SCD1-IN-1
SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition.
For research use only. We do not sell to patients.
- CAS No.: 1111078-63-7
- Formula: C20H20F3NO4
- Molecular Weight:395.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
SCD1[1].
In Vitro
SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hamster ear model[1]
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Dosage:1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL.
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Administration:Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks.
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Result:Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.
Chemical Information
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CAS No. 1111078-63-7
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Molecular Weight 395.37
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Formula C20H20F3NO4
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SMILES
FC(F)(F)C(C=CC=C1)=C1O[C@@H]2CN(CC2)C(COC3=CC=C(C=C3)CO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCD1-IN-1 Related Classifications
HY-150125 Related Classifications
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