(Rac)-WAY-161503 hydrochloride
Based on 1 publication(s) in Google Scholar
(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects.
For research use only. We do not sell to patients.
- Purity : 99.5%
- CAS No.: 276695-22-8
- Formula: C11H12Cl3N3O
- Molecular Weight:308.59
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (Rac)-WAY-161503 hydrochloride
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
5-HT2C Receptor 4 nM (Ki) |
5-HT2C Receptor 12 nM (EC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1]
-
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Antagonized the PGE2-mediated inhibition of LPS-induced TNF-α release from rat whole blood culture, in a dose-dependent way.
Chemical Information
-
CAS No. 276695-22-8
-
Appearance Solid
-
Molecular Weight 308.59
-
Formula C11H12Cl3N3O
-
Color White to off-white
-
SMILES
O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Neuropharmacology
Dorsal raphe serotonergic neurons facilitate arousal from sevoflurane anesthesia by heterogeneously modulating neuronal activity in the basolateral amygdala. [Abstract]2026 Mar 15:286:110815. PMID: 41448357
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (324.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Halberstadt AL, et al. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul;34(8):1958-67. [Content Brief]
[2]. Welmaker GS, et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1991-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2405 mL | 16.2027 mL | 32.4055 mL | 81.0136 mL |
| 5 mM | 0.6481 mL | 3.2405 mL | 6.4811 mL | 16.2027 mL | |
| 10 mM | 0.3241 mL | 1.6203 mL | 3.2405 mL | 8.1014 mL | |
| 15 mM | 0.2160 mL | 1.0802 mL | 2.1604 mL | 5.4009 mL | |
| 20 mM | 0.1620 mL | 0.8101 mL | 1.6203 mL | 4.0507 mL | |
| 25 mM | 0.1296 mL | 0.6481 mL | 1.2962 mL | 3.2405 mL | |
| 30 mM | 0.1080 mL | 0.5401 mL | 1.0802 mL | 2.7005 mL | |
| 40 mM | 0.0810 mL | 0.4051 mL | 0.8101 mL | 2.0253 mL | |
| 50 mM | 0.0648 mL | 0.3241 mL | 0.6481 mL | 1.6203 mL | |
| 60 mM | 0.0540 mL | 0.2700 mL | 0.5401 mL | 1.3502 mL | |
| 80 mM | 0.0405 mL | 0.2025 mL | 0.4051 mL | 1.0127 mL | |
| 100 mM | 0.0324 mL | 0.1620 mL | 0.3241 mL | 0.8101 mL |
(Rac)-WAY-161503 hydrochloride Related Classifications
HY-103138 Related Classifications
Powered by Bioz