1. Metabolic Enzyme/Protease
  2. Stearoyl-CoA Desaturase (SCD)
  3. SCD1-IN-1

SCD1-IN-1 

Cat. No.: HY-150125
Handling Instructions

SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition.

For research use only. We do not sell to patients.

SCD1-IN-1 Chemical Structure

SCD1-IN-1 Chemical Structure

CAS No. : 1111078-63-7

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Description

SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1].

IC50 & Target

SCD1[1].

In Vitro

SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hamster ear model[1]
Dosage: 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL.
Administration: Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks.
Result: Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.
Molecular Weight

395.37

Formula

C20H20F3NO4

CAS No.
SMILES

FC(F)(F)C(C=CC=C1)=C1O[[email protected]@H]2CN(CC2)C(COC3=CC=C(C=C3)CO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SCD1-IN-1
Cat. No.:
HY-150125
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