2. Apoptosis
  3. Caspase Apoptosis
  4. GPR

GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

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GPR Chemical Structure

GPR Chemical Structure

CAS No. : 47295-77-2

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GPR Related Antibodies

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Description

GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

In Vitro

GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1].
GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1].
GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1].
GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPR Related Antibodies

Apoptosis Analysis[1]

Cell Line: p53-positive cells
Concentration: 50 μM
Incubation Time: 3 days
Result: Inhibited Ah-induced increase in numbers of p53-positive neurons.
Clinical Trial
Molecular Weight

328.37

Formula

C13H24N6O4
CAS No.
Sequence Shortening

GPR
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GPR Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR47295-77-2CaspaseApoptosisAmyloid β-peptide (Aβ)Alzheimer’s disease (AD)Gly-Pro-Arg (GPR)three amino acid peptidecaspase-3/p53apoptosisInhibitorinhibitorinhibit

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