79055-68-8
79055-68-8
Chemical Structure
D-AP5
Synonym(s): D-APV; D-2-Amino-5-phosphonovaleric acid
- CAS No.: 79055-68-8
- Formula:C5H12NO5P
- Molecular Weight:197.13
IUPAC Name: (R)-2-amino-5-phosphonopentanoic acid
InChIKey: VOROEQBFPPIACJ-SCSAIBSYSA-N
SMILES: N[C@H](CCCP(O)(O)=O)C(O)=O
Biological Activity: D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].
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D-AP5 | 99.94% | D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors. | ||||||||||||||||||||
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D-AP5 (Standard) | ≥98% | D-AP5 (Standard) is the analytical standard of D-AP5 (HY-100714A). This product is intended for research and analytical applications. D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors. | ||||||||||||||||||||
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References
- [1]. R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75. [Content Brief]
- [2]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34. [Content Brief]
Keywords
