GPR
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).
For research use only. We do not sell to patients.
- CAS No.: 47295-77-2
- Formula: C13H24N6O4
- Molecular Weight:328.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
In Vitro
GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1].
GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1].
GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1].
GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:p53-positive cells
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Concentration:50 μM
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Incubation Time:3 days
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Result:Inhibited Ah-induced increase in numbers of p53-positive neurons.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 47295-77-2
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Molecular Weight 328.37
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Formula C13H24N6O4
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Sequence Shortening
GPR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPR Related Classifications
HY-P3528 Related Classifications
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