1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. D-AP5

D-AP5 (Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)

Cat. No.: HY-100714A Purity: ≥98.0%
Handling Instructions

D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors.

For research use only. We do not sell to patients.

D-AP5 Chemical Structure

D-AP5 Chemical Structure

CAS No. : 79055-68-8

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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].

IC50 & Target

NMDA[1]

In Vivo

D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented[2].
D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

197.13

Formula

C₅H₁₂NO₅P

CAS No.
SMILES

N[[email protected]](CCCP(O)(O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 27.78 mg/mL (140.92 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0728 mL 25.3640 mL 50.7279 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL
10 mM 0.5073 mL 2.5364 mL 5.0728 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥98.0%

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Keywords:

D-AP5D-APV D-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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D-AP5
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HY-100714A
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