N-Acetyl-L-proline
Based on 1 Customer Validation
N-Acetyl-L-proline is an N-acetylated amino acid derivative of L-proline (HY-Y0252), as well as a stereospecific substrate of N-acyl-L-proline-acylase. N-Acetyl-L-proline can be used for the synthesis of the non-steroidal anti-inflammatory drug Aceprol.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 68-95-1
- Formula: C7H11NO3
- Molecular Weight:157.17
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human Endogenous Metabolite |
N-Acetyl-L-proline undergoes stereoselective hydrolysis by purified N-acyl-L-proline-acylase derived from Comamonas testosteroni DSM 5416 in a system at 30 ℃ and pH 7.0. This enzyme has a specific activity of 85.2 U/mg, a KM value of 5 mM for the substrate, and enables complete conversion of the substrate after continuous incubation for 2 h[2].
N-Acetyl-L-proline derivatives with modified carboxyl groups show no catalytic reactivity toward purified N-acyl-L-proline-acylase from Comamonas testosteroni DSM 5416, which verifies that free carboxyl group is essential for substrate-enzyme binding[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 68-95-1
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Appearance Solid
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Molecular Weight 157.17
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Formula C7H11NO3
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Color White to off-white
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : ≥ 100 mg/mL (636.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.3625 mL | 31.8127 mL | 63.6254 mL | 159.0634 mL |
| 5 mM | 1.2725 mL | 6.3625 mL | 12.7251 mL | 31.8127 mL | |
| 10 mM | 0.6363 mL | 3.1813 mL | 6.3625 mL | 15.9063 mL | |
| 15 mM | 0.4242 mL | 2.1208 mL | 4.2417 mL | 10.6042 mL | |
| 20 mM | 0.3181 mL | 1.5906 mL | 3.1813 mL | 7.9532 mL | |
| 25 mM | 0.2545 mL | 1.2725 mL | 2.5450 mL | 6.3625 mL | |
| 30 mM | 0.2121 mL | 1.0604 mL | 2.1208 mL | 5.3021 mL | |
| 40 mM | 0.1591 mL | 0.7953 mL | 1.5906 mL | 3.9766 mL | |
| 50 mM | 0.1273 mL | 0.6363 mL | 1.2725 mL | 3.1813 mL | |
| 60 mM | 0.1060 mL | 0.5302 mL | 1.0604 mL | 2.6511 mL | |
| 80 mM | 0.0795 mL | 0.3977 mL | 0.7953 mL | 1.9883 mL | |
| 100 mM | 0.0636 mL | 0.3181 mL | 0.6363 mL | 1.5906 mL |
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