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SR 11302 

Cat. No.: HY-15870
Handling Instructions

SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).

For research use only. We do not sell to patients.

SR 11302 Chemical Structure

SR 11302 Chemical Structure

CAS No. : 160162-42-5

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Description

SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE)[1].

IC50 & Target

AP-1[1]

In Vitro

SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα[1].
SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells[2].
SR 11302 (SR-11302; 2 µM; 48 hours) inhibits Helicobacter pylori (H. pylori)-induced cell proliferation in adenocarcinoma gastric (AGS) cells[3].
SR 11302 (2 µM; 24 hours) inhibits H. pylori-induced expression of β-catenin and c-myc in AGS cells[3].

In Vivo

SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr-/- mice in a dose-dependent manner[4].

Animal Model: Vldlr-/- mice[4]
Dosage: Low dose 0.5 mg/kg and high dose 1 mg/kg body weight
Administration: Orally gavaged daily from P5 to P15
Result: High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight.
Molecular Weight

376.53

Formula

C₂₆H₃₂O₂

CAS No.

160162-42-5

SMILES

O=C(O)/C=C(C)/C=C/C=C(C1=CC=C(C)C=C1)/C=C/C2=C(C)CCCC2(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SR 11302SR11302SR-11302Othersactivatorprotein-1AP-1retinoicacidresponseelementRARELungCancerretinoidInhibitorinhibitorinhibit

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