1. Metabolic Enzyme/Protease
  2. Epoxide Hydrolase
  3. 1-Cyclohexyl-3-dodecyl urea

1-Cyclohexyl-3-dodecyl urea (Synonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND)

Cat. No.: HY-135795 Purity: >98.0%
Handling Instructions

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.

For research use only. We do not sell to patients.

1-Cyclohexyl-3-dodecyl urea Chemical Structure

1-Cyclohexyl-3-dodecyl urea Chemical Structure

CAS No. : 402939-18-8

Size Price Stock Quantity
10 mM * 1 mL in Ethanol USD 72 In-stock
Estimated Time of Arrival: December 31
5 mg USD 65 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 330 In-stock
Estimated Time of Arrival: December 31
100 mg USD 560 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].

IC50 & Target

IC50: soluble epoxide hydrolase (sEH)[1]

In Vivo

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals[1].

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3mg/day
Administration: Intraperitoneal injection; 4 days
Result: Had antihypertensive properties.
Clinical Trial
Molecular Weight

310.52

Formula

C₁₉H₃₈N₂O

CAS No.

402939-18-8

SMILES

O=C(NCCCCCCCCCCCC)NC1CCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 16.67 mg/mL (53.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2204 mL 16.1020 mL 32.2040 mL
5 mM 0.6441 mL 3.2204 mL 6.4408 mL
10 mM 0.3220 mL 1.6102 mL 3.2204 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 1.67 mg/mL (5.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

1-Cyclohexyl-3-dodecyl ureaCDUN-Cyclohexyl-N-dodecyl ureaNCNDEpoxide HydrolaseepoxyeicosatrienoicacidbloodpressureEETantihypertensiveInhibitorinhibitorinhibit

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Product Name:
1-Cyclohexyl-3-dodecyl urea
Cat. No.:
HY-135795
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