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DL-AP5 sodium

(Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina.

For research use only. We do not sell to patients.

  • CAS No.: 1303993-72-7
  • Formula: C5H11NNaO5P
  • Molecular Weight:219.11
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • DL-AP5 sodium Chemical Structure
    DL-AP5 sodium Chemical Structure
  • Experimental Validation Results for DL-AP5 sodium
  • Experimental Validation Results for DL-AP5 sodium
  • Experimental Validation Results for DL-AP5 sodium
  • Experimental Validation Results for DL-AP5 sodium
  • Experimental Validation Results for DL-AP5 sodium
CAS No.: 1303993-72-7
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  • DL-AP5 sodium Chemical Structure
    DL-AP5 sodium Chemical Structure
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    DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

    Customer Validation
     DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.

  • 1/16

    DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

    Customer Validation
     DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.

  • 1/16

    DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

    Customer Validation
     DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.

  • 1/16

    DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

    Customer Validation
     Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.

  • 1/16

    DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

    Customer Validation
     The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2fl/fl and Setd2-cKO mice.

  • DL-AP5 sodium