Succinic acid sodium
Based on 7 publication(s) in Google Scholar
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.
For research use only. We do not sell to patients.
- CAS No.: 14047-56-4
- Formula: C4H6O4.xNa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Succinic acid sodium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
- Cell Mol Gastroenterol Hepatol. 2026 Apr 15;20(8):101789. [Abstract]
- Cell Rep. 2026 Feb 25;45(3):117047. [Abstract]
- Inflamm Res. 2025 Nov 6;74(1):156. [Abstract]
- Oncol Res. 2026 Jan 19;34(2):25. [Abstract]
- Water Air Soil Pollut. 232, 473 (2021).
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RT-PCR
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WB
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RT-PCR
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RT-PCR
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RT-PCR
Biological Activity
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TET1 |
succinic acid (3.0, 6.0, and 12.0 mg/kg, IP) caused significant increases in food intake during 5 min when compared with the vehicle[1].
Succinic acid sodium (100 mM) infused into rat colons significantly inhibits colonic cell proliferation and reduced crypt size[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14047-56-4
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Formula C4H6O4.xNa
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SMILES
O=C(CCC(O)=O)O.[Na].[x]
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Synonyms
Wormwood acid sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Host Microbe
Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer. [Abstract]2023 May 10;31(5):781-797.e9. PMID: 37130518
Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant
Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).
Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.
Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).
Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).
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Cell Mol Gastroenterol Hepatol
Microbial Monotherapy With Leuconostoc sp LB-P8 Improves Inflammation and Fibrosis in Mouse Primary Sclerosing Cholangitis by Inhibiting Transforming Growth Factor β1/SMAD Signaling. [Abstract]2026 Apr 15;20(8):101789. PMID: 41997362 -
Cell Rep
Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis. [Abstract]2026 Feb 25;45(3):117047. PMID: 41746808 -
Inflamm Res
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury. [Abstract]2025 Nov 6;74(1):156. PMID: 41196309 -
Oncol Res
SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]2026 Jan 19;34(2):25. PMID: 41613800 -
Purity & Documentation
References
[1]. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. [Content Brief]
[2]. Inagaki A, et al. Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. J Nutr Sci Vitaminol (Tokyo). 2007 Aug;53(4):377-9. [Content Brief]
[3]. Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22(4):1072. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Succinic acid sodium Related Classifications
HY-W396714 Related Classifications
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