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Cat. No.: HY-P2682

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MMP-8 Fluorogenic substrate

MMP-8 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a fluorescent peptide substrate used for the catalytic activity of MMP-8. MMP-8 Fluorogenic substrate is hydrolyzed by MMP-8 , thereby relieving the quenching of the Trp fluorophore by DNP and enabling continuous fluorescence assays.

For research use only. We do not sell to patients.

CAS No.: 135662-05-4
Formula: C₄₉H₆₃N₁₃O₁₃
Molecular Weight:1042.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MMP-8 Fluorogenic substrate Chemical Structure

CAS No.: 135662-05-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[2]

MMP-8

All MMP Isoforms :

In Vitro

Innate ImmunityProtein/Amino Acid Metabolism

Innate Immunity

MMP-8 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) (submicromolar enzyme concentration; less than 10 min) is a fluorescent HNC/MMP-8 substrate, k_cat = 11,000 h⁻¹, K_M = 7.7 μM^[2].

Protein/Amino Acid Metabolism

MMP-8 Fluorogenic substrate (20 µM; pre-incubated for 10 min before adding the substrate) is used as a fluorogenic substrate to monitor activated human MMP-8 activity in cell-free assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 135662-05-4
Molecular Weight 1042.10
Formula C₄₉H₆₃N₁₃O₁₃
Sequence

{DNP}-Pro-Leu-Ala-Tyr-Trp-Ala-Arg
Sequence Shortening

{DNP}-PLAYWAR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Morla S, et al. Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8. Biomolecules. 2020 Aug 09;10(8):1166. [Content Brief]

[2]. Schwartz MA, et al. Synthetic inhibitors of bacterial and mammalian interstitial collagenases. Prog Med Chem. 1992;29:271-334.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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