SR 11302
Based on 25 publication(s) in Google Scholar
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 160162-42-5
- Formula: C26H32O2
- Molecular Weight:376.53
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Storage:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SR 11302
More- Nature. 2026 Jan;649(8098):1013-1021. [Abstract]
- Nature. 2025 Jan;637(8045):402-411. [Abstract]
- Cell Res. 2026 Jan 9. [Abstract]
- Cell Mol Immunol. 2022 Jul;19(7):805-819. [Abstract]
- Environ Health Perspect. 2025 Apr 9. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2426714122. [Abstract]
- Dev Cell. 2026 Jan 12:S1534-5807(25)00768-3. [Abstract]
- Dev Cell. 2025 Mar 24;60(6):819-836.e7. [Abstract]
- Phytomedicine. 2025 Dec 26:150:157744. [Abstract]
- Cell Rep. 2023 Dec 1;42(12):113504. [Abstract]
- J Agric Food Chem. 2022 Feb 16;70(6):1996-2009. [Abstract]
- Life Sci. 2026 Mar 1:388:124173. [Abstract]
- Mediators Inflamm. 2025 Oct 10:2025:1240226. [Abstract]
- iScience. 2026 Apr 1;29(5):115396. [Abstract]
- J Inflamm Res. 2025 Jun 19:18:8033-8048. [Abstract]
- iScience. 2025 Jan 6;28(2):111708. [Abstract]
- Viruses. 2022 Jul 7;14(7):1485. [Abstract]
- Cardiovasc Drugs Ther. 2025 May 22. [Abstract]
- Vet Microbiol. 2021 May:256:109061. [Abstract]
- Npj Viruses. 2025 Sep 18;3(1):69. [Abstract]
- Indiana University. 2025.
- Columbia University. 2025.
- SSRN. 2025 Jan 10.
- Preprint. 2025 Jan 07.
- bioRxiv. 2024 Nov 4:2024.10.08.617155. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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Cell Imaging/Staining
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Flow Cytometry
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WB
All AP-1 Isoforms
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Biological Activity
AP-1[1]
SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα[1].
SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells[2].
SR 11302 (SR-11302; 2 μM; 48 hours) inhibits Helicobacter pylori (H. pylori)-induced cell proliferation in adenocarcinoma gastric (AGS) cells[3].
SR 11302 (2 μM; 24 hours) inhibits H. pylori-induced expression of β-catenin and c-myc in AGS cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Vldlr-/- mice[4]
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Dosage:Low dose 0.5 mg/kg and high dose 1 mg/kg body weight
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Administration:Orally gavaged daily from P5 to P15
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Result:High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight.
Chemical Information
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CAS No. 160162-42-5
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Appearance Solid
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Molecular Weight 376.53
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Formula C26H32O2
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Color Light yellow to yellow
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SMILES
O=C(O)/C=C(C)/C=C/C=C(C1=CC=C(C)C=C1)/C=C/C2=C(C)CCCC2(C)C
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Publications (25)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jan;649(8098):1013-1021. PMID: 41372410
SR 11302 purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8098):1013-1021. [Abstract]
Cell viability of MCF7 and T47D cells treated with tamoxifen and increased concentrations of AP-1 inhibitor SR11302 (1-20 μM), alone or in combination. Data are from three biological replicates and are presented as mean ± SD. P-values represents Kruskal-Wallis followed by Dunn post-hoc correction.
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Nature
2025 Jan;637(8045):402-411. PMID: 39633051
SR 11302 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jan;637(8045):402-411. [Abstract]
Western blots (top) and signal intensity (bottom) of BLM in E12.5 fetal liver Lin– HSPCs cultured with or without FetuA and the bZIP inhibitor SR11302 (2 mM, 6 h).
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Cell Res
Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells. [Abstract]2026 Jan 9. PMID: 41507440 -
Cell Mol Immunol
The kinase p38α functions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation. [Abstract]2022 Jul;19(7):805-819. PMID: 35551270 -
Environ Health Perspect
2025 Apr 9. PMID: 40203079
SR 11302 purchased from MedChemExpress. Usage Cited in: Environ Health Perspect. 2025 Apr 9. [Abstract]
WB of ATF3 and JunB in AML12 cells after SR11302 (2 μM, 24 h) treatment.
SR 11302 purchased from MedChemExpress. Usage Cited in: Environ Health Perspect. 2025 Apr 9. [Abstract]
Nile Red staining of AML12 cells in the control, BPS (100 μM), and BPS+SR11302 (2 μM, 24 h) group.
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Proc Natl Acad Sci U S A
Jund orchestrates cis-regulatory element dynamics to facilitate endothelial-to-hematopoietic transition. [Abstract]2025 Jun 10;122(23):e2426714122. PMID: 40472028 -
Dev Cell
MITA/STING-driven CD38 induction in Siglec-Flow macrophages promotes regulatory T cell survival and non-small cell lung cancer progression. [Abstract]2026 Jan 12:S1534-5807(25)00768-3. PMID: 41529690 -
Dev Cell
Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate. [Abstract]2025 Mar 24;60(6):819-836.e7. PMID: 39667932 -
Phytomedicine
Jinlida ameliorates diabetic kidney disease via gut microbiota-dependent production of pyridoxamine targeting renal AGEs/RAGE and TGF-β pathways. [Abstract]2025 Dec 26:150:157744. PMID: 41485293 -
Cell Rep
Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner. [Abstract]2023 Dec 1;42(12):113504. PMID: 38041811 -
J Agric Food Chem
Glycyrrhizic Acid against Mycoplasma gallisepticum-Induced Inflammation and Apoptosis Through Suppressing the MAPK Pathway in Chickens. [Abstract]2022 Feb 16;70(6):1996-2009. PMID: 35128924 -
Life Sci
Galectin-9 in human trophoblast cells: Implications for maternal-fetal immune balance and pregnancy complications. [Abstract]2026 Mar 1:388:124173. PMID: 41544754 -
Mediators Inflamm
Integrative Bulk and Single-Cell Transcriptomic Profiling Reveals Oxidative Stress-Related Genes and Potential Therapeutic Targets in Osteoarthritis. [Abstract]2025 Oct 10:2025:1240226. PMID: 41111909
SR 11302 purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Oct 10:2025:1240226. [Abstract]
Annexin V/7-AAD flow cytometry showing that si-FOS, SR11302 (5 μM, 24 h), or UA treatment reduced IL-1β-induced apoptosis compared with IL-1β + si-NC.
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iScience
Mechanical activation of PIEZO1 drives AP-1-dependent PTGS2/PGE2 signaling and corneal inflammation. [Abstract]2026 Apr 1;29(5):115396. PMID: 42023150 -
J Inflamm Res
Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury. [Abstract]2025 Jun 19:18:8033-8048. PMID: 40551988 -
iScience
Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape. [Abstract]2025 Jan 6;28(2):111708. PMID: 39898054 -
Viruses
Inducible miR-150 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Genome and Suppressor of Cytokine Signaling 1. [Abstract]2022 Jul 7;14(7):1485. PMID: 35891465 -
Cardiovasc Drugs Ther
Midkine Promote Atherosclerosis by Regulating the Expression of ATP-Binding Cassette Transporter A1 via Activator Protein-1. [Abstract]2025 May 22. PMID: 40402391 -
Vet Microbiol
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) induces IL-6 production through TAK-1/JNK/AP-1 and TAK-1/NF-κB signaling pathways. [Abstract]2021 May:256:109061. PMID: 33836390 -
Npj Viruses
2025 Sep 18;3(1):69. PMID: 40968155 -
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bioRxiv
2024 Nov 4:2024.10.08.617155. PMID: 39415993
Solvent & Solubility
DMSO : 33.33 mg/mL (88.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. C Huang, et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30. [Content Brief]
[2]. Bradley A Maron, et al. Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation. 2014 Jul 8;130(2):168-79. [Content Brief]
[3]. Eunyoung Byun, et al. Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells. Yonsei Med J. 2016 May;57(3):647-51. [Content Brief]
[4]. Ye Sun, et al. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 Jun 5;214(6):1753-1767. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.6558 mL | 13.2792 mL | 26.5583 mL | 66.3958 mL |
| 5 mM | 0.5312 mL | 2.6558 mL | 5.3117 mL | 13.2792 mL | |
| 10 mM | 0.2656 mL | 1.3279 mL | 2.6558 mL | 6.6396 mL | |
| 15 mM | 0.1771 mL | 0.8853 mL | 1.7706 mL | 4.4264 mL | |
| 20 mM | 0.1328 mL | 0.6640 mL | 1.3279 mL | 3.3198 mL | |
| 25 mM | 0.1062 mL | 0.5312 mL | 1.0623 mL | 2.6558 mL | |
| 30 mM | 0.0885 mL | 0.4426 mL | 0.8853 mL | 2.2132 mL | |
| 40 mM | 0.0664 mL | 0.3320 mL | 0.6640 mL | 1.6599 mL | |
| 50 mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.3279 mL | |
| 60 mM | 0.0443 mL | 0.2213 mL | 0.4426 mL | 1.1066 mL | |
| 80 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8299 mL |
SR 11302 Related Classifications
HY-15870 Related Classifications
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