5,7-Dichlorokynurenic acid sodium  (Synonyms: 5,7-DCKA sodium)

5,7-Dichlorokynurenic acid (5,7-DCKA) sodium is a selective and competitive antagonist of the glycine site on NMDA receptor with a K_B of 65 nM. 5,7-Dichlorokynurenic acid sodium reduces NMDA-induced neuron injury. 5,7-Dichlorokynurenic acid sodium increases social interaction time, increases open arm exploration time, disinhibits suppressed conflict responding in rodent models. 5,7-Dichlorokynurenic acid sodium exhibits anxiolytic-like activity in rodent models and supports exploration of glycine’s role in NMDA receptor-mediated synaptic transmission^[1][2].

5,7-dichlorokynurenic acid (0.2-400 μM) sodium is a potent, competitive antagonist of the glycine site on NMDA receptors expressed in rat brain mRNA-injected Xenopus oocytes, with a K_B of 65 nM, and is 509-fold more selective for this site than for kainate receptors^[1].
5,7-dichlorokynurenic acid (40 nM-10 μM; 60 min on ice) sodium potently displaces [³H]glycine from strychnine-insensitive glycine sites on rat brain cortex membranes with a K_i of 40 nM, and does not bind to the NMDA recognition site at 10 μM^[1].
5,7-dichlorokynurenic acid (1-10 μM) sodium reduces NMDA-induced neuronal injury in primary rat cortical cell cultures, with 1 μM yielding 55-79% protection and 10 μM yielding 62-90% protection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5,7-Dichlorokynurenic acid (30.0-100.0 mg/kg; i.p.; single dose) sodium produces anxiolytic-like effects in the social interaction model, increasing social interaction time by +37% at 30.0 mg/kg and +32% at 100.0 mg/kg, with reduced motor activity at the highest dose^[2].
5,7-Dichlorokynurenic acid (100.0 mg/kg; i.p.; single dose) sodium produces anxiolytic-like effects in the elevated plus maze model, increasing open arm exploration time by +41% at 100.0 mg/kg, with reduced motor activity^[2].
5,7-Dichlorokynurenic acid (100.0-173.0 mg/kg; i.p.; single dose) sodium disinhibits suppressed conflict responding in the Cook and Davidson conditioned anxiety model at 100.0 mg/kg and 173.0 mg/kg without altering non-punished responding^[2].
5,7-Dichlorokynurenic acid (10.0-100.0 mg/kg; i.p.; single dose) sodium does not generalize to the MK-801 discriminative cue at 10.0 mg/kg, and shows minimal partial generalization in 1 of 4 rats at 100.0 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

280.04

C₁₀H₄Cl₂NNaO₃

1184986-70-6

O=C(C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1)O[Na]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. D McNamara, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20.  [Content Brief]

  [2]. Corbett R, et al. Effects of 5,7 dichlorokynurenic acid on conflict, social interaction and plus maze behaviors. Neuropharmacology. 1993;32(5):461-466.  [Content Brief]