2. Signaling Pathways
  3. Immunology/Inflammation
  4. AP-1
  5. FosB Isoform

FosB

FosB is a member of the Activator Protein-1 (AP-1) transcription factor family that regulates gene expression in response to extracellular stimuli[1][2]. Mechanistically, FosB integrates signals from pathways including P2RX7 nucleotide receptor activation, TGF-β signaling, and IL-1-mediated inflammatory pathways, modulating cellular proliferation, differentiation, migration, and osteogenic or immune responses[1][3]. In disease models, FosB isoforms such as ΔFosB exhibit region-specific effects in the brain, influencing reward circuitry, stress response, and cognitive function in addiction, depression, and Parkinson’s disease[4][5][6]. Compared with related Fos isoforms, ΔFosB demonstrates enhanced nuclear stability and prolonged transcriptional activity, which allows sustained regulation of target genes including GluA2, parkin, and COX-2[4][5][1]. FosB also forms heterodimeric complexes with other transcription factors such as NFATc3 to regulate tissue factor expression and monocyte trafficking in inflammatory models[7]. Functionally, pharmacological or genetic manipulation of FosB or ΔFosB alters migration, invasion, and fibrosis-related pathways, highlighting their utility as targets in neurodegeneration and cancer research[8][3]. Isoform-specific transcriptional activity and inducibility make FosB a critical node in linking extracellular signals to downstream gene networks, offering mechanistic insight for experimental designs involving transcriptional regulation, stress response, and tissue-specific pathology[1][2].

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FosB Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-W471288
    JPC0661
    		Inhibitor
    JPC0661 is a direct and allosteric ΔFOSB inhibitor. JPC0661 inhibits the binding of ΔFOSB/JUND and ΔFOsB to DNA with IC50 values in the micromolar range (9-52 uM), directly inhibits ΔFOSB-mediated transcription with IC50 of 0.82 μM in vitro. JPC0661 significantly reduces ΔFOSB occupancy at genomic AP1 sites in vivo. JPC0661 binds to a novel groove outside the DNA-binding cleft of ΔFOSB and disrupt the formation of the ΔFOSB/JUND-DNA complex. JPC0661 can be used for Alzheimer's disease research.
  • HY-170916
    Angiogenesis inhibitor 7
    Angiogenesis inhibitor 7 (compound BT2) ia a potent inhibitor of angiogenesis. Angiogenesis inhibitor 7 inhibits ERK phosphorylation, FosB/ΔFosB and VCAM-1 expression.
  • HY-179594
    HTS10307
    		Inhibitor
    HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease.