Poly(deoxyadenylic-thymidylic) acid sodium  (Synonyms: Poly(dA:dT) sodium)

Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase^[1][2][3].

Poly(deoxyadenylic-thymidylic) acid sodium (25 min) serves as a functional exogenous template for free RNA polymerase I, II, and III in the nuclei of isolated fetal rat cerebral cortical neurons, allowing the determination of their activities, which increase with fetal age^[1].
Poly(deoxyadenylic-thymidylic) acid sodium stimulates the production of heat-resistant STING activators and induces IRF3 dimerization in cytoplasmic extracts of L929-shSTING^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₁₀H₁₅N₂O₈P.C₁₀H₁₄N₅O₆P)_x.xNa

86828-69-5

Solid

White to light yellow

O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2O)([H])O[C@@H]2CO[P](O)(O)=O.NC3=C4C(N([C@](C[C@@H]5O)([H])O[C@@H]5CO[P](O)(O)=O)C=N4)=NC=N3.[Na].[x].[x]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Graham EM, et al. Effect of gestational age and hypoxia on activity of ribonucleic acid polymerase in fetal guinea pig brain. Am J Obstet Gynecol. 2001;184(4):736-742.  [Content Brief]

  [2]. Zhang Z, et al. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol. 2011;12(10):959-965. Published 2011 Sep 4.  [Content Brief]

  [3]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013;339(6121):826-830.  [Content Brief]