5-Bromo-L-tryptophan
Based on 1 publication(s) in Google Scholar
5-Bromo-L-tryptophan is a substrate of PLP-dependent enzyme AetE, as well as an indole alkaloid and Amino acid derivative. 5-Bromo-L-tryptophan can be isolated from Semenospongia sp. 5-Bromo-L-tryptophan can be converted into 5-bromoindole (HY-30236) via AetE-mediated catalysis. 5-Bromo-L-tryptophan is applicable to colon cancer research.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 25197-99-3
- Formula: C11H11BrN2O2
- Molecular Weight:283.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 5-Bromo-L-tryptophan
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Biological Activity
5-Bromo-L-tryptophan is converted to 5-bromoindole (HY-30236) by purified PLP-dependent tryptophanase AetE[1].
5-Bromo-L-tryptophan (72 h) shows no cytotoxic activity against HCT-116 p53+/+ and HCT-116 p53-/- human colon carcinoma cells up to 177 μM, with an IC50 >177 μM in both cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 p53+/+ human colon carcinoma cells, HCT-116 p53-/- human colon carcinoma cells
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Concentration:Unclear
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Incubation Time:72 h
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Result:Did not exhibit cytotoxicity up to the maximum tested concentration.
Resulted in an IC50 value greater than 177 μM in both HCT-116 p53+/+ and HCT-116 p53-/- cell lines.
Chemical Information
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CAS No. 25197-99-3
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Appearance Solid
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Molecular Weight 283.13
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Formula C11H11BrN2O2
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Color Off-white to light brown
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
H2O : 5.65 mg/mL (19.96 mM; ultrasonic and warming and heat to 60°C)
DMSO : 1 mg/mL (3.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Adak S, et al. From Tryptophan to Toxin: Nature's Convergent Biosynthetic Strategy to Aetokthonotoxin. Journal of the American Chemical Society. 2022 Feb 23;144(7):2861-2866. [Content Brief]
[2]. Tasdemir D, et al. Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2002;57(9-10):914-22. [Content Brief]
[3]. Adak S, et al. Metagenomic Identification of Brominated Indole Biosynthetic Machinery from Cyanobacteria. Journal of natural products. 2025 Jul 25;88(7):1734-1742. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 3.5319 mL | 17.6597 mL | 35.3195 mL | 88.2987 mL |
| H2O | 5 mM | 0.7064 mL | 3.5319 mL | 7.0639 mL | 17.6597 mL |
| 10 mM | 0.3532 mL | 1.7660 mL | 3.5319 mL | 8.8299 mL | |
| 15 mM | 0.2355 mL | 1.1773 mL | 2.3546 mL | 5.8866 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
5-Bromo-L-tryptophan Related Classifications
HY-20897A Related Classifications
Powered by Bioz
- 5-Bromo-L-tryptophan
- 25197-99-3
- Amino Acid Derivatives
- Drug Intermediate
- AetE
- Aetokthonos hydrillicola
- 5-bromoindole
- cyanobacterial neurotoxin aetokthonotoxin
- PLP-dependent enzyme
- HCT-116 p53-/-
- flavin-dependent halogenase AetA
- human colon carcinoma cells
- HCT-116 p53+/+
- PLP-dependent tryptophanase
- Inhibitor
- inhibitor
- inhibit