2. Metabolic Enzyme/Protease
  3. Epoxide Hydrolase
  4. 1-Cyclohexyl-3-dodecyl urea

1-Cyclohexyl-3-dodecyl urea  (Synonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND)

Cat. No.: HY-135795 Purity: ≥98.0%
COA Handling Instructions

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1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.

For research use only. We do not sell to patients.

1-Cyclohexyl-3-dodecyl urea Chemical Structure

1-Cyclohexyl-3-dodecyl urea Chemical Structure

CAS No. : 402939-18-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in Ethanol USD 71 In-stock
Solid
1 mg USD 30 In-stock
5 mg USD 65 In-stock
10 mg USD 110 In-stock
50 mg USD 330 In-stock
100 mg USD 560 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

1-Cyclohexyl-3-dodecyl urea Related Antibodies

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Description

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].

IC50 & Target

IC50: soluble epoxide hydrolase (sEH)[1]
In Vivo

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3mg/day
Administration: Intraperitoneal injection; 4 days
Result: Had antihypertensive properties.
Clinical Trial
Molecular Weight

310.52

Formula

C19H38N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCCCCCCCCCC)NC1CCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 16.67 mg/mL (53.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2204 mL 16.1020 mL 32.2040 mL
5 mM 0.6441 mL 3.2204 mL 6.4408 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 1.67 mg/mL (5.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.2204 mL 16.1020 mL 32.2040 mL 80.5101 mL
5 mM 0.6441 mL 3.2204 mL 6.4408 mL 16.1020 mL
10 mM 0.3220 mL 1.6102 mL 3.2204 mL 8.0510 mL
15 mM 0.2147 mL 1.0735 mL 2.1469 mL 5.3673 mL
20 mM 0.1610 mL 0.8051 mL 1.6102 mL 4.0255 mL
25 mM 0.1288 mL 0.6441 mL 1.2882 mL 3.2204 mL
30 mM 0.1073 mL 0.5367 mL 1.0735 mL 2.6837 mL
40 mM 0.0805 mL 0.4026 mL 0.8051 mL 2.0128 mL
50 mM 0.0644 mL 0.3220 mL 0.6441 mL 1.6102 mL
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1-Cyclohexyl-3-dodecyl urea Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Cyclohexyl-3-dodecyl urea402939-18-8CDU N-Cyclohexyl-N-dodecyl urea NCNDEpoxide HydrolaseepoxyeicosatrienoicacidbloodpressureEETantihypertensiveInhibitorinhibitorinhibit

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