2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. (Rac)-WAY-161503 hydrochloride

(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects.

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(Rac)-WAY-161503 hydrochloride

(Rac)-WAY-161503 hydrochloride Chemical Structure

CAS No. : 276695-22-8

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Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-WAY-161503 hydrochloride:

(Rac)-WAY-161503 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (Rac)-WAY-161503 hydrochloride

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Description

(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects[1][2].

IC50 & Target[1]

5-HT2A Receptor

 

5-HT2B Receptor

 

5-HT2C Receptor

 

5-HT2C Receptor

4 nM (Ki)

5-HT2C Receptor

12 nM (EC50)

In Vivo

(Rac)-WAY-161503 (3-30 mg/kg; i.p.; male C57BL/6J mice) hydrochloride dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Antagonized the PGE2-mediated inhibition of LPS-induced TNF-α release from rat whole blood culture, in a dose-dependent way.
Molecular Weight

308.59

Formula

C11H12Cl3N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (324.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2405 mL 16.2027 mL 32.4055 mL
5 mM 0.6481 mL 3.2405 mL 6.4811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2405 mL 16.2027 mL 32.4055 mL 81.0136 mL
5 mM 0.6481 mL 3.2405 mL 6.4811 mL 16.2027 mL
10 mM 0.3241 mL 1.6203 mL 3.2405 mL 8.1014 mL
15 mM 0.2160 mL 1.0802 mL 2.1604 mL 5.4009 mL
20 mM 0.1620 mL 0.8101 mL 1.6203 mL 4.0507 mL
25 mM 0.1296 mL 0.6481 mL 1.2962 mL 3.2405 mL
30 mM 0.1080 mL 0.5401 mL 1.0802 mL 2.7005 mL
40 mM 0.0810 mL 0.4051 mL 0.8101 mL 2.0253 mL
50 mM 0.0648 mL 0.3241 mL 0.6481 mL 1.6203 mL
60 mM 0.0540 mL 0.2700 mL 0.5401 mL 1.3502 mL
80 mM 0.0405 mL 0.2025 mL 0.4051 mL 1.0127 mL
100 mM 0.0324 mL 0.1620 mL 0.3241 mL 0.8101 mL
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(Rac)-WAY-161503 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-WAY-161503276695-22-85-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2Cinositolphosphatecalciummobilizationarachidonicacidanti-obesityantidepressantInhibitorinhibitorinhibit

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