5,7-Dichlorokynurenic acid sodium

5,7-Dichlorokynurenic acid (30.0-100.0 mg/kg; i.p.; single dose) sodium produces anxiolytic-like effects in the social interaction model, increasing social interaction time by +37% at 30.0 mg/kg and +32% at 100.0 mg/kg, with reduced motor activity at the highest dose^[2].
5,7-Dichlorokynurenic acid (100.0 mg/kg; i.p.; single dose) sodium produces anxiolytic-like effects in the elevated plus maze model, increasing open arm exploration time by +41% at 100.0 mg/kg, with reduced motor activity^[2].
5,7-Dichlorokynurenic acid (100.0-173.0 mg/kg; i.p.; single dose) sodium disinhibits suppressed conflict responding in the Cook and Davidson conditioned anxiety model at 100.0 mg/kg and 173.0 mg/kg without altering non-punished responding^[2].
5,7-Dichlorokynurenic acid (10.0-100.0 mg/kg; i.p.; single dose) sodium does not generalize to the MK-801 discriminative cue at 10.0 mg/kg, and shows minimal partial generalization in 1 of 4 rats at 100.0 mg/kg^[2].