30479-81-3
Chemical Structure
JPC0661
- CAS No.: 30479-81-3
- Formula:C15H13N3O5S
- Molecular Weight:347.35
IUPAC Name: 4-(1-methyl-1H-imidazol-2-yl)azepan-4-ol
InChIKey: ZZSAILZSWKPTCT-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC(S(=O)(O)=O)=C(OC3=CC=CC=C3)C=C2)N=C(N)C1
Biological Activity:
JPC0661 is a direct and allosteric ΔFOSB inhibitor. JPC0661 inhibits the binding of ΔFOSB/JUND and ΔFOsB to DNA with IC50 values in the micromolar range (9-52 uM), directly inhibits ΔFOSB-mediated transcription with IC50 of 0.82 μM in vitro. JPC0661 significantly reduces ΔFOSB occupancy at genomic AP1 sites in vivo. JPC0661 binds to a novel groove outside the DNA-binding cleft of ΔFOSB and disrupt the formation of the ΔFOSB/JUND-DNA complex. JPC0661 can be used for Alzheimer's disease research[1].
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JPC0661 | JPC0661 is a direct and allosteric ΔFOSB inhibitor. JPC0661 inhibits the binding of ΔFOSB/JUND and ΔFOsB to DNA with IC50 values in the micromolar range (9-52 uM), directly inhibits ΔFOSB-mediated transcription with IC50 of 0.82 μM in vitro. JPC0661 significantly reduces ΔFOSB occupancy at genomic AP1 sites in vivo. JPC0661 binds to a novel groove outside the DNA-binding cleft of ΔFOSB and disrupt the formation of the ΔFOSB/JUND-DNA complex. JPC0661 can be used for Alzheimer's disease research. |
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Keywords
