2. Membrane Transporter/Ion Channel Epigenetics
  3. Potassium Channel TET Protein
  4. Succinic acid sodium

Succinic acid sodium  (Synonyms: Wormwood acid sodium)

Cat. No.: HY-W396714
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Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.

For research use only. We do not sell to patients.

CAS No. : 14047-56-4

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Succinic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant

    Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).

    Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.

    Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).

    Succinic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).

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    Description

    Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research[1][2][3].

    IC50 & Target[1][2][3]

    TET1

     

    In Vivo

    Succinic acid sodium (3.0 or 6.0 mg/kg, PO) increased the percentage of entries into open arms and of time spent on open arms[1].
    succinic acid (3.0, 6.0, and 12.0 mg/kg, IP) caused significant increases in food intake during 5 min when compared with the vehicle[1].
    Succinic acid sodium (100 mM) infused into rat colons significantly inhibits colonic cell proliferation and reduced crypt size[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Formula

    C4H6O4.xNa
    CAS No.
    SMILES

    O=C(CCC(O)=O)O.[Na].[x]
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Succinic acid sodium Related Classifications

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    Keywords:

    Succinic acid14047-56-4Wormwood acidPotassium ChannelTET ProteinKcsATET enzymeTen-eleven-translocation (TET) proteinTen-eleven translocation (TET) methylcytosine dioxygenaseanxiolyticshort-chain fatty acidslarge intestinecell divisiongestational hypertensionInhibitorinhibitorinhibit

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