2. Immunology/Inflammation
  3. AP-1
  4. HTS10307

HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease.

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HTS10307

HTS10307 Chemical Structure

CAS No. : 81682-91-9

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HTS10307 Related Antibodies

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c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

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Description

HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease[1].

IC50 & Target[1]

FosB

 

Molecular Weight

268.29

Formula

C14H8N2O2S
CAS No.
SMILES

O=C(N1)C(C#N)=C(C2=CC=CO2)C=C1C3=CC=CS3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HTS10307 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HTS1030781682-91-9HTS 10307HTS-10307AP-1Activator Protein 1AP1 Transcription Factordrug addictionAlzheimer’s diseaseParkinson’s diseaseInhibitorinhibitorinhibit

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