disease
Coenzyme A trilithium, a ubiquitous essential cofactor, is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids.

HY-137808

Succinyl-Coenzyme A sodium Succinyl-CoA sodium	Endogenous Metabolite	Metabolic Disease Neurological Disease
Succinyl-Coenzyme A (Succinyl-CoA) sodium is an intermediate of the citric acid cycle. Succinyl-Coenzyme A sodium can be converted to succinic acid and can also combines with glycine to form δ-ALA to synthesize porphyrins (heme). Succinyl-Coenzyme A sodium can be used in the study of metabolic, neurological and haematological abnormalities (such as porphyrias) caused by nutritional vitamin B₁₂ deficiency (resulting in a deficiency in Succinyl-Coenzyme A synthesis).

HY-W142092

N-Acetyl-DL-serine	Bacterial	Others
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands.

HY-146242

SN05	EAAT ASCT	Cancer
SN05 is a potent amino acid transport (AAT) inhibitor with K_is of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN05 can be used for researching anticancer.

HY-146241

SN40	EAAT ASCT	Cancer
SN40 is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer.

HY-D0869

CAPS N-Cyclohexyl-3-aminopropanesulfonic acid	Biochemical Assay Reagents	Others
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis.

HY-112169A

10-Formyltetrahydrofolic acid disodium	Endogenous Metabolite	Metabolic Disease
10-Formyltetrahydrofolic acid disodium is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid disodium can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines.

HY-117741

GSK951A

Others Others

GSK951A is a THPP analogue. GSK951A inhibits mycolic acid biosynthesis. GSK951A combines potency in culture with in vivo activity and lack of cytotoxicity.

HY-P1310

VKGILS-NH2	Protease Activated Receptor (PAR)	Inflammation/Immunology
VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells.

HY-W009362

DL-Isocitric acid trisodium salt 1 Publications Verification	Endogenous Metabolite	Others
DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is a substrate in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products, including fruit juices.

HY-143702

Fluorescent DOTAP

Liposome Cancer Inflammation/Immunology

Fluorescent DOTAP, a cationic lipid, can be used for the research of nucleic acid and protein delivery.

HY-110406A

(±)13-HpODE 13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide	Others	Others
(±)13-HpODE (13-hydroperoxylinoleic acid) is a racemic mixture of hydroperoxides, which is produced by the oxidation of linoleic acid by lipoxygenase.

HY-N10288

Eucalyptacid A	Fungal Endogenous Metabolite	Infection
Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM.

HY-105900

Ro 22-0654

Others Metabolic Disease

Ro 22-0654 is a potent lipid synthesis inhibitor. Ro 22-0654 inhibits hepatic fatty acid synthesis and has antiobesity effects.

HY-139557

Zastaprazan JP-1366	Proton Pump	Inflammation/Immunology
Zastaprazan (JP-1366) is a proton pump inhibitor (WO2018008929). Zastaprazan can be used for the research of gastrointestinal inflammatory diseases or gastric acid-related diseases.

HY-110138

PDP-EA

Others Others

PDP-EA is a compound that increases the amidohydrolase activity of FAAH (fatty acid amide hydrolase).

HY-146273

Xanthine oxidase-IN-7	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active XO (xanthine oxidase) inhibitor with an IC₅₀ of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout.

HY-134274

8-Br-GTP 8-Bromoguanosine-5'-triphosphate	Bacterial	Infection
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (K_i of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification.

HY-W098280

Phenylglycine methyl ester	Biochemical Assay Reagents	Others
Phenylglycine methyl ester is a chiral anisotropic reagent. Phenylglycine methyl ester can be used for absolute configuration determination of various chiral carboxylic acids.

HY-128749A

D-Glucaric acid tetrahydrate Calcium D-glucarate tetrahydrate	Endogenous Metabolite	Cancer
D-Glucaric acid tetrahydrate is the end-products of the D-glucuronic acid pathway in mammals. D-Glucaric acid tetrahydrate is also found in fruits and vegetables. D-Glucaric acid tetrahydrate can be used to reduce cholesterol and inhibits tumor development. D-Glucaric acid tetrahydrate also enhances human immunity and reduce cancer risks.

HY-N8592

4-O-Galloylquinic acid

Others Others

4-O-Galloylquinic acid is a quinic acid gallate that can be isolated from Quercus stenophylla.

HY-113130

Eicosadienoic acid 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.

HY-15453

Devimistat 5+ Cited Publications CPI-613	Apoptosis Mitochondrial Metabolism	Cancer
Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells.

HY-154804

DLin-M-C4-DMA

Liposome Others

DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids.

HY-W016784

Indole-3-acetamide 1 Publications Verification	Endogenous Metabolite	Others
Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid (HY-18569). Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class.

HY-B2145

Ilaprazole sodium IY-81149 sodium	Proton Pump TOPK	Cancer Inflammation/Immunology
Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H⁺/K⁺-ATPase in a dose-dependent manner with an IC₅₀ of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor.

HY-145437

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide

Fungal Infection

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent.
HY-121184

Epicoccamide

Endogenous Metabolite Others

Epicoccamide, a tetramic acid derivative, is secondary metabolite from Epicoccum purpurascens.

HY-101664

Ilaprazole IY-81149	Proton Pump TOPK	Cancer Inflammation/Immunology
Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H⁺/K⁺-ATPase in a dose-dependent manner with an IC₅₀ of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor.

HY-P4532

Ac-Leu-Val-Lys-Aldehyde	Cathepsin	Neurological Disease
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC₅₀s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II.

HY-N3592

Citreorosein

ω-Hydroxyemodin; NSC 624612
Others Others

Citreorosein is a natural product that can be isolated from Xanthoria parietina.
HY-124422

Pentacosanoic acid

Endogenous Metabolite Metabolic Disease

Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate.

HY-138646

Poly(deoxyadenylic-thymidylic) acid sodium	Biochemical Assay Reagents	Cancer Infection
Polydeoxyadenylic-thymidylic acid sodium is a synthetic DNA polymer. Polydeoxyadenylic-thymidylic acid sodium can be used to determine the activity of bound and free ribonucleic acid polymerase. Polydeoxyadenylic-thymidylic acid sodium can be used for the research of cancer and virus infection.

HY-146133

LA-Bac8c	Bacterial Antibiotic	Infection
LA-Bac8c is a Lipoic acid modified antimicrobial peptide with enhanced antimicrobial properties. LA-Bac8c inhibits S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa with MICs of 1, 4, 8, 8, and 8 μg/mL.

HY-N9457

Norcholic acid	Others	Endocrinology Metabolic Disease
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine.

HY-151778

Fmoc-Abg(N3)-OH	ADC Linker	Others
Fmoc-Abg(N3)-OH is a click chemistry reagent containing an azide group. Fmoc-Abg(N3)-OH has the potential to synthesize peptide nucleic acids (PNA) and peptoids.

HY-N11466

trans-Caffeoyl-6-O-D-gluconic acid	Others	Others
trans-Caffeoyl-6-O-D-gluconic acid is a natural product, that can be isolated from the nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth..

HY-12956B

(5R)-Dinoprost Prostaglandin F2β; PGF2β	Endogenous Metabolite	Others
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin.

HY-W018512

7-Ketolithocholic acid 3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite	Metabolic Disease
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.

HY-W127433

Isostearic acid

Others Others

Isostearic acid is a unique fatty acid. Isostearic acid is useful in pharmaceutical, personal care, and cosmetic products.

HY-N9933

Tauro-β-muricholic acid TβMCA	Apoptosis FXR	Cancer Metabolic Disease
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC₅₀ = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential.

HY-136896

FFA3 agonist 1	Free Fatty Acid Receptor	Metabolic Disease Inflammation/Immunology
FFA3 agonist 1 is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3.

HY-117145

Thiophene-2 TP2	Bacterial	Infection
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against *Mycobacterium tuberculosis* with a MIC value of 1 μM, and has potent anti-tuberculosis activity.

HY-Y1718

Tridecanoic acid N-Tridecanoic acid	Endogenous Metabolite Bacterial	Infection Metabolic Disease
Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation.

HY-145576B

2-Amino-8-oxononanoic acid hydrochloride	Others	Others
2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH.

HY-N7031

(±)-Vasicine (±)-Peganine	Proton Pump	Inflammation/Immunology
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H⁺-K⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect.

HY-W130610

Stearamide

Others Others

Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity.

HY-B1478

Dimaprit dihydrochloride	Histamine Receptor NO Synthase	Endocrinology
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC₅₀ of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion.

HY-126362

ML266	Glucosidase	Others
ML266 is glucocerebrosidase (GCase) molecule chaperone with IC₅₀ of 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.

HY-N4024

Hyptadienic acid	Others	Inflammation/Immunology
Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID₅₀ value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation.

HY-B0853

Paclobutrazol	Fungal	Infection
Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins. Paclobutrazol also has antifungal activities. Paclobutrazol, transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants. Paclobutrazol is typically used to support research on the role of gibberellins in plant biology.

HY-112169

10-Formyltetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines.

HY-126791A

Methylmalonyl coenzyme A tetralithium Methylmalonyl-CoA tetralithium	Endogenous Metabolite	Others
Methylmalonyl coenzyme A (Methylmalonyl-CoA) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl coenzyme A is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12.

HY-106559

Sorbinicate

Others Cardiovascular Disease

Sorbinicate, a derivative of nicotinic acid, exerts a favourable influence on blood rheology and platelet function.

HY-N7701E

L-Diguluronic acid disodium	Fungal	Infection
L-Diguluronic acid disodium is a linear polysaccharide copolymer composed of two L-guluronic acid. L-Diguluronic acid disodium can be used to form Alginate. L-Diguluronic acid disodium is a generic name of unbranched polyanionic polysaccharides and it can be used for the research of antifungal agents delivery carries.

HY-113972A

(E/Z)-Methyl mycophenolate	Others	Inflammation/Immunology
(E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.

HY-W010832

Uridine-5'-diphosphate disodium salt 1 Publications Verification	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52 for human P2Y₆ receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-N11173

cis-Melilotoside	Others	Metabolic Disease
cis-Melilotoside, an o-Coumaric acid derivative, shows potent antioxidant activity. cis-Melilotoside has antiprotozoal activity moderately against T. cruzi with an IC₅₀ of 78.2 ug/mL.

HY-W015495

L-Dihydroorotic acid

Endogenous Metabolite Others

L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.

HY-110407

2'-O,4'-C-Methyleneadenosine LNA-A	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.

HY-N2073

Ethyl linolenate	MCHR1 (GPR24)	Cardiovascular Disease
Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects.

HY-15387

Beclobrate

Sgd 24774
Others Cardiovascular Disease

Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents.

HY-B0172B

Isolithocholic acid 3β-Hydroxy-5β-cholanic acid; 3-Epilithocholic acid; β-Lithocholic acid	Endogenous Metabolite	Endocrinology
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.

HY-122504

Linoleoyl glycine	Potassium Channel	Neurological Disease
Linoleoyl glycine is a modified polyunsaturated fatty acid. Linoleoyl glycine has activating effects on human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in Xenopus oocytes.

HY-W011688

Methyl palmitoleate 1 Publications Verification (Z)-Methyl hexadec-9-enoate; Methyl cis-9-Hexadecenoate	Others	Others
Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.

HY-P2935

Glutamic acid protease

Endogenous Metabolite Others

Glutamic acid protease only can be found in fungi. Glutamic protease is a proteolytic enzyme containing a glutamic acid residue.

HY-W010820

Uridine 5'-diphosphate sodium salt	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-W269179

4-Bromomethyl-6,7-dimethoxycoumarin

Fluorescent Dye Cancer

4-Bromomethyl-6,7-dimethoxycoumarin is a fluorescent label for carboxylic acids in chromatographic detection.

HY-Y0444

D-Tyrosine	Tyrosinase	Metabolic Disease
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-W003445

4-Bromo-3-hydroxybenzoic acid	Endogenous Metabolite	Neurological Disease
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC₅₀s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC₅₀s of 1 mM for both enzymes.

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite	DNA/RNA Synthesis	Others
DMT-5Me-dC(Bz)-CE Phosphoramidite is used in the preparation of locked nucleic acids (LNAs) for optimization of fluorescent oligonucleotide probes with improved spectral properties and target binding.

HY-135795

1-Cyclohexyl-3-dodecyl urea CDU; N-Cyclohexyl-N-dodecyl urea; NCND	Epoxide Hydrolase	Metabolic Disease Cardiovascular Disease
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.

HY-N0455D

L-Arginine butanoate 5+ Cited Publications (S)-(+)-Arginine butanoate	Others	Others
L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations.

HY-125501

Biotin-XX hydrazide Biotin-(AC5)2-hydrazide	Biochemical Assay Reagents	Others
Biotin-XX hydrazide (Biotin-(AC5)2-hydrazide) is a carbonyl-reactive biotinylation reagent which contains two aminohexanoic acid spacers. Biotin-XX hydrazide has higher efficiency of avidin-binding.

HY-Y0469

1-Aminohydantoin hydrochloride	Drug Metabolite	Others
1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of AHD before detection.

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating Hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R.

HY-D1158

HKOCl-4m	Fluorescent Dye	Inflammation/Immunology
HKOCl-4m is a selective and mitochondria-targeting rhodol-based fluorescent probe for monitoring mitochondrial hypochlorous acid (HOCl).

HY-149272

tau/Aβ40 aggregation-IN-1	Tau Protein Amyloid-β Cholinesterase (ChE)	Neurological Disease
tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ₄₀ aggregation inhibitor with IC₅₀s of 1.8 μM and 1.3 μM, respectively.

HY-150204

ONO-0740556

LPL Receptor Inflammation/Immunology

ONO-0740556 is a potent Gi-coupled human lysophosphatidic acid receptor 1 (LPA1) agonist with an EC₅₀ value of 0.26 nM.

HY-145576

2-Amino-8-oxononanoic acid	Others	Others
2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH.

HY-12812

Autotaxin modulator 1	Phosphodiesterase (PDE)	Cancer Neurological Disease
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer.

HY-119735

Curcolone

Others Cardiovascular Disease

Curcolone is a sesquiterpenoid that inhibits collagen-induced or arachidonic acid (AA)-induced platelet aggregation.

HY-B1207

Urethane 2 Publications Verification Ethyl carbamate; Carbamic acid ethyl ester; Ethylurethane	Bacterial Parasite	Cancer Infection Neurological Disease
Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro.

HY-119596

Eupatoriochromene

Xanthine Oxidase Others

Eupatoriochromene is a chromene and has inhibitory activity against xanthine oxidase (XO).

HY-N6599

3-Feruloylquinic acid 3-O-Feruloylquinic acid	Others	Others
3-Feruloylquinic acid, a derivative of quinic acid-bound phenolic acid, shows antioxidant activity. 3-Feruloylquinic acid markedly enhances by high photosynthetically active radiation (PAR) and UV irradiances.

HY-114669

Polyoxin C

Others Others

Polyoxin C, the hybrid compound of nucleosides and R-amino acids, is important as the C-terminal amino acid component of Nikkomycin.

HY-N3048

Piperlotine D	Others	Cardiovascular Disease
Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC₅₀ of 43.4 μg/mL.

HY-157026

Nurr1 agonist 7

Others Cancer

Nurr1 agonist 7 (compound 110) is a Nurr1 agonist with an EC₅₀ value of 0.12 μM.

HY-W001959

D-Allothreonine	Endogenous Metabolite	Metabolic Disease
D-Allothreonine is the D type stereoisomer of Allothreonine. D-Allothreonine is a peptido-lipid derived from bacteria. D-Allothreonine, amide-linked to the D-galacturonic acid, is also a constituent in the polysaccharide.

HY-124962

D-NMAPPD (1R,2R)-B13	iGluR	Cancer Neurological Disease
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs.

HY-W270810

Nurr1 agonist 8

Others Others

Nurr1 agonist 8 (compound 111) is a Nurr1 agonist with an EC₅₀ value of 0.09 μM.

HY-N0667S7

L-Asparagine-13C4,15N2 (-)-Asparagine-13C4,15N2; Asn-13C4,15N2; Asparamide-13C4,15N2	Isotope-Labeled Compounds	Others
L-Asparagine-13C4,15N2 ((-)-Asparagine-13C4,15N2) is the 13C and 15N-labeled L-Aspartic acid. L-Aspartic acid is an amino acid, shown to be a suitable pro-agent for colon-specific drug delivery.

HY-W009749C

L-Cystathionine dihydrochloride	Apoptosis Endogenous Metabolite	Cardiovascular Disease
L-Cystathionine (dihydrochloride) is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine (dihydrochloride) protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine (dihydrochloride) plays an important role in cardiovascular protection.

HY-B0873

Uniconazole	Cytochrome P450 ROS Kinase	Others
Uniconazole, a plant growth retardant, is a potent inhibitor of abscisic acid (ABA) catabolism with an IC₅₀ of 68 nM against ABA 8’-hydroxylase. Uniconazole is a potent competitive inhibitor of CYP707A3 activity with a K_i of 8 nM. Uniconazole evidently inhibits gibberellin biosynthesis, and brassinosteroid biosynthesis is also inhibited to some extent.

HY-A0261

Pentagastrin 1 Publications Verification ICI-50123	Cholecystokinin Receptor	Cancer Endocrinology
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCK_B) receptor antagonists with IC₅₀ values of 11 nM and 1100 nM for CCK_B and CCK_A, respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..

HY-N1891

4'-Demethyl-3,9-dihydroeucomin

Others Others

4'-Demethyl-3,9-dihydroeucomin (Compound 3) is a high isoflavonoid derived from the agave Ledebouria floribund.

HY-N6998

Paederosidic acid	Apoptosis	Cancer
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.

HY-A0261A

Pentagastrin meglumine ICI-50123 meglumine	Cholecystokinin Receptor	Cancer Endocrinology
Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCK_B) receptor antagonists with IC₅₀ values of 11 nM and 1100 nM for CCK_B and CCK_A, respectively. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..

HY-N0200

Albaspidin AP	Fatty Acid Synthase (FASN)	Cancer Metabolic Disease
Albaspidin AP inhibits fatty acid synthase (FAS) with an IC₅₀ value of 71.7 μM. Fatty acid synthase (FAS) is emerging as a potential therapeutic target for cancer and obesity.

HY-P1310A

VKGILS-NH2 TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
VKGILS-NH2 TFA is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 TFA has no effect on DNA synthesis in cells.

HY-14781

Levomefolic acid 1 Publications Verification 5-MTHF	Endogenous Metabolite Reactive Oxygen Species DNA/RNA Synthesis	Cancer Infection
Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements.

HY-145122

ELOVL1-IN-1	Others	Metabolic Disease
ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD).

HY-130025

HKOCl-3

Fluorescent Dye Others

HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.E_x: 490 nm; E_m 527 nm.

HY-139427

3-Methylglutaconic acid β-Methylglutaconic acid	GABA Receptor	Metabolic Disease Neurological Disease Cardiovascular Disease
3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research.

HY-W009362S

DL-Isocitric acid-13C4 trisodium salt	Isotope-Labeled Compounds	Others
DL-Isocitric acid-¹³C₄ (trisodium salt) is a ¹³C labeled DL-Isocitric acid (trisodium salt) (HY-W009362). DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is a substrate in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products, including fruit juices.

HY-D0150

Thiazole Orange 1 Publications Verification	Fluorescent Dye	Others
Thiazole orange is an unsymmetrical cyanine dye which can be conjugated to oligonucleotides (ONs) to create fluorogenic hybridisation probes. Thiazole orange can be used for reticulocyte analysis.

HY-100807S2

Quinolinic acid-13C4,15N	Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist and has the potential of mediating NMDA neuronal damage and dysfunction.

HY-143473

FabG1-IN-1

Bacterial Infection

FabG1-IN-1 (Compound 29) is a potent MabA (FabG1) inhibitor with an IC₅₀ of 38 µM.

HY-130419

(±)13(14)-EpDPA 13,14-EpDPE	Others	Neurological Disease Cardiovascular Disease
(±)13(14)-EpDPA (13,14-EpDPE) is the product of the reaction of cytochrome P-450 epoxygenase with Docosahexaenoic Acid (DHA).(±)13(14)-EpDPA has antihyperalgesic and vasorelaxative activities.

HY-149898

HA-CD44 interaction inhibitor 1	Others	Cancer
Antitumor agent-109 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44, as well as an anti-tumor agent. Hyaluronic acid interacts with differentiation cluster 44 (CD44) and is involved in tumor growth and invasion. Antitumor agent-109 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM.

HY-B1475

Anisotropine bromide Octatropine bromide	mAChR	Metabolic Disease Neurological Disease
Anisotropine (Octatropine) bromide is an orally active anticholinergic muscarinic antagonist. Anisotropine bromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers.

HY-100413

CS-526	Proton Pump	Inflammation/Immunology
CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H⁺,K⁺-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease.

HY-D1319

Cyanine5 carboxylic acid chloride Cy5 acid chloride	Fluorescent Dye	Others
Cyanine5 carboxylic acid chloride (Cy5 acid chloride) is a fluorescent dye containing a non-activated carboxylic acid (Ex=646 nm, Em=662 nm). Cyanine5 carboxylic acid chloride is an non-reactive dye that can be used in control samples.

HY-D1079

EDANS sodium	DNA Stain	Others
EDANS sodium is a potent fluorogenic substrates. EDANS sodium is a donor for FRET-based nucleic acid probes and protease substrates. EDANS sodium is often paired with DABCYL or DABSYL. The optimal absorbance and emission wavelengths of EDANS sodium are λ_abs = 336 nm and λ_em = 490 nm respectively.

HY-111975

7'-Hydroxy ABA 7'-OH ABA	Others	Metabolic Disease
7'-Hydroxy ABA (7'-OH ABA) is a metabolite of Abscisic acid (Abscisic acid) through hydroxylation of the 7′-carbon atom of Abscisic acid. 7'-Hydroxy ABA exhibits significant hormonal activity.

HY-W008833

3-Aminobutanoic acid	Bacterial	Infection
3-Aminobutanoic acid is a β-amino acid. 3-Aminobutanoic acid can protect plant against a challenge infection with P. infestans. 3-Aminobutanoic acid has various levels of susceptibility for the pathogen.

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.

HY-B1274

Cinromide 2 Publications Verification trans-3-Bromo-N-ethylcinnamamide	Others	Metabolic Disease Neurological Disease
Cinromide is an anticonvulsant agent. Cinromide inhibits epithelial neutral amino acid transporter B⁰AT1 (SLC6A19) with an IC₅₀ of 0.5 μM.

HY-16007

(-)-Hydroxycitric acid Garcinia acid	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss.

HY-P2921

Urate oxidase Uox	Endogenous Metabolite	Others
Urate oxidase (Uox), i.e., uricase, is often used in biochemical studies. Urate oxidase is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals.

HY-115900

Tuberculosis inhibitor 4	Bacterial	Infection
Tuberculosis inhibitor 4 (compound 16), a mandelic acid-based spirothiazolidinone, has potent antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv with the high inhibition value 98% at lower than 6.25 µg/mL concentration.

HY-124527

HET0016 2 Publications Verification	Cytochrome P450	Cardiovascular Disease
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC₅₀ values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth.

HY-N3221

Myriceric acid C

Others Others

Myriceric acid C, a saturated fatty acid, is a natural product that can be isolated from Myrica cerifera.

HY-N12267

N,N′-Diferuloylputrescine	Melanocortin Receptor	Metabolic Disease
N,N′-Diferuloylputrescine is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species.

HY-B1789A

Telenzepine dihydrochloride	mAChR	Neurological Disease
Telenzepine dihydrochloride is a selective and orally active muscarinic M1 receptor antagonist with a K_i of 0.94 nM. Telenzepine dihydrochloride inhibits gastric acid secretion and has antiulcer effects.

HY-120139

KMH-233	Others	Cancer
KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM).

HY-116141

7-Hydroxycoumarinyl arachidonate 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate	Phospholipase MAGL	Others
7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer.

HY-151656

15-Azido-pentadecanoic acid Azido Palmitic acid	ADC Linker	Others
15-Azido-pentadecanoic acid is a click chemistry reagent containing an azide group. Azido Palmitic Acid can be used to identify and characterize post-translationally palmitylated proteins with using a simple and robust two-step labeling and detection technique. 15-Azido-pentadecanoic acid is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-B0033

Vigabatrin hydrochloride 5+ Cited Publications γ-Vinyl-GABA hydrochloride	GABA Receptor	Neurological Disease
Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

HY-19886

F 16915	Others	Cardiovascular Disease
F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation.

HY-151751

BDP TMR alkyne	Fluorescent Dye	Others
BDP TMR alkyne is an alkyne-containing click chemistry reagent that can click chemistry with azides. BDP TMR alkyne has the fluorophore BDP and can be used for oligonucleotide labeling and amino acid sequencing.

HY-B0399

L-Carnitine 5+ Cited Publications (R)-Carnitine; Levocarnitine	Endogenous Metabolite	Neurological Disease Cancer
L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-133596

12,14-Dichlorodehydroabietic acid	Potassium Channel GABA Receptor	Neurological Disease
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca²⁺-activated K⁺ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABA_A antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca²⁺ and stimulates transmitter release.

HY-N2581

Phytic acid sodium salt myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt	Endogenous Metabolite	Others
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant.

HY-138616

dGTP 2'-Deoxyguanosine-5'-triphosphate	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Cancer Infection
dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-D1617

BODIPY 500/510 C1, C12	Fluorescent Dye	Others
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells. Maximum excitation/emission wavelength: 500/510 nm. Protect from light, stored at -20℃.

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica.

HY-19996

AH-7614	Free Fatty Acid Receptor	Metabolic Disease
AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC₅₀s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC₅₀<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist.

HY-D1124

Mordant brown 1	Fluorescent Dye	Others
Mordant brown 1, a naphthalenesulphonic acid derivative, is an azo dye. Mordant brown 1 is also an effective and specific inhibitor of CD40-CD154 costimulatory protein-protein interaction.

HY-137868

Decanoyl coenzyme A

Decanoyl CoA
Endogenous Metabolite Endocrinology

Decanoyl coenzyme A (Decanoyl CoA) is a primer for the fatty acid elongation system in Mycobacterium smegmat.

HY-141700

FATP1-IN-2 2 Publications Verification	FATP	Metabolic Disease
FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC₅₀=0.43 μM, mouse IC₅₀=0.39 μM).

HY-B1132

Clidinium bromide Ro 2-3773	mAChR	Neurological Disease
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.

HY-129503

2-Heptyl-4-quinolone	Others	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA).

HY-101016

17-ODYA	Cytochrome P450 Apoptosis	Cardiovascular Disease
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC₅₀<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N10590

Arborescosidic acid Deacetylalpinoside	Others	Others
Arborescosidic acid (Deacetylalpinoside) is a carboxylated iridoid glucoside, that can be isolated from Veronica beccabunga (brooklime).

HY-148377

Abiraterone sulfate N-oxide	Others	Cancer
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer.

HY-W017443

L-Asparagine monohydrate 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N6877

Purpurogallin carboxylic acid	Others	Cancer
Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity.

HY-149037

GL67 N4-Spermine cholesteryl carbamate	Liposome	Others
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection.

HY-124301

Penicolinate A	Bacterial	Infection
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities.

HY-D0220

Toluidine Blue Toluidine Blue O	Fluorescent Dye	Cancer
Toluidine Blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain.

HY-138540

1-Dodecylimidazole N-Dodecylimidazole	Fungal	Cancer
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.

HY-145225

DLin-K-C3-DMA

Liposome Others

DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid.

HY-156358

AChE-IN-43	Cholinesterase (ChE)	Neurological Disease
AChE-IN-43 is a potent and selective inhibitor of AChE with a K_i of 0.41 μM. AChE-IN-43 can be used in study neurological disease.

HY-113884B

(S)-Coriolic acid 13(S)-HODE	PPAR Mitochondrial Metabolism	Cancer Inflammation/Immunology
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.

HY-133068

5-Hydroxyferulic acid	COMT Endogenous Metabolite	Others
5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate.

HY-W010629

2-Chloroacetamide	Bacterial	Infection
2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase.

HY-15399

Vigabatrin 5+ Cited Publications γ-Vinyl-GABA	GABA Receptor	Neurological Disease
Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

HY-109079A

Abeprazan hydrochloride DWP14012 hydrochloride; Fexuprazan hydrochloride	Proton Pump	Metabolic Disease
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H⁺, K⁺- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.

HY-B0946

Sulfamonomethoxine	Bacterial Antibiotic	Infection
Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

HY-W010062

4-Chlorophenylacetic acid	Others	Cancer Metabolic Disease
4-Chlorophenylacetic acid is a compound belongs to a family of small aromatic fatty acids with anticancer properties. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp.

HY-116374S

Glycolithocholic acid-d4 Lithocholylglycine-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

HY-W009993

3,4-Methylenedioxycinnamic acid	Others	Others
3,4-Methylenedioxycinnamic acid is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. 3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid.

HY-76199

trans-4-Hydroxycyclohexanecarboxylic acid	Others	Metabolic Disease
trans-4-Hydroxycyclohexanecarboxylic acid is a substrate for cyclohexanecarboxylic acid production. trans-4-Hydroxycyclohexanecarboxylic acid is the by-product of intestinal bacterial metabolism via urinary excretion.

HY-P2974

Elastase from porcine pancreas EC 3.2.1.35	Elastase	Metabolic Disease
Elastase from porcine pancreas is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters.

HY-P1202A

CYN 154806 TFA 1 Publications Verification	Somatostatin Receptor	Endocrinology
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC₅₀ values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride	Liposome	Others
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection.

HY-132145

5-Propargylamino-ddUTP	DNA/RNA Synthesis	Others
5-Propargylamino-ddUTP, a nucleoside molecule that can be used to synthesis of cyanine dye-nucleotide conjugate which is used in nucleic acid labeling or sequence analysis.

HY-N3265

Methyl sinapate

MSA
Others Others

Methyl sinapate (MSA), a hydroxycinnamic acid, is a natural UV screening agent.

HY-N8522

9,10-Dihydroxystearic acid	Others	Metabolic Disease
9,10-Dihydroxystearic acid is an oxidation product of oleic acid. 9,10-Dihydroxystearic acid can improve glucose tolerance and insulin sensitivity in KKAy mice.

HY-132142

5-Propargylamino-dCTP	DNA/RNA Synthesis	Others
5-Propargylamino-dCTP is a nucleoside molecule extracted from patent US9035035B2, compound dCTP-PA. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis. 5-Propargylamino-dCTP is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W440815

6-((4-Hydroxybutyl)amino)hexyl 2-hexyldecanoate	Others	Others
6-((4-Hydroxybutyl)amino)hexyl 2-hexyldecanoate is a lipid, it can be used to synthesis nanomaterials. 6-((4-Hydroxybutyl)amino)hexyl provides the use of the nano-lipid particle as the key component in nucleic acid delivery, including the components of the delivery carrier.

HY-D0785

NBD-F 4-Fluoro-7-nitrobenzofurazan	Fluorescent Dye	Others
NBD-F (4-Fluoro-7-nitrobenzofurazan) is a pro-fluorescent reagent which is developed for amino acid analysis. NBD-F reacts with primary or secondary amines to produce a fluorescent product and used for analysis of amino acids and low molecular weight amines.

HY-17421

Tenatoprazole TU-199	Proton Pump	Infection Inflammation/Immunology
Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H⁺/K⁺-ATPase activity with an IC₅₀ of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV.

HY-16100

BI 99179 1 Publications Verification	Fatty Acid Synthase (FASN)	Cancer Metabolic Disease
BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC₅₀ of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats.

HY-134564

Fluorescein octadecyl ester	Fluorescent Dye	Others
Fluorescein octadecyl ester is a lipophilic fluorescent reagent is immobilized in a plasticized PVC membrane. Fluorescein octadecyl ester can reversibly recognize alcohol molecules and can be used to determine the concentration of ethanol in alcoholic drinks. Fluorescein octadecyl ester can be used as acceptor to make optrode membrane for the determination of picric acid.

HY-113330

12S-HHT 12(S)-HHTrE	Leukotriene Receptor Endogenous Metabolite	Inflammation/Immunology
12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H₂ (PGH₂) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.

HY-128476

Sodium Tartrate	Others	Others
Sodium Tartrate is a pH-Regulating agent with antioxidant activity. Sodium Tartrate is particularly effective retarding hydrolysis while heating at high temperatures, resulting in increase of acid values (AVs) of vegetable oils.

HY-106084

Cefteram T-2525; RO 19-5247; Cefterame	Bacterial	Infection
Cefteram (T-2525) is the free acid of Cefteram pivoxil (HY-106571), which is an orally active cephalosporin ester. Cefteram potently targets to the enteropathogenic Enterobacteriaceae and Vibrionaceae.

HY-147004

A-908292	Acetyl-CoA Carboxylase	Metabolic Disease
A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism. A-908292 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0172S

Lithocholic acid-d4 3α-Hydroxy-5β-cholanic acid-d₄	Autophagy Apoptosis	Metabolic Disease
Lithocholic acid-d₄ is the deuterium labeled Lithocholic acid, which is a toxic secondary bile acid[1].

HY-Y0695

Amido Black 10B Naphthol Blue Black	Fluorescent Dye	Others
Amido Black 10B (Naphthol Blue Black) is a highly toxic azo dye for amino acid staining. Amido Black 10B can create several problems in the human respiratory system and may also cause skin and eye irritations.

HY-W015343

3-Methoxyphenylacetic acid m-Methoxyphenylacetic acid	Endogenous Metabolite	Others
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot.

HY-132146

5-Propargylamino-ddCTP	DNA/RNA Synthesis	Others
5-Propargylamino-ddCTP, a nucleoside molecule that can be used to synthesis of cyanine dye-nucleotide conjugate which is used in nucleic acid labeling or sequence analysis.

HY-D1296

Green DND-26	Fluorescent Dye	Others
Green DND-26 is a green fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 504/511 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and generally gather on spherical organelles. Green DND-26 is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes.

HY-W441002

DSPE-succinic acid	Liposome	Others
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics.

HY-120139A

(R)-KMH-233	Others	Cancer
(R)-KMH-233 is the inactive isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM).

HY-N12305

4,5-O-Dicaffeoyl quinic acid methyl ester	RSV	Infection
4,5-O-Dicaffeoyl quinic acid methyl ester (compound 4), a dicaffeoylquinic acid, has potent antiviral activity against respiratory syncytial virus (RSV) with an IC₅₀ of 0.63 μg/mL and a CC₅₀ of 118.68 μg/mL.

HY-W014502

D-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cancer
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Cancer Inflammation/Immunology
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.

HY-131670

(±)9,10-DiHOME	Others	Inflammation/Immunology
(±)9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages.

HY-N1524

Quinovic acid

Others Others

Quinovic acid is a natural product that can be isolated from Zygophyllum fabago L.

HY-N11638

Ganoderic acid R	Apoptosis	Cancer
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing apoptosis on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1).

HY-123863

SSR411298	FAAH	Neurological Disease
SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research.

HY-B0946S

Sulfamonomethoxine-d4	Bacterial	Infection
Sulfamonomethoxine-d₄ is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate[1].

HY-147321

3'-DMTr-dG(iBu)	Tau Protein HBV	Infection Neurological Disease
3'-DMTr-dG(iBu) is a nucleoside for the synthesis of nucleic acid, such as antiviral agents used in the research of viral infection (HBV, HDV), and oligonucleotides against Alzheimer’s disease and other tauopathies.

HY-148323

Anti-Trypanosoma cruzi agent-4	Parasite	Infection
Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection.

HY-P4029

HCV-1 e2 Protein (484-499)	HCV	Infection
HCV-1 e2 Protein (484-499) is a peptide consisting of 16 amino acids. HCV-1 e2 Protein (484-499) is derived from the envelope 2 protein of hepatitis C virus in the sera from individuals with antibodies to HCV.

HY-113443

12(S)-HPETE	Others	Metabolic Disease
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

HY-13100

PF 03716556	Proton Pump	Metabolic Disease
PF 03716556 is a potent, selective, competitive and reversible acid pump (H⁺,K⁺-ATPase) antagonist with pIC₅₀s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H⁺,K⁺-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research.

HY-P1202

CYN 154806 1 Publications Verification	Somatostatin Receptor	Endocrinology
CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC₅₀ values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

HY-113305

Dopamine 3-O-sulfate	Endogenous Metabolite	Metabolic Disease
Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency.

HY-120019A

Ac-YVAD-CHO acetate L-709049 acetate	Interleukin Related Caspase Apoptosis	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ.

HY-N1272

Secaubryenol	Endogenous Metabolite	Others
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 µg/mL.

HY-15682G

TTNPB Ro 13-7410; Arotinoid acid; AGN191183	RAR/RXR	Cancer
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist.

HY-135652

Hexyl gallate Hexyl 3,4,5-trihydroxybenzoate	Bacterial Parasite	Infection
Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR. Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC₅₀ of 0.11 mM.

HY-153972

URAT1&XO inhibitor 2	Xanthine Oxidase URAT1	Metabolic Disease Inflammation/Immunology
URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC₅₀ of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a K_i value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia.

HY-N0216S

Benzoic acid-d5	Bacterial Fungal Endogenous Metabolite	Infection
Benzoic acid-d₅ is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi[1][2].

HY-N2078

Yamogenin Neodiosgenin	LXR	Metabolic Disease
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes.

HY-W127715

Lucifer Yellow CH dipotassium salt 1 Publications Verification	Fluorescent Dye	Others
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively.

HY-109079

Abeprazan DWP14012; Fexuprazan	Proton Pump	Metabolic Disease
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H⁺, K⁺- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.

HY-D1738

DAPI dilactate 4',6-Diamidino-2-phenylindole dilactate	Fluorescent Dye
DAPI (dilactate) is a blue fluorescent dye that preferentially binds dsDNA and binds to minor groove AT clusters. DAPI (dilactate) is combined with dsDNA, and the fluorescence was enhanced about 20-fold. DAPI (dilactate) can be used to identify the cell cycle and specifically stains the nucleus but not the cytoplasm. DAPI (dilactate) form is more soluble in water than DAPI (dihydrochloride) form.

HY-P5077

Guanylin (mouse, rat)	Guanylate Cyclase	Metabolic Disease
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea.

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively.

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ.

HY-151617

sEH inhibitor-11	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-11 (compound 35) is a sEH inhibitor with an IC₅₀ value of 0.3 μM. sEH inhibitor-11 can be used for the research of inflammation.

HY-123070

ONO-RS-082	Phospholipase	Inflammation/Immunology
ONO-RS-082 is an inhibitor of phospholipase A (PLA). ONO-RS-082 inhibits PLA2 with the IC₅₀ of 1.0 μM, but does not inhibit PLC even at 100 μM.

HY-D1491A

Fast Red Violet LB Zinc chloride	Fluorescent Dye	Others
Fast Red Violet LB Zinc chloride is a dye for staining tartrate resistant acid phosphatase (TRAP). Fast Red Violet LB Zinc chloride can be used for alkaline phosphatase (ALP) activity staining.

HY-13662

Lansoprazole 1 Publications Verification AG-1749	Proton Pump Bacterial Phospholipase	Inflammation/Immunology Cancer
Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).

HY-110288

3FAx-Neu5Ac	Others	Metabolic Disease
3FAx-Neu5Ac (compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X on myeloid cells.

HY-145640

Vimnerixin AZD4721; RIST4721	CXCR	Inflammation/Immunology
Vimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease.

HY-D1491

Fast Red Violet LB	Fluorescent Dye	Others
Fast Red Violet LB is a dye for staining tartrate resistant acid phosphatase (TRAP). Fast Red Violet LB can be used for alkaline phosphatase (ALP) activity staining.

HY-N11925

(+)-Osbeckic acid	Others	Cardiovascular Disease
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM.

HY-W403633

Hexahydrohippuric acid	Bacterial	Infection
Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity.

HY-P0311A

LAH4 TFA	Bacterial	Infection
LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.

HY-N10219

Dihydroaltenuene B	Tyrosinase Fungal	Infection
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.

HY-103396

Trimetrexate glucuronate CI-898 glucuronate	Antifolate Bacterial	Cancer Infection
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia.

HY-151680

TAMRA alkyne, 6-isomer	DNA Stain	Others
TAMRA alkyne, 6-isomer is a linker of TAMRA which is a xanthene dye with orange emission that is commonly used for oligonucleotide labeling and amino acid sequencing. The addition of the alkyne groups allows for it to be reacted with an azide for copper-catalyzed Click Chemistry.

HY-146005

Tau-aggregation and neuroinflammation-IN-1	Microtubule/Tubulin	Inflammation/Immunology Neurological Disease
Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats.

HY-135747

Gut restricted-7 1 Publications Verification GR-7	Bacterial	Infection
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice.

HY-135087

Caprylic/Capric Triglyceride 1 Publications Verification	Biochemical Assay Reagents	Others
Caprylic/Capric Triglyceride is the triglycerides and esters prepared from fractionated vegetable oil sources and fatty acids from coconuts and palm kernel oils. Caprylic/Capric Triglyceride possesses excellent oxidation stability. Caprylic/Capric Triglyceride is used as a food additive and used in cosmetics.

HY-N10319

Artepillin C	Others	Cancer
Artepillin C has gastroprotective, anti-inflammatory, antimicrobial, antioxidant, antitumor and choleretic activity. Artepillin C can be isolated from Brazilian green propolis.

HY-107784

Ectoine	Bacterial	Inflammation/Immunology
Ectoine is a natural cell protectant, an amino acid derivate produced by bacteria living under extremely harsh environmental conditions. Ectoine serves as an osmoregulatory compatible solute, increasing the hydration of the skin surface and stabilizing lipid layers, which is useful in skincare. Ectoine demonstrates a good safety profile for the treatment of allergic rhinitis.

HY-109000A

Afabicin disodium Debio 1450 disodium; AFN-1720 disodium	Bacterial	Infection
Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

HY-N7387

3-Oxocholic acid	Endogenous Metabolite	Metabolic Disease
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals.

HY-136607

DiAzK

Others Others

DiAzK is a bifunctional amino acid. DiAzK can be inserted into almost any protein interface with minimal structural perturbation using genetic code expansion.

HY-126967

1-Palmitoyl lysophosphatidic acid	Endogenous Metabolite	Metabolic Disease
1-Palmitoyl lysophosphatidic acid is a lysophosphatidic acid that causes concentration-dependent aggregation of human platelets. 1-Palmitoyl lysophosphatidic acid causes changes in platelet shape, pseudopod development, and particle concentration. 1-Palmitoyl lysophosphatidic acid may induce platelet aggregation by stimulating the release of intracellular Ca.

HY-W050026S

Phenylacetylglutamine-d5 1 Publications Verification NSC 203800-d₅; Phenylacetyl-L-glutamine-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Others
Phenylacetylglutamine-d₅ is the deuterium labeled Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation[1].

HY-148242A

BAY-252	Others	Cancer
BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC₅₀s of 2 μM and 2 μM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used for the research of cancer.

HY-N7443

Gibberellin A1

Others Others

Gibberellin A1 is a kind of plant hormones. Gibberellin A1 is a growth-promoting acids isolated from immature seed of Phaseolus multiflorus.

HY-W176012

Glycolate oxidase-IN-1	Others	Metabolic Disease
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC₅₀ of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1).

HY-118783

2-Hexyl-4-pentynoic acid (±)-2-Hexyl-4-pentynoic acid	HDAC HSP	Neurological Disease
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC₅₀=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1676

Thymolphthalein monophosphate disodium hydrate	Phosphatase	Others
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum.

HY-135283

ABT-546 A-216546	Endothelin Receptor	Endocrinology Cardiovascular Disease
ABT-546 (A-216546) is a potent, highly selective and active endothelin ET_A receptor antagonist with a K_i of 0.46 nM for [¹²⁵I]endothelin-1 binding to cloned human endothelin ET_A. ABT-546 is >25,000-fold more selective for the ET_A receptor than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively.

HY-P1125

4-CMTB 2 Publications Verification	Free Fatty Acid Receptor	Others
4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC₅₀=6.38).

HY-151619

sEH inhibitor-12	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-12 (compound 34) is a sEH inhibitor with an IC₅₀ value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein (FLAP)-mediated leukotriene (LT) biosynthesis with an IC₅₀ value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation.

HY-119435

Triallate	Others	Others
Triallate is a selective preemergence herbicide for the control of wild oats in barley, spring wheat, Durum wheat, winter wheat, and sugar beets. Triallate inhibits fatty acid elongation and surface lipid (wax) biosynthesis.

HY-N3126

Orsellinic acid	Others	Others
Orsellinic acid is a compound produced by Lecanoric acid treated with alcohols. Lecanoric acid is a lichen depside isolated from a Parmotrema tinctorum specimen.

HY-113402

Gamma-glutamylcysteine γ-Glu-Cys	Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels.

HY-155247

Tyrosinase-IN-14	Tyrosinase	Others
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage.

HY-W015399

4-Methylcinnamic acid	Fungal	Infection
4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance. 4-Methylcinnamic acid can improve the potency of cell wall-disrupting agents.

HY-N2920

β-Amyrenonol 11-Oxo-β-amyrin	Cytochrome P450	Cancer Inflammation/Immunology
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.

HY-105033

Irloxacin Pirfloxacin	Bacterial	Infection
Irloxacin (Pirfloxacin) is a quinolone antibacterial agent. Irloxacin shows greater activity with an acid pH. Irloxacin has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. Orally active.

HY-115319

CP-24879 hydrochloride 1 Publications Verification	Ferroptosis	Inflammation/Immunology
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research.

HY-N3287

Methyl 3-hydroxy-4,5-dimethoxybenzoate	Bacterial	Infection
Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H₂O₂.

HY-134424

Propionyl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms.

HY-135259

CAY10580

Prostaglandin Receptor Metabolic Disease

CAY10580 is a potent and selective prostaglandin EP₄ receptor agonist (K_i=35 nM).

HY-P0311

LAH4	Bacterial	Infection
LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.

HY-108034

GET73	Others	Neurological Disease
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus.

HY-W089835

Sodium taurodeoxycholate hydrate 1 Publications Verification	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Sodium taurodeoxycholate hydrate, a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Sodium taurodeoxycholate hydrate activates the S1PR2 pathway in addition to the TGR5 pathway.

HY-147335

6,9,12,15-Hexadecatetraenoic acid-ethyl ester	Others	Cardiovascular Disease
6,9,12,15-Hexadecatetraenoic acid-ethyl ester is an orally active n-1PUFA. 6,9,12,15-Hexadecatetraenoic acid-ethyl ester intake can reduce plasma triglyceride content in mice.

HY-142972

19(S)-HETE	Prostaglandin Receptor	Cardiovascular Disease
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC₅₀ value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.

HY-B0236A

6-Aminocaproic acid hydrochloride EACA hydrochloride; Epsilon-Amino-n-caproic acid hydrochloride; 6-Aminohexanoic acid hydrochloride	Others	Cancer Metabolic Disease
6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

HY-146984

α-Amylase-IN-2	Glucosidase	Inflammation/Immunology
α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivative against α-glucosidase (IC₅₀=1.28 µM) and α-amylase (IC₅₀=3.8 µM) .

HY-116248

Ro 41-5253	RAR/RXR Apoptosis	Cancer
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity.

HY-D0035

MPAC-Br

Fluorescent Dye Others

MPAC-Br is a highly sensitive fluorescent derivatization reagent for carboxylic acids in HPLC.

HY-111345

Epaminurad UR-1102; URC-102	URAT1	Metabolic Disease Inflammation/Immunology
Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a K_i of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research.

HY-108529

BMS493 1 Publications Verification	RAR/RXR	Metabolic Disease
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14874

Topiroxostat 5 Publications Verification FYX-051	Xanthine Oxidase Cytochrome P450	Metabolic Disease
Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC₅₀ value of 5.3 nM and a K_i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.

HY-119518

BMS641 BMS-209641	RAR/RXR	Cancer
BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (K_d, 2.5 nM) that is 100 times higher than that for RARα (K_d, 225 nM) or RARγ (K_d, 223 nM).

HY-B1142

Lipoamide 4 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	Others	Others
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of lipoic acid with ammonia. Lipoamide as a coenzyme to transfer acetyl group and hydrogen in the process of pyruvate deacylation.

HY-P3655

Agelenin	Calcium Channel	Others
Agelenin is a polypeptide composed of 35 amino acids. Agelenin could be isolated from the Agelenidae spider Agelena opulenta. Agelenin has structural similarity to insect-specific calcium channel inhibitor.

HY-D1610

BODIPY FL C5	Fluorescent Dye	Others
BODIPY FL C₅ is a green fluorescent fatty acid. BODIPY FL C₅ can be used as a precursor for the synthesis of various fluorescent phospholipids. BODIPY FL C₅ is relatively insensitive to the environment and fluoresces in both water-soluble and lipid environments.

HY-151505

CysOx2	Fluorescent Dye	Others
CysOx2 is a reaction-based fluorogenic probe for sulfenic acid (Ex/Em: 394/535 nm). CysOx2 can be used for detecting protein cysteine oxidation in living cells.

HY-P3976

Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a blood pressure lowering peptide containing 4 amino acids. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is an angiotensin-converting Enzyme (ACE) inhibitor. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine can be used in research of high blood pressure.

HY-P10007

Z-Gly-Pro-Phe-Leu-CHO Z-GPFL-CHO	Proteasome	Cancer
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (K_i = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC₅₀ = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity).

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Endogenous Metabolite	Inflammation/Immunology
Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects.

HY-108520

HX630

RAR/RXR Apoptosis Cancer

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research.

HY-109591A

Oleoyl coenzyme A lithium Oleoyl-CoA lithium	Biochemical Assay Reagents	Others
Oleoyl coenzyme A (Oleoyl-CoA) lithium is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A lithium has a role as an Escherichia coli metabolite and a mouse metabolite.

HY-136540

Resolvin D3 RvD3	Others	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.

HY-125923

Djenkolic acid	Others	Metabolic Disease
Djenkolic acid is a sulfur-containing non-protein amino acid naturally found in the djenkol beans of the Southeast Asian plant Archidendron jiringa. Djenkolic Acid often causes renal injury, including hypersensitivity to or a direct toxic effect of a djenkol bean metabolite, resulting in acute kidney injury and/or urinary tract obstruction by djenkolic acid crystals, sludge, and/or possible ureteral spasms.

HY-109591

Oleoyl Coenzyme A	Biochemical Assay Reagents	Others
Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite.

HY-B1899A

Taurodeoxycholic acid sodium hydrate Sodium taurodeoxycholate monohydrate	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway.

HY-108531

ER 50891	RAR/RXR	Cancer
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.

HY-146981

α-Glucosidase-IN-3

Glucosidase Inflammation/Immunology

α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivativ eagainst α-glucosidase(IC₅₀=0.35 µM) and α-amylase.

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Endogenous Metabolite	Neurological Disease
Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models.

HY-144701

SABA1	Antibiotic Bacterial	Infection Inflammation/Immunology
SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC₅₀ of 4.0 µM against E. coli ACC.

HY-101887

Calcein Blue 1 Publications Verification	Fluorescent Dye	Others
Calcein Blue, a membrane-impermeant fluorescent dye, is a coumarin derivative that contains an iminodiacetic acid structure. Calcein Blue is also a metallofluorochromic indicator.

HY-N7692

Polyporusterone A	Others	Others
Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis).

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.

HY-143712

Allolithocholic acid	Endogenous Metabolite	Metabolic Disease
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver.

HY-P10110

retro-inverso TAT-Beclin 1 (D-amino acid)	Autophagy	Neurological Disease
retro-inverso TAT-Beclin 1 D-amino acid is has higher activity and resistance to proteolytic degradation in vivo compared to L-amino acids peptide. TAT-Beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice.

HY-133621

9,10-Dichlorostearic acid	Others	Cancer
9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. 9,10-Dichlorostearic acid can cause membrane damage by inducing leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro.

HY-N7693

Polyporusterone B	Others	Others
Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis).

HY-126995

Glycohyodeoxycholic acid	Endogenous Metabolite	Metabolic Disease
Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation.

HY-Y0123

DL-Tyrosine	Others	Neurological Disease
DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine).

HY-100978

(±)-Hexanoylcarnitine chloride DL-Hexanoylcarnitine chloride	Endogenous Metabolite	Metabolic Disease
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways.

HY-D1098A

SYBR Green II (Ionic form)	Fluorescent Dye	Others
SYBR Green II (Ionic form) is a fluorescent nucleic acid dye that mainly binds single-stranded nucleotides. SYBR Green II is sensitive to oligonucleotides or larger nucleic acid polymers in a variety of cells and gels. SYBR Green II can be used to study cell structure, membrane integrity or function, and cell cycle distribution. Wavelength 484/515 nm.

HY-D1098

SYBR Green II	Fluorescent Dye	Others
SYBR Green II is a fluorescent nucleic acid dye that mainly binds single-stranded nucleotides. SYBR Green II is sensitive to oligonucleotides or larger nucleic acid polymers in a variety of cells and gels. SYBR Green II can be used to study cell structure, membrane integrity or function, and cell cycle distribution. Wavelength 484/515 nm.

HY-147678

GPR40 agonist 5	Free Fatty Acid Receptor	Metabolic Disease
GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC₅₀ of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice. GPR40 agonist 5 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Others	Metabolic Disease Neurological Disease
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice.

HY-139134

S-2E	HMG-CoA Reductase (HMGCR) Acetyl-CoA Carboxylase	Cardiovascular Disease
S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.

HY-122464A

Jasmonic acid (-)-Jasmonic acid	Molecular Glues	Others
Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of α-Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules.

HY-122928

Rosamultic acid	Apoptosis Caspase	Cancer
Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases.

HY-W010410

Oct-1-en-3-ol	Others	Metabolic Disease Neurological Disease
Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling.

HY-113259

7α-Hydroxy-4-cholesten-3-one	Endogenous Metabolite	Metabolic Disease
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.

HY-N7392

Acetoacetyl-CoA	Biochemical Assay Reagents	Metabolic Disease
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids.

HY-147331

Oseltamivir acid methyl ester	Antibiotic	Neurological Disease
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1).

HY-138200

Cy5 maleimide Cyanine5 maleimide	Fluorescent Dye DNA Stain	Others
Cy5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	PKC TRP Channel Endogenous Metabolite	Neurological Disease
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity.

HY-15209

Repaglinide

AG-EE 623ZW
Potassium Channel Metabolic Disease Cancer

Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.

HY-N0728

α-Linolenic acid 3 Publications Verification	PI3K Akt	Cancer Cardiovascular Disease
α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.

HY-107613A

R 59-022 hydrochloride 1 Publications Verification DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride	PKC 5-HT Receptor	Cancer Infection Inflammation/Immunology
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

HY-W142631

4-(Phenylazo)diphenylamine	Fluorescent Dye	Cancer
4-(Phenylazo)diphenylamine is an excellent colorimetric indicator for the accurate determination of the concentration for a variety of strong bases, Lewis acids, and hydride reducing agents.

HY-114883A

Homocarnosine TFA L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA	GABA Receptor Endogenous Metabolite	Neurological Disease
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation.

HY-135425

10,12-Tricosadiynoic acid 3 Publications Verification	Acyltransferase	Metabolic Disease
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism. 10,12-Tricosadiynoic acid is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N9210

1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid	Others	Cancer
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid, a ellagic acid derivative of Agrostistachys hookeri, exhibits activity against cultured P-388 lymphocytic leukemia cells.

HY-W016868

3-Chloro-5-hydroxybenzoic acid	Others	Metabolic Disease
3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC₅₀ of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity.

HY-100781

D-AP4 D-APB; D-2-Amino-4-phosphonobutyric acid	iGluR	Neurological Disease
D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co²⁺ influx in cultured cerebellar granule cells (IC₅₀ ≥ 100 μM).

HY-149832

Anticancer agent 114	Proteasome	Cancer
Anticancer agent 114 is a potent and orally active dipeptide boronic acid ester proteasome inhibitor with an IC₅₀ value of 2.2 nM. Anticancer agent 114 has antiproliferative activity against the RPMI-8226 cells. Anticancer agent 114 can be used in research of multiple myeloma.

HY-139014

N-ε-propargyloxycarbonyl-L-lysine H-L-Lys(Poc)-OH	Fluorescent Dye	Cancer
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals. N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N3997

Nostosin G	Ser/Thr Protease	Cancer Infection Metabolic Disease
Nostosin G is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. Nostosin G has potent trypsin inhibitory property with an IC₅₀ value of 0.1 μM.

HY-D0133

NBD-X acid	Fluorescent Dye	Others
NBD-X acid is a fluorescent probe for the study of fatty acids and sterols. NBD-X acid provides better yields for labelling biopolymers compared to NBD chloride and fluoride. The fluorescence spectrum of the NBD derivative is highly sensitive to the environment and the fluorescence intensity is significantly reduced in aqueous solutions.

HY-148198

S1P5 receptor agonist-1

LPL Receptor Inflammation/Immunology

S1P5 receptor agonist-1 (example 6) is a potent and selective agonist of S1P₅ receptor with an EC₅₀ value of 20 nM.

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model.

HY-N12203

5-Deoxypulchelloside I

Others Others

5-Deoxypulchelloside I is a magnoside glycoside that can be isolated from the aerial parts of the Lamiaceae plant Eremostachys laciniata.

HY-107613

R 59-022 1 Publications Verification DKGI-I; Diacylglycerol kinase inhibitor I	PKC 5-HT Receptor	Inflammation/Immunology
R 59-022 (DKGI-I) is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

HY-B1557A

Betazole dihydrochloride Ametazole dihydrochloride	Histamine Receptor	Metabolic Disease
Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity.

HY-N8139

2-Amino-3-carboxy-1,4-naphthoquinone	Others	Metabolic Disease
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria.

HY-123297

TUG-469	Free Fatty Acid Receptor	Metabolic Disease
TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC₅₀ value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.

HY-146122

ATX inhibitor 19

Phosphodiesterase (PDE) Cancer

ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 156 nM.

HY-135772

12-Ketodeoxycholic acid 12-Ketolithocholic acid	Endogenous Metabolite	Metabolic Disease
12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications	Ferroptosis Endogenous Metabolite	Cancer
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis.

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.

HY-B0283A

Acipimox sodium K-9321 sodium	Others	Metabolic Disease
Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.

HY-12511

SKF-86002 2 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.

HY-P2537

Apelin-12	Apelin Receptor (APJ) HIV	Others
Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.

HY-B0283

Acipimox 1 Publications Verification K-9321	Others	Metabolic Disease
Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.

HY-103138

(Rac)-WAY-161503 hydrochloride	5-HT Receptor	Metabolic Disease Neurological Disease
(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects.

HY-N3394

Lecanoric acid	Others	Infection
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase.

HY-N9676

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside	Others	Others
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid.

HY-103138A

(Rac)-WAY-161503	5-HT Receptor	Metabolic Disease Neurological Disease
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.

HY-W441007

DSPE-Mal	Liposome	Cancer Inflammation/Immunology
DSPE-MAL is a thiol reactive a phospholipid compound. DSPE-MAL has two saturated fatty acids and can self-assemble in water to form lipid bilayer. DSPE-MAL can be used to prepare liposomes as agent nanocarrier.

HY-138650

Monocaprylin Glyceryl monocaprylate; Sefsol 318	Bacterial	Inflammation/Immunology
Monocaprylin (Glyceryl monocaprylate), a monoglyceride of caprylic acid, exhibits an excellent antibacterial activity. Monocaprylin inhibits a variety of foodborne pathogenic and spoilage microorganisms and has the potential for an alternative food preservative research.

HY-N8359

Questinol

Others Metabolic Disease

Questinol is a palmitic acid that can be isolated from Talaromyces stipitatus. Questinol has signi?cant anti-obesity activity in zebra?sh larvae.

HY-Y0445A

Sodium dichloroacetate 10+ Cited Publications	PDHK Reactive Oxygen Species NKCC Apoptosis	Cancer
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor.

HY-B1557

Betazole 1 Publications Verification Ametazole	Histamine Receptor	Metabolic Disease
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity.

HY-139692

EAAT2 activator 1	EAAT	Neurological Disease
EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently.

HY-148087

AZD5462	Others	Cardiovascular Disease
AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.

HY-105120A

Vapiprost hydrochloride	Others	Others
Vapiprost hydrochloride is a thromboxane A2 receptor antagonist. Vapiprost inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC₅₀ of less than 2.1×10^-8 M.

HY-118347

Aspartame acesulfame	Others	Neurological Disease
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%).

HY-117695

AQC 1 Publications Verification 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate	Fluorescent Dye	Others
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels.

HY-18062

Pyrimethamine 5 Publications Verification Pirimecidan; Pirimetamin; RP 4753	Antifolate Parasite	Infection
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate.

HY-B1124A

Fipexide hydrochloride 1 Publications Verification	Adenylate Cyclase Dopamine Transporter	Neurological Disease
Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is a nootropic agent. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research.

HY-103305

cis-Ned19

Others Cancer

cis-Ned19 is a chemical probe. cis-Ned19 blocks NAADP signaling and fluorescently labeled NAADP receptors in cell.

HY-101559

10-Nitrooleic acid CXA-10	Others	Inflammation/Immunology
10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles.

HY-N7624

Methyl oleanonate 3-Oxoolean-12-en-28-oic acid methyl ester	PPAR	Cancer
Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects.

HY-121450

Lavoltidine Loxtidine; AH-234844	Histamine Receptor	Cancer
Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia.

HY-W018555

D-Cysteine	Endogenous Metabolite Bacterial	Infection Neurological Disease
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis*.

HY-N0121

Sesamin 4 Publications Verification	Others	Neurological Disease
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.

HY-B1124

Fipexide 1 Publications Verification	Adenylate Cyclase Dopamine Transporter	Neurological Disease
Fipexide, a parachloro-phenossiacetic acid derivative, is a nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research.

HY-119366

S18-000003	ROR	Inflammation/Immunology
S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC₅₀ of <30 nM towards human RORγt in competitive binding assays. S18-000003 shows selectivity for RORγt over other ROR family members (IC₅₀>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations.

HY-103331

COR170	Cannabinoid Receptor	Inflammation/Immunology Neurological Disease
COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a K_i value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection.

HY-118149A

(±)9-HpODE	Bacterial Fungal Parasite	Infection
(±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens.

HY-N7062

JNJ-1661010 Takeda-25	FAAH	Neurological Disease
JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC₅₀s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics.

HY-W133891

Peptone from soya Peptones, soybean	Biochemical Assay Reagents	Others
Peptone from soya (Peptones, soybean) is a peptone that is commonly used as a component of culture medium. Peptone from soya can be used in microbiology and cell culture to provide needed sources of nitrogen, carbon and other nutrients. Peptone from soya stimulates/regulates cyclic arachidonic acid biosynthesis. Peptone from soya also exerts enteric cell activity in jejunum of piglets through this mechanism.

HY-135808

BIZ 114	NF-κB	Inflammation/Immunology
BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases.

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.

HY-N9065

12-Oxograndiflorenic acid	Others	Others
12-Oxograndiflorenic acid is a natural product that can be isolated from vegetative Ambrosia hispida. Synonyms is ent-12-oxokaura-9(11),16-dien-19-oic acid.

HY-108641

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.

HY-147368

PKM2 activator 2	Pyruvate Kinase	Cancer
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC₅₀ value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells.

HY-110334

FFN 206 dihydrochloride	Others	Others
FFN 206 dihydrochloride, a fluorescent probe, is used as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent K_m of 1.16 μM. FFN 206 dihydrochloride is capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles.

HY-112942

CMP-Sialic acid CMP-Neu5Ac	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

HY-125801

3-Oxo-5β-cholanoic acid Dehydrolithocholic acid; 3-oxoLCA	ROR	Inflammation/Immunology
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (K_d=1.13 μM).

HY-P3695

VSPPLTLGQLLS	FGFR	Cancer
VSPPLTLGQLLS is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation.

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents	Endocrinology
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease.

HY-N7059

Lactobionic acid	Bacterial	Infection
Lactobionic acid is a bionic acid naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties.

HY-B2246

L-Carnitine hydrochloride 5+ Cited Publications (R)-Carnitine hydrochloride; Levocarnitine hydrochloride	Endogenous Metabolite	Metabolic Disease Cancer
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-119524

Clofibride	Others	Metabolic Disease
Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo.

HY-117549

Ibrolipim NO-1886	Others	Cardiovascular Disease
Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL)-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects.

HY-118469

Phanquinone 11925 C; Entronon	Others	Others
Phanquone (11925 C; Entronon) derives from a hydride of a 4,7-phenanthroline. Phanquone is applied as an original precolumn derivatization reagent for amino acids.

HY-139606

VCP/p97 inhibitor-1	p97	Cancer
VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC₅₀ of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

HY-151780

Fmoc-L-Dap(Pentynoyl)-OH	ADC Linker	Others
Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Dap(Pentynoyl)-OH serves as an amino acid building block for introducing alkyne functions into peptide sequences by standard Fmoc/tBu protocols. The alkyne residue can be engaged for copper catalyzed click reaction with organic azides or with tetrazines for copper-free conjugations.

HY-153219A

P-CAB agent 2	Potassium Channel	Endocrinology
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H⁺/K⁺-ATPase activity with an IC₅₀ value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC₅₀ value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.

HY-W009749

L-Cystathionine	Endogenous Metabolite Apoptosis	Cardiovascular Disease
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.

HY-147668

α-Synuclein inhibitor 6	Others	Neurological Disease
α-Synuclein inhibitor 6 (compound 3ge) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 1.70 μM and inhibition ratio at 30 μM of 94.4%.

HY-126437D

Poly-L-lysine hydrobromide (MW ＞300000)	Biochemical Assay Reagents	Others
Poly-L-lysine hydrobromide (MW 150000-300000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine hydrobromide (MW 150000-300000) has good biocompatibility. Poly-L-lysine hydrobromide (MW 150000-300000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface.

HY-108599

DCP-LA 2 Publications Verification FR236924	PKC CaMK Phosphatase Apoptosis	Neurological Disease
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.

HY-N12012

11-Oxomogroside II A2 11-Dehydroxy-mogroside IIA2 O-rhamnoside	Others	Others
11-Oxomogroside II A2 (11-Dehydroxy-mogroside IIA2 O-rhamnoside) (compound 101) is a mogroside isolated from the fruit of Luo Han Guo.

HY-N8060A

Orotidine 5′-monophosphate trisodium Orotidine monophosphate trisodium; Orotidylic acid trisodium	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT).

HY-113335

Trihydroxycholestanoic acid Coprocholic acid	Endogenous Metabolite	Inflammation/Immunology
Trihydroxycholestanoic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Refsum Disease, D Bifunctional Protein Deficiency and Infantile Refsum Disease.

HY-147666

α-Synuclein inhibitor 4	Others	Neurological Disease
α-Synuclein inhibitor 4 (compound 3gh) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 0.98 μM and inhibition ratio at 30 μM of 91.2%.

HY-126015

P053	Acyltransferase	Metabolic Disease
P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC₅₀ of 0.5 μM. P053 acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle. Whole-body adiposity regulator.

HY-107412

Proteasome inhibitor IX PS-IX; AM114	Proteasome	Cancer
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC₅₀ value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53^+/+ cells growth inhibitory activity with an IC₅₀ value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity.

HY-D1543

Pyronin B	DNA Stain	Infection
Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor.

HY-145578

Linaprazan glurate X842	Others	Inflammation/Immunology
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate exhibits several advantageous properties, such as fast onset, high in vivo potency and/or long duration of action. Linaprazan glurate is useful in the research of gastrointestinal inflammatory diseases and peptic ulcer diseases (extracted from patent WO2010063876A1).

HY-112942A

CMP-Sialic acid sodium salt CMP-Neu5Ac sodium salt	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

HY-136373

Metazachlor	Others	Others
Metazachlor is a herbicide of the chloroacetamide class. Metazachlor is an inhibitor of the synthesis of long chain fatty acids and has an effect on cell division or tissue differentiation in the germinating and emerging weed target species.

HY-P0239A

HA Peptide TFA 5+ Cited Publications	Influenza Virus	Inflammation/Immunology
HA Peptide (TFA) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide (TFA) is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry.

HY-115521

Jarin-1 1 Publications Verification	Others	Others
Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor with an IC₅₀ of 3.8 μM. Jarin-1 specific inhibits bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis in Arabidopsis and other plants.

HY-N0325

DL-Methionine	Parasite	Infection Inflammation/Immunology
DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills *H. rostochiensis* on potato plants.

HY-126415

Magnesium Lithospermate B	Others	Inflammation/Immunology Neurological Disease Cardiovascular Disease
Magnesium Lithospermate B, a derivative of caffeic acid tetramer, and is extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinﬂammation and attenuates neurodegeneration.

HY-153219

P-CAB agent 2 hydrochloride	Potassium Channel	Endocrinology
P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H⁺/K⁺-ATPase activity with an IC₅₀ value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC₅₀ value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.

HY-136408

Malonyl Coenzyme A lithium	Mitochondrial Metabolism	Metabolic Disease
Malonyl Coenzyme A lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). High Malonyl Coenzyme A lithium concentrations suppress fatty acid oxidation, while low Malonyl Coenzyme A lithium concentrations are permissive for fat oxidation.

HY-B1529A

Citric acid triammonium 2 Publications Verification Triammonium citrate	Endogenous Metabolite Apoptosis	Cancer Infection Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Citric acid triammonium (Triammonium citrate) is formed by Citric acid (HY-N1428) reacting with ammonia in a molar ratio of 1:3. Citric acid triammonium can be used as the carbon source to prepare carbon quantum dots (CDs). Citric acid triammonium with higher nitrogen components might promote the nitrogen-based functional groups in CDs, leading to a more efficient emission-color tunability.

HY-147669

α-Synuclein inhibitor 7	Others	Neurological Disease
α-Synuclein inhibitor 7 (compound 3gf) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 1.95 μM and inhibition ratio at 30 μM of 85.8%.

HY-150787

BMS-986339	FXR Cytochrome P450	Metabolic Disease
BMS-986339 is an orally active, potent FXR agonist. BMS-986339 forms H-bond with His298 and ASN287 residues. BMS-986339 can be used in the research of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH), anti-fibrosis.

HY-14380

PF-3845 1 Publications Verification	FAAH Autophagy	Inflammation/Immunology Cancer
PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH), with a K_i of 0.23 µM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition.

HY-133027

Myristyl nicotinate Tetradecyl nicotinate	Others	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier.

HY-108477

TMPyP4 tosylate 1 Publications Verification TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2.

HY-14973

Vidupiprant AMG 853	Prostaglandin Receptor	Inflammation/Immunology
Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC₅₀s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment.

HY-114360

Taurohyodeoxycholic acid	Endogenous Metabolite	Metabolic Disease
Taurohyodeoxycholic acid is the tauroconjugated form of Hyodeoxycholic acid (HDCA, a dihydroxylated natural bile acid). Taurohyodeoxycholic acid induces a biliary phospholipid secretion and suggests a hepatoprotective potential. Taurohyodeoxycholic acid also can promote gallstone dissolution.

HY-147667

α-Synuclein inhibitor 5	Others	Neurological Disease
α-Synuclein inhibitor 5 (compound 4aa) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 1.22 μM and inhibition ratio at 30 μM of 94.3%.

HY-150766

KPC-2-IN-1	Bacterial	Infection
KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with K_i of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics.

HY-144635

Nrf2-ARE/hMAO-B/QR2 modulator 1	Monoamine Oxidase Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices.

HY-W396714

Succinic acid sodium Wormwood acid sodium	Potassium Channel TET Protein	Neurological Disease
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten‑eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.

HY-P3732

RGD-4C	Integrin	Cancer
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models.

HY-138903

L-Homocysteic acid L-HCA	iGluR	Neurological Disease
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC₅₀: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.

HY-P3695A

VSPPLTLGQLLS TFA	FGFR	Cancer
VSPPLTLGQLLS TFA is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS TFA inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation.

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Cancer Infection
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects.

HY-100834

5,7-Dichlorokynurenic acid 5,7-DCKA	iGluR	Neurological Disease
5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a K_B of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures.

HY-B1099

Hycanthone 2 Publications Verification	DNA/RNA Synthesis Topoisomerase Parasite	Infection
Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K_D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent.

HY-126437B

Poly-L-lysine hydrobromide (MW 70000-150000)	Biochemical Assay Reagents	Others
Poly-L-lysine (hydrobromide) (MW 70000-150000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine (hydrobromide) (MW 70000-150000) has good biocompatibility. Poly-L-lysine (hydrobromide) (MW 70000-150000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface.

HY-B0550

Bismuth Subsalicylate Bismuth oxysalicylate; Bismuth(III) salicylate basic	PGE synthase	Neurological Disease
Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al.

HY-132610

Givosiran ALN-AS1	Small Interfering RNA (siRNA)	Neurological Disease
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria.

HY-W019870

Glufosinate ammonium	Others	Neurological Disease
Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity.

HY-N2417

Stearyl glycyrrhetinate	Bacterial	Infection
Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects.

HY-116281

ICI D1542	Prostaglandin Receptor	Cardiovascular Disease
ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP-receptor). ICI D1542 is effective at preventing thrombus formation by redirection of arachidonic acid metabolism.

HY-13212

(Z)-2-Decenoic acid cis-2-Decenoic acid	Others	Cancer
(Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development.

HY-B0007S

Baclofen-d4	GABA Receptor	Neurological Disease
Baclofen-d₄ is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].

HY-B1684

Mebrofenin SQ 26962	Biochemical Assay Reagents	Others
Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function.

HY-121238

Hyocholic Acid	Others	Metabolic Disease
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .

HY-116374A

Glycolithocholic acid sodium Lithocholylglycine sodium	Others	Metabolic Disease
Glycolithocholic acid (Lithocholylglycine) sodium is the sodium salt of Glycolithocholic acid. Glycolithocholic acid is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC).

HY-33009

AS057278	Others	Neurological Disease
AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC₅₀ value of 0.91 μM and EC₅₀ of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia.

HY-130027

HKOCl-4 1 Publications Verification BXY2142	Fluorescent Dye	Others
HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. E_x: 530 nm; E_m 557 nm.

HY-128144

Lalistat 2

Others Metabolic Disease

Lalistat 2 is a specific inhibitor of lysosomal acid lipase (LAL) with no effect on other forms of lipase.

HY-N6036

Ganoderic acid F 1 Publications Verification	Others	Cancer
Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress.

HY-121140

AZ1729	Free Fatty Acid Receptor	Metabolic Disease
AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in G_i-mediated pathways, but not at those transduced by G_q/G₁₁. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2.

HY-147304

BPH-1086

Bacterial Others

BPH-1086 (compound 10) is an IspH inhibitor, IspH domain fused with ribosomal protein S1 (RPS1) can bind to mRNA or form part of the bacterial ribosome.

HY-15870

SR 11302 4 Publications Verification	AP-1	Cancer Inflammation/Immunology
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation.

HY-156280

RARα antagonist 1

RAR/RXR Endocrinology

RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α(RARα) antagonist, with the IC₅₀ of 4.6nM.

HY-109124

Taniborbactam VNRX-5133	Bacterial	Infection
Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria.

HY-W193545A

EGR240	Others	Cancer Inflammation/Immunology
EGR240 is a branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. EGR240 can be used for the research of cancer, rheumatoid arthritis, and bone disease.

HY-B0007

Baclofen 4 Publications Verification	GABA Receptor	Neurological Disease
Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-113638

CVT-11127 GS-456332	Stearoyl-CoA Desaturase (SCD) Apoptosis	Cancer
CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.

HY-121422

JZP-361	MAGL Histamine Receptor	Inflammation/Immunology
JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC₅₀ of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research.

HY-131041

Ned-K	Calcium Channel	Cardiovascular Disease
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca²⁺ oscillations in cardiomyocytes.

HY-N2683

5-O-Methylnaringenin

Others Others

5-O-Methylnaringenin is a flavonoid compound. 5-O-Methylnaringenin is isolated from chloroacetic acid .

HY-P1535A

Secretin, porcine TFA Porcine secretin TFA	Secretin Receptor	Inflammation/Immunology
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.

HY-147547

SV5	Amyloid-β	Neurological Disease
SV5 is a potent anti-Alzheimer agent. SV5 can significantly protect SHSY-5Y cells against Aβ_1-42-induced death. SV5 shows moderate antioxidant and good neuroprotective activities. SV5 shows the high stability in human plasma and the best pharmacological profile.

HY-W019870A

Glufosinate	Others	Neurological Disease
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity.

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation.

HY-127143

Sterculic acid	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM.

HY-135130

Bischloroanthrabenzoxocinone (-)-BABX	Bacterial	Infection
Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis.

HY-131967

CD73-IN-4	CD73	Cancer Inflammation/Immunology
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC₅₀ of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology.

HY-D0841

Guanidine thiocyanate 2 Publications Verification GTC	Endogenous Metabolite	Cancer
Guanidine thiocyanate is a chaotropic agent. Guanidine thiocyanate can be used as a protein denaturant and a nucleic acid protector in the extraction of DNA and RNA from cells.

HY-50202A

Etomoxir sodium salt 55+ Cited Publications (R)-(+)-Etomoxir sodium salt	Apoptosis	Metabolic Disease Cancer
Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

HY-125469

ICA-105665 PF-04895162	Potassium Channel	Neurological Disease
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC₅₀ of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects.

HY-151852

9AzNue5Ac	Endogenous Metabolite	Cardiovascular Disease
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity.

HY-121132

Butibufen	Others	Inflammation/Immunology
Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.

HY-106991A

Amustaline dihydrochloride S-303 dihydrochloride	HIV Bacterial	Infection
Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products).

HY-N12240

Oleanolic aldehyde	Bacterial	Infection
Oleanolic aldehyde is an antimicrobial compound used to inhibit oral bacteria. Oleanolic aldehyde inhibits Streptococcus mutans and Porphyromonas gingivalis, which are associated with dental caries and periodontal disease, with minimum inhibitory concentrations (MICs) of 488 μg/mL and 250 μg/mL, respectively.

HY-109124A

Taniborbactam hydrochloride 4 Publications Verification VNRX-5133 hydrochloride	Bacterial	Infection
Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam hydrochloride has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria.

HY-N0301

Thiocolchicoside	GABA Receptor	Inflammation/Immunology Neurological Disease
Thiocolchicoside is a competitive γ-aminobutyric acid type A (GAB_AA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties.

HY-N12207

Neohelmanthicin C

Others Others

Neohelmanthicin C is a phenylpropionic acid compound.

HY-P1535

Secretin, porcine Porcine secretin acetate	Secretin Receptor	Inflammation/Immunology
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.

HY-D1697

OGDA

Fluorescent Dye Infection

OGDA is a green fluorescent D-amino acid. OGDA is suitable for labeling peptidoglycan in Gram-positive and Gram-negative bacteria.

HY-148335

IRG1-IN-1	Others	Cancer Infection Inflammation/Immunology
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases.

HY-B0218

Orlistat 5+ Cited Publications Tetrahydrolipstatin; Ro-18-0647	Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect.

HY-B0007C

Baclofen hydrochloride	GABA Receptor	Neurological Disease
Baclofen hydrochloride, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen hydrochloride mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen hydrochloride has high blood brain barrier penetrance. Baclofen hydrochloride has the potential for muscle spasticity research.

HY-113350

Thromboxane A2 TXA2	Prostaglandin Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses.

HY-W141825

N-Acetyl-DL-phenylalanine β-naphthyl ester	Fluorescent Dye	Infection Metabolic Disease
N-Acetyl-DL-phenylalanine β-naphthyl ester is an aromatic amino acid ester, which functions as a chromogenic substrate for chymotrypsin and microbial serine proteases such as subtilisin.

HY-Y1310

Sodium alginate	Biochemical Assay Reagents	Others
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects.

HY-131615

TPC2-A1-P 1 Publications Verification	Sodium Channel	Others
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC₅₀ of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na²⁺ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.

HY-148682

18β-Glycyrrhetyl-3-O-sulfate Glycyrrhetic acid 3-O-hydrogen sulfate	11β-HSD Drug Metabolite	Metabolic Disease Inflammation/Immunology
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC₅₀ of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research.

HY-19594

Teclozan WIN 13146	Parasite	Infection
Teclozan (WIN 13146) is an antiprotozoal agent, class in benzylamine derivatives. Teclozan intervenes in the phospholipid metabolism preventes the formation of arachidonic acid. Teclozan acts in the intestinal lumen being effective in Anti-G. intestinalis. Teclozan can be used for the research of protozoan infections.

HY-153264

TAS2R14 agonist-1

Others Others

TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM.

HY-P3539

Exendin-4 (3-39)	GCGR	Endocrinology Neurological Disease
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.

HY-B0310

Nizatidine	Histamine Receptor	Cancer Endocrinology Inflammation/Immunology
Nizatidine is a potent and orally active histamine H₂ receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models.

HY-151388

hMAO-B/MB-COMT-IN-1	Monoamine Oxidase COMT	Neurological Disease
hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC₅₀s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).

HY-P3916

GVLSNVIGYLKKLGTGALNAVLKQ	Bacterial	Infection Inflammation/Immunology
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candida albicans.

HY-W019710

(E,E)-RGFP966

HDAC Neurological Disease

(E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease.

HY-W104477

3-Fluoro-L-tyrosine	Others	Metabolic Disease
3-Fluoro-L-tyrosine is a tyrosine analogue, inhibits transamination by tyrosine aminotransferase (TAT). And 3-FluoroL-tyrosine has been shown to be biologically incorporated into proteins in place of tyrosine. 3-Fluoro-L-tyrosine pretends to be the substrate of rat liver tyrosine aminotransferase, markedly disturbs the Tyr-TAT association.

HY-P3502

Zilucoplan RA101495; RA3193	Complement System	Inflammation/Immunology
Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM).

HY-103462

TC-F2	FAAH	Cancer Inflammation/Immunology Metabolic Disease
TC-F2 is a reversible non-covalent binding inhibitor of fatty acid amide hydrolase (FAAH) with an IC₅₀ of 28 nM. FAAH is involved in many human diseases, particularly cancer, pain and inflammation as well as neurological, metabolic and cardiovascular disorders.

HY-149270

COX-2-IN-31	COX	Inflammation/Immunology
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC₅₀=60 nM) and 5-LOX (IC₅₀=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(K_i=48.9 nM) and hCA XII(K_i=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity.

HY-Y1620

3-(3,4-Dimethoxyphenyl)propanoic acid	Others	Cardiovascular Disease
3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias.

HY-N3848

Ermanin	Bacterial COX NO Synthase Influenza Virus	Infection Inflammation/Immunology Cardiovascular Disease
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.

HY-100976

LUF6283	Hydroxycarboxylic Acid Receptor (HCAR)	Metabolic Disease
LUF6283 is a potent and orally active HCA(2) partial agonist, with a K_i of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect.

HY-P4115

CooP	FABP	Cancer
CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles.

HY-N7512

Asimilobine	Dopamine Receptor 5-HT Receptor Parasite	Cancer Infection
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

HY-W013766

Pipemidic acid trihydrate	Bacterial Antibiotic	Infection
Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections.

HY-133180

YW1128	Wnt β-catenin	Metabolic Disease
YW1128 (compound 3a) is a potent Wnt/β-Catenin inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism.

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Inflammation/Immunology Cardiovascular Disease
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.

HY-109854A

(R)-Lisofylline (R)-Lisophylline	STAT	Metabolic Disease Inflammation/Immunology
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC₅₀ of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.

HY-B1278B

(±)-α-Tocopherol acetate (±)-Vitamin E acetate	Biochemical Assay Reagents	Infection
(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases.

HY-B1746

Pyridoxamine 5′-phosphate	Endogenous Metabolite	Neurological Disease
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate.

HY-N10225

Thielavin A	Prostaglandin Receptor	Endocrinology Cardiovascular Disease
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration.

HY-145243

PDPOB	Apoptosis	Others
PDPOB is a phenyl carboxylic acid derivative. PDPOB displays protective roles against OGD/R-evoked multiaspect neuronal deterioration in SH-SY5Y cells, as evidenced by alleviated mitochondrial dysfunction, oxidative stress, and apoptosis. PDPOB has the potential for the research of cerebral ischemia.

HY-151390

hMAO-B/MB-COMT-IN-2	Monoamine Oxidase COMT	Neurological Disease
hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC₅₀s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).

HY-146124

ATX inhibitor 21

Phosphodiesterase (PDE) Cancer

ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 3490 nM.

HY-116374

Glycolithocholic acid Lithocholylglycine	Endogenous Metabolite	Inflammation/Immunology
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC).

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa.

HY-125818

Cytidine-5'-triphosphate 2 Publications Verification Cytidine triphosphate; 5'-CTP	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite	Cancer Infection
Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.

HY-N1429

Taurochenodeoxycholic acid sodium 1 Publications Verification 12-Deoxycholyltaurine sodium	Apoptosis Endogenous Metabolite	Inflammation/Immunology
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.

HY-149263

HAA-09	Influenza Virus Virus Protease	Infection
HAA-09 is an orally active and potent anti-influenza agent, targeting the influenza PB2_cap binding domain. HAA-09 displays potent anti-influenza A virus activity, with an EC₅₀ of 0.03 μM. HAA-09 shows polymerase inhibition, with an IC₅₀ of 0.06±0.004 μM. HAA-09 blocks virus replication without causing obvious cytotoxicity.

HY-B0172A

Isoallolithocholic acid 1 Publications Verification 3β-Hydroxy-5α-cholanic acid	Others	Inflammation/Immunology
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation.

HY-133147

HDAC3/6-IN-2	HDAC Apoptosis	Cancer
HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC₅₀ values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin.

HY-D1650

BDP 630/650 carboxylic acid	Fluorescent Dye	Others
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λ_ex=630 nm, λ_em=650 nm).

HY-155282

FASN-IN-6	Fatty Acid Synthase (FASN) Bacterial	Inflammation/Immunology
FASN-IN-6 (compound 44) is a potent fatty acid biosynthesis (FAB) inhibitor. FASN-IN-6 is an antibacterial agent with MICs of 1 μg/mL and 4 μg/mL for S. aureus ATCC 25923 and E. faecalis ATCC 29212, respectively.

HY-113133

Kojibiose	Glucosidase	Infection Metabolic Disease Inflammation/Immunology
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo.

HY-131614

TPC2-A1-N 2 Publications Verification	Calcium Channel	Others
TPC2-A1-N is a powerful and Ca²⁺-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca²⁺ responses from TPC2 (EC₅₀=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells.

HY-145294

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation.

HY-N2027

Taurochenodeoxycholic acid 1 Publications Verification 12-Deoxycholyltaurine	Apoptosis Endogenous Metabolite	Inflammation/Immunology
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.

HY-136276

DMNB-caged-Serine	Others	Others
DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation.

HY-B0305

Roxatidine acetate	Histamine Receptor	Cancer Metabolic Disease Inflammation/Immunology
Roxatidine acetate is a potent, selective, competitive and orally active histamine _H2-receptor antagonist. Roxatidine acetate has antisecretory potency against gastric acid secretion. Roxatidine acetate can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine acetate has antitumor activity.

HY-N12216

Cyanidin 3-sophoroside-5-glucoside	Others	Others
Cyanidin 3-sophoroside-5-glucoside is the main anthocyanin in purple-fleshed sweet potato and affects the antioxidant activity of purple-fleshed sweet potato.

HY-143906

URAT1 inhibitor 2	URAT1	Inflammation/Immunology
URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC₅₀ values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated ¹⁴C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout.

HY-108571

CP-775146	PPAR	Metabolic Disease
CP-775146 is a selective PPARα agonist that binds strongly to the PPARα ligand. CP-775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway.

HY-110354

UCM05 G28UCM	Fatty Acid Synthase (FASN) Bacterial Antibiotic	Cancer Infection
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli.

HY-147533

RORγt inverse agonist 30	ROR	Inflammation/Immunology
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC₅₀ of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders.

HY-135880A

OMDM-4

Endogenous Metabolite Neurological Disease

OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM.

HY-135882

OMDM-6	TRP Channel Cannabinoid Receptor Endogenous Metabolite	Neurological Disease
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM.

HY-121557

OMDM-1

Endogenous Metabolite Neurological Disease

OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM.

HY-135881

OMDM-5	TRP Channel Endogenous Metabolite	Neurological Disease
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM).

HY-100821

2,4-Dihydroxyphenylacetylasparagine	Bacterial	Infection
2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes.

HY-135880

OMDM-3

Endogenous Metabolite Neurological Disease

OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM.

HY-W011404

Tributyrin 1 Publications Verification Glyceryl tributyrate	Apoptosis	Metabolic Disease Cancer
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects.

HY-P3528

GPR	Caspase Apoptosis	Neurological Disease
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

HY-103342

OMDM-2

Endogenous Metabolite Neurological Disease

OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM.

HY-N0303

Idebenone 3 Publications Verification	Mitochondrial Metabolism Apoptosis	Neurological Disease
Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC₅₀=16.65 μM). Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Idebenone quickly crosses the blood-brain barrier.

HY-113439

12-HETE	Apoptosis	Inflammation/Immunology Cardiovascular Disease
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway.12-HETE has both anti-thrombotic and pro-thrombotic effects. 12-HETE is a neuromodulator.

HY-112764

DMG-PEG 2000 4 Publications Verification	Liposome	Metabolic Disease
DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.

HY-115450

ONO-0300302	LPL Receptor	Cancer Endocrinology
ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC₅₀ of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with K_d of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research.

HY-10108

LY294002 Maximum Cited Publications 649 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis Autophagy	Cancer Infection
LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator.

HY-W010860

Copper(II) Gluconate	Others	Others
Copper(II) Gluconate is a non-toxic copper supplement aid. Copper(II) Gluconate is the copper salt of D-gluconic acid. Copper(II) Gluconate as a precursor catalyst that can be used in the photo-induced polymerisation of acrylates.

HY-146427

Antifungal agent 29	Fungal	Infection
Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM).

HY-W007390

Methyl 2-amino-5-bromobenzoate	Bacterial	Infection
Methyl 2-amino-5-bromobenzoate (compound 8/12) can be used for synthesis of 2-benzamidobenzoic acids, which are known FabH inhibitors. The derivates also inhibit PqsD, the pqs quorum sensing (QS) system of Pseudomonas aeruginosa, involving the production of a number of virulence factors and biofilm formation.

HY-146123

ATX inhibitor 20

Phosphodiesterase (PDE) Cancer

ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 2.3 nM.

HY-147913

PI3K/Akt/mTOR-IN-3	PI3K Akt mTOR Apoptosis	Cancer
PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC₅₀ values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest.

HY-152251

CB2R/FAAH modulator-1	Cannabinoid Receptor FAAH	Inflammation/Immunology
CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with K_is of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC₅₀ of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production.

HY-100936

Etazolate hydrochloride SQ 20009; EHT 0202 hydrochloride	Phosphodiesterase (PDE) GABA Receptor	Inflammation/Immunology Neurological Disease
Etazolate hydrochloride (SQ 20009) is an orally active, selective inhibitor of type 4 phosphodiesterase (PDE4) with an IC₅₀ of 2 μM. Etazolate hydrochloride is a γ-aminobutyric acid A (GABA_A) receptor regulator. Etazolate hydrochloride is an α-secretase activator and induced the production of soluble amyloid precursor protein (sAPPα). Etazolate hydrochloride, a pyrazolopyridine class derivative, increases cAMP levels. Etazolate hydrochloride has anxiolyticlike, antidepressant-like and anti-inflammatory effects.

HY-B1367

Carbenoxolone disodium	Gap Junction Protein Orthopoxvirus 11β-HSD	Infection Inflammation/Immunology
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.

HY-146282

mGAT-IN-1	GABA Receptor	Neurological Disease
mGAT-IN-1 (compound 28) is a potent and non-selective GAT inhibitor. mGAT-IN-1 has a high inhibitory potency toward mGAT3, with an IC₅₀ of 2.5 μM and pIC₅₀ of 5.61.

HY-103281

Litorin	Bombesin Receptor	Metabolic Disease
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo.

HY-D1445

LysoSensor PDMPO	Fluorescent Dye	Metabolic Disease
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes (Abs=329 nm; Em=440 nm).

HY-155995

PRO-905	Others	Cancer
Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .

HY-W011269

Eicosapentaenoic Acid sodium EPA sodium; Timnodonic acid sodium	Endogenous Metabolite Histone Demethylase	Metabolic Disease Cardiovascular Disease
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation.

HY-B0660

Eicosapentaenoic Acid 5+ Cited Publications EPA; Timnodonic acid	Endogenous Metabolite Histone Demethylase	Neurological Disease Cancer
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation.

HY-B1828

Spectinomycin	Antibiotic Bacterial	Infection
Spectinomycin is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin is also a noncompetitive inhibitor of td intron RNA.

HY-B1828A

Spectinomycin dihydrochloride pentahydrate 2 Publications Verification Spectinomycin hydrochloride hydrate	Bacterial Antibiotic	Infection
Spectinomycin dihydrochloride pentahydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride pentahydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride pentahydrate is also a noncompetitive inhibitor of td intron RNA with an K_i value of 7.2 mM^-.

HY-B0438

Spectinomycin dihydrochloride 2 Publications Verification	Bacterial Antibiotic	Infection
Spectinomycin dihydrochloride is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride is also a noncompetitive inhibitor of td intron RNA with an K_i value of 7.2 mM^-.

HY-10108A

LY294002 hydrochloride	PI3K Casein Kinase DNA-PK Apoptosis	Cancer
LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC₅₀ values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research.

HY-157157

PAD4-IN-3	Protein Arginine Deiminase	Cancer
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment.

HY-16138

Ivaltinostat CG-200745	HDAC MDM-2/p53 Apoptosis	Cancer
Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects.

HY-134539

IMT1 3 Publications Verification	Mitochondrial Metabolism DNA/RNA Synthesis	Cancer Metabolic Disease
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.

HY-16138A

Ivaltinostat formic CG-200745 formic	HDAC MDM-2/p53 Apoptosis	Endocrinology Inflammation/Immunology
Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects.

HY-154857

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine	Others	Cancer
1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures.

HY-18540

KT109	MAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages.

HY-10341

Fasudil Hydrochloride 10+ Cited Publications HA-1077 Hydrochloride; AT-877 Hydrochloride	ROCK Calcium Channel Autophagy PKA PKC HIV	Cancer
Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-10341C

Fasudil dihydrochloride HA-1077 dihydrochloride; AT-877 dihydrochloride	Calcium Channel ROCK PKA PKC Autophagy HIV	Cancer
Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-146281

mGAT3/4-IN-2

GABA Receptor Metabolic Disease Neurological Disease

mGAT3/4-IN-2 (compound 27b) is a potent mGAT3/mGAT4 inhibitor, with pIC₅₀ values of 5.44 and 5.25, respectively.

HY-146280

mGAT3/4-IN-1	GABA Receptor	Metabolic Disease Neurological Disease
mGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC₅₀ values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice.

HY-10341B

Fasudil hydrochloride semihydrate HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrate	ROCK Calcium Channel Autophagy HIV PKA PKC	Cancer
Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-10341A

Fasudil HA-1077; AT877	ROCK Calcium Channel Autophagy PKA PKC	Cancer
Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-149003

PARP1-IN-10	PARP Apoptosis	Cancer
PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC₅₀ value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) .

HY-134988

EDP-305	FXR Phosphatase Cytochrome P450	Inflammation/Immunology
EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC₅₀ values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 shows a potent and consistent antifibrotic effect. EDP-305 can be used for primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH) research.

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Cancer Inflammation/Immunology
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells.

HY-12764

6-OAU 1 Publications Verification GTPL5846	GPR84 ERK Bacterial Antibiotic	Inflammation/Immunology
6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC₅₀ value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function.

HY-N6733

Aphidicolin 2 Publications Verification	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.

HY-W048830

Z-Val-Gly-OH

Amino Acid Derivatives Others

Z-Val-Gly-OH is a N-benzyloxycarbonyl (Z)-dipeptide.
HY-W051418

(R)-2-Amino-2-(4-fluorophenyl)acetic acid

Amino Acid Derivatives Others

(R)-2-Amino-2-(4-fluorophenyl)acetic acid is a Glycine (HY-Y0966) derivative.

HY-W014258

(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid	Amino Acid Derivatives	Others
(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative. (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-137950

Fmoc-Asp(OtBu)-Osu

Amino Acid Derivatives Others

Fmoc-Asp(OtBu)-Osu is an aspartic acid derivative.
HY-W008371

Fmoc-Met-OH

Amino Acid Derivatives Others

Fmoc-Met-OH is a Methionine (HY-13694) derivative.
HY-W017501

2-Amino-3-methylsuccinic acid

Amino Acid Derivatives Others

2-Amino-3-methylsuccinic acid is an aspartic acid derivative.
HY-W005720

H-Phg(4-Cl)-OH

L-4-Chlorophenylglycine
Amino Acid Derivatives Others

H-Phg(4-Cl)-OH (L-4-Chlorophenylglycine) is a Glycine (HY-Y0966) derivative.

HY-W011003

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid	Amino Acid Derivatives	Others
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid is an alanine derivative.

HY-W129448

N-Boc-S-benzyl-D-cysteine

Amino Acid Derivatives Others

N-Boc-S-benzyl-D-cysteine is a cysteine derivative.
HY-W048703

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-tyrosine

Amino Acid Derivatives Others

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-tyrosine is a tyrosine derivative.
HY-W016835

(2S,3S)-2-Acetamido-3-methylpentanoic acid

Amino Acid Derivatives Others

(2S,3S)-2-Acetamido-3-methylpentanoic acid is an isoleucine derivative.
HY-W010959

Fmoc-Asp-OtBu

Amino Acid Derivatives Others

Fmoc-Asp-OtBu is an aspartic acid derivative.
HY-W010830

Fmoc-Lys(Tfa)-OH

Amino Acid Derivatives Others

Fmoc-Lys(Tfa)-OH is a lysine derivative.
HY-Y1844

Fmoc-D-Glu(OtBu)-OH

Amino Acid Derivatives Others

Fmoc-D-Glu(OtBu)-OH is a glutamic acid derivative.
HY-W041996

H-Asp(Obzl)-OtBu.HCl

Amino Acid Derivatives Others

H-Asp(Obzl)-OtBu.HCl is an aspartic acid derivative.
HY-W008787

H-Asp(Oet)-OEt.HCl

Amino Acid Derivatives Others

H-Asp(Oet)-OEt.HCl is an aspartic acid derivative.

HY-79909

L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester	Amino Acid Derivatives	Others
L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester is a phenylalanine derivative.

HY-W089229

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-carbamimidoyl-L-lysine	Amino Acid Derivatives	Others
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-carbamimidoyl-L-lysine is an arginine derivative.

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species	Inflammation/Immunology
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense.

HY-W013874

Boc-D-3-Pal-OH

Amino Acid Derivatives Others

Boc-D-3-Pal-OH is an alanine derivative.
HY-W021299

3-Aminooxolan-2-one hydrobromide

Amino Acid Derivatives Others

3-Aminooxolan-2-one hydrobromide is a serine derivative.
HY-W142113

DL-Aspartic acid potassium salt

Amino Acid Derivatives Others

DL-Aspartic acid potassium salt is an aspartic acid derivative.
HY-W018620

Diphenylmethylene-glycine benzyl ester

Amino Acid Derivatives Others

Diphenylmethylene-glycine benzyl ester is a Glycine (HY-Y0966) derivative.
HY-Y0555

N-[(Phenylmethoxy)carbonyl]-L-leucine

Amino Acid Derivatives Others

N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative.

HY-79930

D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, phenylmethyl ester	Amino Acid Derivatives	Others
D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, phenylmethyl ester is a phenylalanine derivative.

HY-W009117

Dimethyl 3,3'-disulfanediyl(2R,2'R)-bis(2-aminopropanoate) dihydrochloride	Amino Acid Derivatives	Others
Dimethyl 3,3'-disulfanediyl(2R,2'R)-bis(2-aminopropanoate) dihydrochloride is a cysteine derivative.

HY-W030573

((4'-Chloro-[1,1'-biphenyl]-4-yl)sulfonyl)phenylalanine

Amino Acid Derivatives Others

((4'-Chloro-[1,1'-biphenyl]-4-yl)sulfonyl)phenylalanine is a phenylalanine derivative.
HY-42709

Z-Val-Ala-OH

Carbobenzoxy-L-valyl-L-alanine
Amino Acid Derivatives Others

Z-Val-Ala-OH is a dipeptide derivative of valine and alanine.
HY-W028991

N-(4-Nitrobenzoyl)glycine

Amino Acid Derivatives Others

N-(4-Nitrobenzoyl)glycine is a Glycine (HY-Y0966) derivative.
HY-W011722

N-((Benzyloxy)carbonyl)-N-methyl-L-valine

Amino Acid Derivatives Others

N-((Benzyloxy)carbonyl)-N-methyl-L-valine is a valine derivative.

HY-20153

Ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-methylacetamido)acetate	Amino Acid Derivatives	Others
Ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-methylacetamido)acetate is a Glycine (HY-Y0966) derivative.

HY-W141942

4-Fluoro-DL-glutamic acid

Amino Acid Derivatives Others

4-Fluoro-DL-glutamic acid is a glutamic acid derivative.

HY-W008667

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate	Amino Acid Derivatives	Others
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate is a glutamic acid derivative.

HY-75332

Z-D-Phg-OH D-Cbz phenylglycine	Amino Acid Derivatives	Others
Z-D-Phg-OH (D-Cbz phenylglycine) is a N-blocked amino acids with K_d values of 390 μM and 323 μM for tBuCQN and tBuCQD, respectively.

HY-W007573

(S)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid	Amino Acid Derivatives	Others
(S)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid is an aspartic acid derivative.

HY-W013968

Boc-Gly-Gly-OH

Amino Acid Derivatives Others

Boc-Gly-Gly-OH is a Glycine (HY-Y0966) derivative.
HY-W107585

β-Glutamic acid

3-Aminopentanedioic acid
Amino Acid Derivatives Others

β-Glutamic acid (3-Aminopentanedioic acid) is aβ amino acid.
HY-W012713

Ac-D-Ala-OH

Amino Acid Derivatives Others

Ac-D-Ala-OH is an alanine derivative.
HY-W011200

H-Gly-OBzl.TosOH

Amino Acid Derivatives Others

H-Gly-OBzl.TosOH is a Glycine (HY-Y0966) derivative.

HY-W065053

trans-N-Methyl-4-methoxyproline	Amino Acid Derivatives	Others
trans-N-Methyl-4-methoxyproline is a natural product that can be isolated from the stems of Petiveria alliacea and is also a Proline derivative.

HY-W013659

Fmoc-Asp(OcHex)-OH

Amino Acid Derivatives Others

Fmoc-Asp(OcHex)-OH is an aspartic acid derivative.
HY-W007842

Z-Ser-OH

Amino Acid Derivatives Others

Z-Ser-OH is a serine derivative.

HY-W009392

(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid	Amino Acid Derivatives	Others
(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid is a leucine derivative.

HY-W041983

Fmoc-Cpa-OH

Amino Acid Derivatives Others

Fmoc-Cpa-OH is a compound containing both an amino group and a carboxyl group.
HY-W142081

N-(2,4-Dinitrophenyl)-L-serine

Amino Acid Derivatives Others

N-(2,4-Dinitrophenyl)-L-serine is a serine derivative.
HY-78733

N-Fmoc-L-valine N-succinimidyl ester

Amino Acid Derivatives Others

N-Fmoc-L-valine N-succinimidyl ester is a valine derivative.
HY-W068839

L-Phenylalanyl-L-leucine

Amino Acid Derivatives Others

L-Phenylalanyl-L-leucine is a leucine derivative.
HY-W008016

Fmoc-Tyr(tBu)-OH

Amino Acid Derivatives Others

Fmoc-Tyr(tBu)-OH is a tyrosine derivative.
HY-60256

(R)-Pyrrolidine-3-carboxylic acid

Amino Acid Derivatives Others

(R)-Pyrrolidine-3-carboxylic acid is a proline derivative.
HY-W019676

Boc-Tyr-OtBu

Amino Acid Derivatives Others

Boc-Tyr-OtBu is a tyrosine derivative.

HY-W011001

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid	Amino Acid Derivatives	Others
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid is an alanine derivative.

HY-22062

Fmoc-Chg-OH

Cyclohexaneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (S)-
Amino Acid Derivatives Others

Fmoc-Chg-OH is a Glycine (HY-Y0966) derivative.
HY-W003225

3-Bromo-DL-phenylalanine

Amino Acid Derivatives Others

3-Bromo-DL-phenylalanine is a phenylalanine derivative.
HY-W010793

Fmoc-Bpa-OH

Amino Acid Derivatives Others

Fmoc-Bpa-OH is a phenylalanine derivative.
HY-W009005

Fmoc-HoPhe-OH

Amino Acid Derivatives Others

Fmoc-HoPhe-OH is a phenylalanine derivative.
HY-W008021

Fmoc-D-Leu-OH

Amino Acid Derivatives Others

Fmoc-D-Leu-OH is a leucine derivative.
HY-W014418

H-D-Val-OtBu.HCl

Amino Acid Derivatives Others

H-D-Val-OtBu.HCl is a valine derivative.
HY-118349

Dansylphenylalanine

Amino Acid Derivatives Others

Dansylphenylalanine is a phenylalanine derivative.

HY-W011324

(S)-2-((tert-Butoxycarbonyl)amino)-4-(cyclohexyloxy)-4-oxobutanoic acid	Amino Acid Derivatives	Others
(S)-2-((tert-Butoxycarbonyl)amino)-4-(cyclohexyloxy)-4-oxobutanoic acid is an aspartic acid derivative.

HY-W013824

Boc-D-Phe(3,4-DiF)-OH

Amino Acid Derivatives Others

Boc-D-Phe(3,4-DiF)-OH is a phenylalanine derivative.
HY-20861

(R)-2-amino-3-cyclobutylpropanoic acid

Amino Acid Derivatives Others

(R)-2-amino-3-cyclobutylpropanoic acid is an alanine derivative.

HY-34597

(S)-2-Amino-3-(4-bromophenyl)propanoic acid (S)-p-Bromophenylalanine; L-4-Bromophenylalanine; L-p-Bromophenylalanine; p-Bromo-L-phenylalanine	Amino Acid Derivatives	Others
(S)-2-Amino-3-(4-bromophenyl)propanoic acid is a phenylalanine derivative.

HY-W008233

Z-Asn-OH

Amino Acid Derivatives Others

Z-Asn-OH is an asparagine derivative.
HY-W008688

Fmoc-L-Norleucine

Amino Acid Derivatives Others

Fmoc-L-Norleucine is a leucine derivative.
HY-W052310

Methyl ((benzyloxy)carbonyl)-D-serinate

Amino Acid Derivatives Others

Methyl ((benzyloxy)carbonyl)-D-serinate is a serine derivative.
HY-42065

Boc-Asp-OH

Amino Acid Derivatives Others

Boc-Asp-OH is an aspartic acid derivative.
HY-W008696

Fmoc-Thr-OH

Amino Acid Derivatives Others

Fmoc-Thr-OH is a threonine derivative.
HY-W048701

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-histidine

Amino Acid Derivatives Others

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-histidine is a histidine derivative.
HY-W040416

(S)-2-(((Benzyloxy)carbonyl)amino)pent-4-enoic acid

Amino Acid Derivatives Others

(S)-2-(((Benzyloxy)carbonyl)amino)pent-4-enoic acid is a Glycine (HY-Y0966) derivative.
HY-W009913

2-((Carboxymethyl)amino)benzoic acid

Amino Acid Derivatives Others

2-((Carboxymethyl)amino)benzoic acid is a Glycine (HY-Y0966) derivative.

HY-W091734

Methyl 4-iodo-L-phenylalaninate hydrochloride	Amino Acid Derivatives	Neurological Disease Cardiovascular Disease
Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease.

HY-W011002

Fmoc-3-Ala(2-thienyl)-OH

Amino Acid Derivatives Others

Fmoc-3-Ala(2-thienyl)-OH is an alanine derivative.
HY-W004098

Boc-D-Met-OH

Amino Acid Derivatives Others

Boc-D-Met-OH is a Methionine (HY-13694) derivative.
HY-W141791

S-tert-Butylmercapto-L-cysteine

Amino Acid Derivatives Others

S-tert-Butylmercapto-L-cysteine is a cysteine derivative.
HY-W009381

H-Tyr(Bzl)-OH

Amino Acid Derivatives Others

H-Tyr(Bzl)-OH is a tyrosine derivative.
HY-W009003

Fmoc-Tyr-OH

Amino Acid Derivatives Others

Fmoc-Tyr-OH is a tyrosine derivative.
HY-W008958

Fmoc-MeSer(Bzl)-OH

Amino Acid Derivatives Others

Fmoc-MeSer(Bzl)-OH is a serine derivative.
HY-W105804

Selenocystamine dihydrochloride

Amino Acid Derivatives Others

Selenocystamine (dihydrochloride) is aselenocysteine derivatives.
HY-W010873

Z-Pro-Leu-Gly-OEt

Amino Acid Derivatives Others

Z-Pro-Leu-Gly-OEt is a tripeptide.
HY-W008254

H-Ser-NH2.HCl

Amino Acid Derivatives Others

H-Ser-NH2.HCl is a serine derivative.
HY-W002326

Boc-Asp(OtBu)-OH

Amino Acid Derivatives Others

Boc-Asp(OtBu)-OH is an aspartic acid derivative.
HY-W008353

H-1-Nal-OH

Amino Acid Derivatives Others

H-1-Nal-OH is an alanine derivative.
HY-W013734

N,N'-Di-BOC-L-cystine

Amino Acid Derivatives Others

N,N'-Di-BOC-L-cystine is a cysteine derivative.
HY-W050025

6-Chloro-L-tryptophan

Amino Acid Derivatives Others

6-Chloro-L-tryptophan is a Tryptophan derivative. 6-Chloro-L-tryptophan can be used as a substrate for KtzQ.
HY-W141911

Gly-Asp

Amino Acid Derivatives Others

Gly-Asp is a Glycine (HY-Y0966) derivative.

HY-W011322

(R)-2-((tert-Butoxycarbonyl)amino)-3-(naphthalen-1-yl)propanoic acid	Amino Acid Derivatives	Others
(R)-2-((tert-Butoxycarbonyl)amino)-3-(naphthalen-1-yl)propanoic acid is an alanine derivative.

HY-W040686

2-(Bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid

Amino Acid Derivatives Others

2-(Bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid is a Glycine (HY-Y0966) derivative.

HY-N2378

(2R,3S)-3-Phenylisoserine hydrochloride Benzenepropanoic acid, β-amino-α-hydroxy-, hydrochloride, (αR,βS)-	Amino Acid Derivatives	Others
(2R,3S)-3-Phenylisoserine hydrochloride is a serine derivative.

HY-W013297

Z-D-Lys-OH

Amino Acid Derivatives Others

Z-D-Lys-OH is a lysine derivative.

HY-119782

L-Argininamide	Fluorescent Dye	Others
L-Argininamide is a hydrophilic amino acid derivative and can be used as a compound for ligand binding DNA aptamers. L-Argininamide has the potential for fluorescent aptasensors development.

HY-W010734

Fmoc-Ser(Trt)-OH

Amino Acid Derivatives Others

Fmoc-Ser(Trt)-OH is a serine derivative.
HY-W013406

H-D-Tyr-OEt.HCl

Amino Acid Derivatives Others

H-D-Tyr-OEt.HCl is a tyrosine derivative.
HY-W053531

H-Hyp(tBu)-OH

Amino Acid Derivatives Others

H-Hyp(tBu)-OH is a proline derivative.
HY-W013155

H-His(Trt)-OH

Amino Acid Derivatives Others

H-His(Trt)-OH is a histidine derivative.
HY-W024554

AC-Asp(OtBU)-OH

Amino Acid Derivatives Others

AC-Asp(OtBU)-OH is an aspartic acid derivative.
HY-W019205

(4S)-1-Boc-4-amino-D-proline

Amino Acid Derivatives Others

(4S)-1-Boc-4-amino-D-proline is an amino acid derivative that can be used for compound synthesis.
HY-20561A

N-Methyl-D-valine

Amino Acid Derivatives Others

N-Methyl-D-valine is a valine derivative.
HY-W013793

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-serine

Amino Acid Derivatives Others

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-serine is a serine derivative.

HY-I0102

(2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate	Amino Acid Derivatives	Others
(2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate is a valine derivative.

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).

HY-W012075

H-Cys(pMeOBzl)-OH

Amino Acid Derivatives Others

H-Cys(pMeOBzl)-OH is a cysteine derivative.
HY-77802

(2R,2'R)-4,4'-Disulfanediylbis(2-aminobutanoic acid)

Amino Acid Derivatives Others

(2R,2'R)-4,4'-Disulfanediylbis(2-aminobutanoic acid) is a cysteine derivative.
HY-W010825<

acid

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products