2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. TUG-469

TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.

For research use only. We do not sell to patients.

TUG-469 Chemical Structure

TUG-469 Chemical Structure

CAS No. : 1236109-67-3

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Based on 1 publication(s) in Google Scholar

TUG-469 Related Antibodies

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Description

TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2].

In Vitro

TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC50 value of 7.73[1].
TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation[1].
TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively[2].
TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TUG-469 Related Antibodies
In Vivo

TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NZO mice with glucose administration[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration
Result: Reduced the blood glucose level.
Molecular Weight

345.43

Formula

C23H23NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC1=CC=C(C=C1)NCC2=CC(C3=CC=CC=C3C)=CC=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8949 mL 14.4747 mL 28.9494 mL
5 mM 0.5790 mL 2.8949 mL 5.7899 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8949 mL 14.4747 mL 28.9494 mL 72.3736 mL
5 mM 0.5790 mL 2.8949 mL 5.7899 mL 14.4747 mL
10 mM 0.2895 mL 1.4475 mL 2.8949 mL 7.2374 mL
15 mM 0.1930 mL 0.9650 mL 1.9300 mL 4.8249 mL
20 mM 0.1447 mL 0.7237 mL 1.4475 mL 3.6187 mL
25 mM 0.1158 mL 0.5790 mL 1.1580 mL 2.8949 mL
30 mM 0.0965 mL 0.4825 mL 0.9650 mL 2.4125 mL
40 mM 0.0724 mL 0.3619 mL 0.7237 mL 1.8093 mL
50 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4475 mL
60 mM 0.0482 mL 0.2412 mL 0.4825 mL 1.2062 mL
80 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9047 mL
100 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
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TUG-469 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TUG-4691236109-67-3TUG469TUG 469Free Fatty Acid ReceptorFFARdiabetesGPR40fatty acidsdrug discoveryglucose tolerancemiceInhibitorinhibitorinhibit

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