Stearidonic acid  (Synonyms: 6Z,9Z,12Z,15Z-Octadecatetraenoic acid)

Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease^[1][2].

Stearidonic acid (10-20 μM; 30 min) inhibits 5-lipoxygenase pathway product formation in isolated human leukocytes, with 20 μM reducing leukotriene synthesis by 50% and 10 μM reducing leukotriene synthesis by 35%^[1].
Stearidonic acid (10-100 μM; 30 min) induces dose-dependent inhibition of 5-HETE formation in isolated human leukocytes, with 100 μM reducing 5-HETE levels by 45%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stearidonic acid (1% in diet; oral; daily; 21 days) fed to rats produces a two-fold greater enrichment of plasma EPA than an equivalent α-Linolenic acid (HY-N0728) diet^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

276.41

C₁₈H₂₈O₂

20290-75-9

Liquid

Colorless to light yellow

CC/C=C\C/C=C\C/C=C\C/C=C\CCCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Guichardant M, et al. Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid. Lipids. 1993;28(4):321-324.  [Content Brief]

  [2]. Walker CG, et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. Nutrition. 2013;29(2):363-369.  [Content Brief]