2. GPCR/G Protein
  3. GLP Receptor
  4. SAR441255 TFA

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys.

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SAR441255 TFA Chemical Structure

SAR441255 TFA Chemical Structure

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Other Forms of SAR441255 TFA:

SAR441255 TFA Related Antibodies

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Description

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].

IC50 & Target

IC50: GLP-1/GIP/GCG receptor[1]
Molecular Weight

4866.56 (free base)

Formula

C225H3555N57O63.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence Shortening

H-{Aib}-HGTFTSDLSKL-{Lys(γGlu-γGlu-Palm acid)}-EEQRQ-{Aib}-EFIEWLKA-{d-Ala}-GPPS-{Aib}-KPPPK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation
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SAR441255 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR441255SAR 441255SAR-441255GLP ReceptorGlucagonmetabolic diseaseobesitytype 2 diabetemonkeyInhibitorinhibitorinhibit

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