1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. D-AP5

D-AP5 (Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)

Cat. No.: HY-100714A Purity: >95.0%
Handling Instructions

D-AP5 is a NMDA receptor antagonist.

For research use only. We do not sell to patients.

D-AP5 Chemical Structure

D-AP5 Chemical Structure

CAS No. : 79055-68-8

Size Price Stock Quantity
10 mM * 1  mL in Water USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 585 In-stock
Estimated Time of Arrival: December 31
100 mg USD 805 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

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D-AP5 is a NMDA receptor antagonist.

IC50 & Target


In Vivo

D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented[1]. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[2].

Molecular Weight







N[[email protected]](CCCP(O)(O)=O)C(O)=O


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (253.64 mM; Need ultrasonic)

Ethanol : 2 mg/mL (10.15 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0728 mL 25.3640 mL 50.7279 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL
10 mM 0.5073 mL 2.5364 mL 5.0728 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Male Lister hooded rats are used in this study. They are housed individually and have free access to food and water at all times except for 12 hr prior to surgery. Animals are implanted with 30 mM D-AP5 (N=6) and tested in the water maze[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: >95.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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