1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. (Rac)-WAY-161503

(Rac)-WAY-161503 

Cat. No.: HY-103138A Purity: >99.0%
Handling Instructions

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.

For research use only. We do not sell to patients.

(Rac)-WAY-161503 Chemical Structure

(Rac)-WAY-161503 Chemical Structure

CAS No. : 75704-24-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects[1][2].

IC50 & Target[2]

5-HT2C Receptor

4 nM (Ki)

5-HT2C Receptor

12 nM (EC50)

In Vivo

(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT2A KO mice[1].

Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Intraperitoneal injection
Result: Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.
Molecular Weight

272.13

Formula

C₁₁H₁₁Cl₂N₃O

CAS No.

75704-24-4

SMILES

O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

(Rac)-WAY-1615035-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2Cinositolphosphatecalciummobilizationarachidonicacidanti-obesityantidepressantInhibitorinhibitorinhibit

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(Rac)-WAY-161503
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