DL-AP5 lithium
Based on 3 publication(s) in Google Scholar
DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina.
For research use only. We do not sell to patients.
- CAS No.: 125229-62-1
- Formula: C5H11LiNO5P
- Molecular Weight:203.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) DL-AP5 lithium
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Biological Activity
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NMDA Receptor |
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (180-230 g)[3]
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Dosage:1, 3.2 and 10 μg/rat
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Administration:Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
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Result:Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
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Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
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Dosage:0, 2.5, 5, and 10 nmol; in a volume of 10 μL
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Administration:Intracerebroventricular injection
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Result:Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
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Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
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Dosage:5 nmol
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Administration:Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
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Result:Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
Chemical Information
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CAS No. 125229-62-1
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Molecular Weight 203.06
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Formula C5H11LiNO5P
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SMILES
NC(CCCP(O)(O)=O)C(O[Li])=O
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Synonyms
2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Neuron
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits. [Abstract]2026 Mar 26:S0896-6273(26)00120-0. PMID: 41895265 -
Int J Biol Macromol
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. [Abstract]2024 Oct 28:136767. PMID: 39476923
DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]
Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.
DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]
The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2fl/fl and Setd2-cKO mice.
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DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.
DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.
DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.
DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.
DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.
DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.
Purity & Documentation
References
[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]
[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]
[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]
[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]
[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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