2. 5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid  (Synonyms: 5,7-DCKA)

Cat. No.: HY-100834 Purity: 99.91%
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5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures.

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5,7-Dichlorokynurenic acid Chemical Structure

5,7-Dichlorokynurenic acid Chemical Structure

CAS No. : 131123-76-7

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5 mg USD 50 In-stock
10 mg USD 85 In-stock
25 mg USD 185 In-stock
50 mg USD 315 In-stock
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Other Forms of 5,7-Dichlorokynurenic acid:

5,7-Dichlorokynurenic acid Related Antibodies

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Description

5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1].

Molecular Weight

258.06

Formula

C10H5Cl2NO3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (96.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8751 mL 19.3753 mL 38.7507 mL
5 mM 0.7750 mL 3.8751 mL 7.7501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8751 mL 19.3753 mL 38.7507 mL 96.8767 mL
5 mM 0.7750 mL 3.8751 mL 7.7501 mL 19.3753 mL
10 mM 0.3875 mL 1.9375 mL 3.8751 mL 9.6877 mL
15 mM 0.2583 mL 1.2917 mL 2.5834 mL 6.4584 mL
20 mM 0.1938 mL 0.9688 mL 1.9375 mL 4.8438 mL
25 mM 0.1550 mL 0.7750 mL 1.5500 mL 3.8751 mL
30 mM 0.1292 mL 0.6458 mL 1.2917 mL 3.2292 mL
40 mM 0.0969 mL 0.4844 mL 0.9688 mL 2.4219 mL
50 mM 0.0775 mL 0.3875 mL 0.7750 mL 1.9375 mL
60 mM 0.0646 mL 0.3229 mL 0.6458 mL 1.6146 mL
80 mM 0.0484 mL 0.2422 mL 0.4844 mL 1.2110 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,7-Dichlorokynurenic acid131123-76-75,7-DCKAInhibitorinhibitorinhibit

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