Nicotinic acid mononucleotide triethylamine

Name: Nicotinic acid mononucleotide triethylamine
Brand: MedChemExpress
SKU: HY-128700A
Rating: 4.5 (1 reviews)

Cat. No.: HY-128700A Purity: 99.36%: Data Sheet
COA

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Handling Instructions
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Nicotinic acid mononucleotide triethylamine acts as a SARM1 inhibitor and a NAD⁺ biosynthesis intermediate, with an IC₅₀ value of 93.3 μM against SARM1. Nicotinic acid mononucleotide triethylamine exerts axon-protective effects, delays axonal degeneration, elevates NAD⁺ levels, enhances Sirt1 activity, improves myocardial capillary density and alleviates myocardial fibrosis. Nicotinic acid mononucleotide triethylamine reverses diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD⁺ levels. Nicotinic acid mononucleotide triethylamine is applicable to research related to cancer, multiple sclerosis, diabetic cardiomyopathy, neurodegenerative diseases and Huntington's disease.

For research use only. We do not sell to patients.

Nicotinic acid mononucleotide triethylamine Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nicotinic acid mononucleotide triethylamine:

Nicotinic acid mononucleotide In-stock

1 Publications Citing Use of MCE Nicotinic acid mononucleotide triethylamine

•Diabetes Res Clin Pract. 2023 Dec:206:111014. [Abstract]

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Nicotinic acid mononucleotide (0-250 μM; assay duration) triethylamine inhibits the NAD⁺ hydrolase activity of full-length human SARM1 by binding to its N-terminal ARM domain; its IC₅₀ is 93.3 μM in the absence of NMN, while this inhibitory effect is attenuated in the presence of 5 μM NMN (IC₅₀ = 147.2 μM)^[1].
Nicotinic acid mononucleotide triethylamine delays axonal degeneration of mammalian axons by restoring reduced intracellular NAD⁺ levels^[3].
Nicotinic acid mononucleotide (NAM) triethylamine increases the expression of Sirt1 and the phosphorylation level of eNOS in human umbilical vein endothelial cells (HUVECs) treated with high glucose^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nicotinic acid mononucleotide (NAM) (400 mg/kg/day; i.p.; daily; 8 weeks) triethylamine partially reverses streptozotocin (HY-13753)-induced diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD⁺ levels, improving cardiac function and ultrastructure, enhancing capillary density, alleviating fibrosis, and restoring Sirt1 expression^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J (8-week-old male; streptozotocin-induced diabetic)^[4]
Dosage:	400 mg/kg/day
Administration:	i.p.; daily; 8 weeks
Result:	Partially increased myocardial NAD+ levels in diabetic mice. Partially reversed impaired left ventricular ejection fraction (LVEF) and fractional shortening (FS) relative to untreated diabetic mice. Improved myocardial ultrastructural abnormalities (reduced Z-line misalignment, mitochondrial swelling, and myofibril disorganization). Increased myocardial capillary density relative to untreated diabetic mice. Reduced myocardial expression of fibrosis markers TGF-β1 and collagen I relative to untreated diabetic mice. Restored myocardial Sirt1 mRNA and protein expression relative to untreated diabetic mice. Had no effect on blood glucose or body weight in diabetic mice, and no significant effect on interventricular septal thickness (IVSD) or left ventricular posterior wall thickness (LVPWD).

Molecular Weight

506.97

Formula

C₁₁H₁₄NO₉P.1.7C₆H₁₅N

Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@H]([N+]2=CC=CC(C([O-])=O)=C2)O[C@H](COP(O)(O)=O)[C@H]1O.CCN(CC)CC.[1.7]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (197.25 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (197.25 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9725 mL	9.8625 mL	19.7250 mL
5 mM	0.3945 mL	1.9725 mL	3.9450 mL
10 mM	0.1973 mL	0.9863 mL	1.9725 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (245 KB) HNMR (284 KB) CNMR (291 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. Sasaki Y, et al. Nicotinic acid mononucleotide triethylamine is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842. [Content Brief]

[2]. O'Hara JK, et al. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. PLoS One. 2014;9(4):e94061. Published 2014 Apr 18. [Content Brief]

[3]. Khan JA, et al. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007;11(5):695-705. [Content Brief]

[4]. Zeng F, et al. ACMSD mediated de novo NAD⁺ biosynthetic impairment in cardiac endothelial cells as a potential therapeutic target for diabetic cardiomyopathy. Diabetes Res Clin Pract. 2023;206:111014. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.9725 mL	9.8625 mL	19.7250 mL	49.3126 mL
	5 mM	0.3945 mL	1.9725 mL	3.9450 mL	9.8625 mL
	10 mM	0.1973 mL	0.9863 mL	1.9725 mL	4.9313 mL
	15 mM	0.1315 mL	0.6575 mL	1.3150 mL	3.2875 mL
	20 mM	0.0986 mL	0.4931 mL	0.9863 mL	2.4656 mL
	25 mM	0.0789 mL	0.3945 mL	0.7890 mL	1.9725 mL
	30 mM	0.0658 mL	0.3288 mL	0.6575 mL	1.6438 mL
	40 mM	0.0493 mL	0.2466 mL	0.4931 mL	1.2328 mL
	50 mM	0.0395 mL	0.1973 mL	0.3945 mL	0.9863 mL
	60 mM	0.0329 mL	0.1644 mL	0.3288 mL	0.8219 mL
	80 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.6164 mL
	100 mM	0.0197 mL	0.0986 mL	0.1973 mL	0.4931 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.