75704-24-4
75704-24-4
Chemical Structure
(Rac)-WAY-161503
- CAS No.: 75704-24-4
- Formula:C11H11Cl2N3O
- Molecular Weight:272.13
IUPAC Name: 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one
InChIKey: PHGWDAICBXUJDU-UHFFFAOYSA-N
SMILES: O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1
Biological Activity: (Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Rac)-WAY-161503 | 98.49% | (Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-103138(Rac)-WAY-161503 hydrochloride -
Similarity Score 0.55
HY-173626EN1441 -
Similarity Score 0.54
HY-W1008871CRBN ligand-202 -
Similarity Score 0.54
HY-W1115186CRBN ligand-900 -
Similarity Score 0.53
HY-W5951113-((4-(Piperazin-1-yl)phenyl)amino)piperidine-2,6-dione (hydrochloride) -
Similarity Score 0.52
HY-W1122143ACRBN ligand-733 -
Similarity Score 0.52
HY-B1884RProcymidone (Standard) -
Similarity Score 0.51
HY-W7613001-(4-Pip-Ph)-DHP-dione -
Similarity Score 0.51
HY-W936871Hydrouracil-(4-CP) -
Explore the MedChemAI to find more analogs
References
- [1]. Halberstadt AL, et al. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul;34(8):1958-67. [Content Brief]
- [2]. Welmaker GS, et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1991-4. [Content Brief]
