2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Spermidine hydrochloride

Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents.

For research use only. We do not sell to patients.

CAS No. : 334-50-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 19 publication(s) in Google Scholar

Other Forms of Spermidine hydrochloride:

Spermidine hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Spermidine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 8.  [Abstract]

    Spermidine (10 mg/kg; i.p.; starting 7 days prior to irradiation and continuing until 9 days post-irradiation). Immunofluorescence staining confirms significantly enhanced epithelial proliferation in the Spermidine-treated group by day 9 post-radiation. Quantification of PCNA+ basal cells before irradiation and for 9 days post-irradiation (n = 6 mice). Five random images per mouse were analyzed. Scale bar, 100 μm.

    Spermidine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):87-103.e10.  [Abstract]

    Spermidine (40 mg/kg; i.p.; every 2 days 3 times). WT (left, n = 3) or GF (right, n = 5) mice are i.p. injected with Spermidine (40 mg/kg) every 2 days 3 times, and the AWR scores are determined on day 8.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents[1].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Spermidine hydrochloride plays a crucial role of against abiotic stresses, such as salt, drought, heat, and salinity-alkalinity stresses in tomato, cucumber, rice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Spermidine hydrochloride Related Antibodies
    Molecular Weight

    254.63

    Formula

    C7H22Cl3N3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCCCNCCCN.[H]Cl.[H]Cl.[H]Cl
    Structure Classification
    Initial Source

    widespread
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    RT, stored under nitrogen

    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    H2O : 175 mg/mL (687.27 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9273 mL 19.6363 mL 39.2727 mL
    5 mM 0.7855 mL 3.9273 mL 7.8545 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (392.73 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (394 KB)

    COA (242 KB) HNMR (155 KB) RP-HPLC (246 KB) LCMS (88 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.9273 mL 19.6363 mL 39.2727 mL 98.1817 mL
    5 mM 0.7855 mL 3.9273 mL 7.8545 mL 19.6363 mL
    10 mM 0.3927 mL 1.9636 mL 3.9273 mL 9.8182 mL
    15 mM 0.2618 mL 1.3091 mL 2.6182 mL 6.5454 mL
    20 mM 0.1964 mL 0.9818 mL 1.9636 mL 4.9091 mL
    25 mM 0.1571 mL 0.7855 mL 1.5709 mL 3.9273 mL
    30 mM 0.1309 mL 0.6545 mL 1.3091 mL 3.2727 mL
    40 mM 0.0982 mL 0.4909 mL 0.9818 mL 2.4545 mL
    50 mM 0.0785 mL 0.3927 mL 0.7855 mL 1.9636 mL
    60 mM 0.0655 mL 0.3273 mL 0.6545 mL 1.6364 mL
    80 mM 0.0491 mL 0.2455 mL 0.4909 mL 1.2273 mL
    100 mM 0.0393 mL 0.1964 mL 0.3927 mL 0.9818 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Spermidine hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Spermidine334-50-9Endogenous MetabolitecellmembranestabilityphotosystemPSIIH2O2Inhibitorinhibitorinhibit

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