1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. D-AP5

D-AP5 (Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)

Cat. No.: HY-100714A
Handling Instructions

D-AP5 is a NMDA receptor antagonist.

For research use only. We do not sell to patients.

D-AP5 Chemical Structure

D-AP5 Chemical Structure

CAS No. : 79055-68-8

Size Price Stock Quantity
10 mM * 1 mL in Water USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

D-AP5 is a NMDA receptor antagonist.

IC50 & Target

NMDA[1]

In Vivo

D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented[1]. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[2].

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (253.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0728 mL 25.3640 mL 50.7279 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL
10 mM 0.5073 mL 2.5364 mL 5.0728 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Male Lister hooded rats are used in this study. They are housed individually and have free access to food and water at all times except for 12 hr prior to surgery. Animals are implanted with 30 mM D-AP5 (N=6) and tested in the water maze[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

197.13

Formula

C₅H₁₂NO₅P

CAS No.

79055-68-8

SMILES

N[[email protected]](CCCP(O)(O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
D-AP5
Cat. No.:
HY-100714A
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D-AP5

Cat. No.: HY-100714A