DL-AP5 sodium
Based on 3 publication(s) in Google Scholar
DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina.
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- Pureté: 99.2%
- CAS No.: 1303993-72-7
- Formule: C5H11NNaO5P
- Masse moléculaire:219.11
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
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NMDA Receptor |
In Vitro
In Vivo
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (180-230 g)[3]
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Dosage:1, 3.2 and 10 μg/rat
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Administration:Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
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Result:Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
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Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
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Dosage:0, 2.5, 5, and 10 nmol; in a volume of 10 μL
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Administration:Intracerebroventricular injection
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Result:Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
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Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
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Dosage:5 nmol
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Administration:Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
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Result:Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
Chemical Information
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CAS No. 1303993-72-7
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Appearance Solid
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Masse moléculaire 219.11
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Formule C5H11NNaO5P
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Color White to off-white
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SMILES
NC(CCCP(O)(O)=O)C(O[Na])=O
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Synonyms
2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Neuron
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits. [Abstract]2026 Mar 26:S0896-6273(26)00120-0. PMID: 41895265 -
Int J Biol Macromol
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. [Abstract]2024 Dec;282(Pt 5):136767. PMID: 39476923
DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec;282(Pt 5):136767. [Abstract]
Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.
DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec;282(Pt 5):136767. [Abstract]
The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2fl/fl and Setd2-cKO mice.
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DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.
DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.
DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.
DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.
DL-AP5 sodium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.
DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.
Solvant et solubilité
In Vitro:
H2O : 100 mg/mL (456.39 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]
[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]
[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]
[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]
[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5639 mL | 22.8196 mL | 45.6392 mL | 114.0979 mL |
| 5 mM | 0.9128 mL | 4.5639 mL | 9.1278 mL | 22.8196 mL | |
| 10 mM | 0.4564 mL | 2.2820 mL | 4.5639 mL | 11.4098 mL | |
| 15 mM | 0.3043 mL | 1.5213 mL | 3.0426 mL | 7.6065 mL | |
| 20 mM | 0.2282 mL | 1.1410 mL | 2.2820 mL | 5.7049 mL | |
| 25 mM | 0.1826 mL | 0.9128 mL | 1.8256 mL | 4.5639 mL | |
| 30 mM | 0.1521 mL | 0.7607 mL | 1.5213 mL | 3.8033 mL | |
| 40 mM | 0.1141 mL | 0.5705 mL | 1.1410 mL | 2.8524 mL | |
| 50 mM | 0.0913 mL | 0.4564 mL | 0.9128 mL | 2.2820 mL | |
| 60 mM | 0.0761 mL | 0.3803 mL | 0.7607 mL | 1.9016 mL | |
| 80 mM | 0.0570 mL | 0.2852 mL | 0.5705 mL | 1.4262 mL | |
| 100 mM | 0.0456 mL | 0.2282 mL | 0.4564 mL | 1.1410 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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