Spermidine hydrochloride
Based on 20 publication(s) in Google Scholar
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 334-50-9
- Formula: C7H22Cl3N3
- Molecular Weight:254.63
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Storage:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
Publications Citing Use of MedChemExpress (MCE) Spermidine hydrochloride
More- Cell. 2026 Jan 22;189(2):418-434.e24. [Abstract]
- Cell Metab. 2025 Jan 7;37(1):87-103.e10. [Abstract]
- Nat Commun. 2025 Dec 8. [Abstract]
- Nat Commun. 2025 Aug 1;16(1):7071. [Abstract]
- Cell Rep Med. 2025 Oct 27:102424. [Abstract]
- J Control Release. 2025 Sep 30;388(Pt 1):114283. [Abstract]
- Clin Cancer Res. 2025 Nov 20. [Abstract]
- EMBO J. 2023 Feb 1;42(3):e111364. [Abstract]
- Aging Cell. 2026 Jan 20;25(2):e70352.
- PLoS Biol. 2024 Jun 27;22(6):e3002672. [Abstract]
- Aquaculture. 2025 Oct 15.
- Sleep Med. 2025 Nov 8:137:108648. [Abstract]
- J Biol Chem. 2024 Nov;300(11):107862. [Abstract]
- PLoS Genet. 2026 Jan 23;22(1):e1012013. [Abstract]
- Vascul Pharmacol. 2026 Jun 16:164:107672. [Abstract]
- Virus Res. 2022 Apr 15:312:198708. [Abstract]
- Exp Eye Res. 2025 Mar 24:110360. [Abstract]
- J Toxicol Sci. 2025;50(10):555-567. [Abstract]
- Res Sq. 2025 Jul 13.
- bioRxiv. 2024 Apr 3:2023.06.02.542933. [Abstract]
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IF
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In Vivo Efficacy Study
All Endogenous Metabolite Isoforms
More
Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Spermidine hydrochloride plays a crucial role of against abiotic stresses, such as salt, drought, heat, and salinity-alkalinity stresses in tomato, cucumber, rice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 334-50-9
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Appearance Solid
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Molecular Weight 254.63
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Formula C7H22Cl3N3
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Color White to off-white
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SMILES
NCCCCNCCCN.[H]Cl.[H]Cl.[H]Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Publications (20)
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Journal Impact Factor
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Most Recent
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Cell
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity. [Abstract]2026 Jan 22;189(2):418-434.e24. PMID: 41448182 -
Cell Metab
Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon. [Abstract]2025 Jan 7;37(1):87-103.e10. PMID: 39366386
Spermidine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):87-103.e10. [Abstract]
Spermidine (40 mg/kg; i.p.; every 2 days 3 times). WT (left, n = 3) or GF (right, n = 5) mice are i.p. injected with Spermidine (40 mg/kg) every 2 days 3 times, and the AWR scores are determined on day 8.
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Nat Commun
2025 Dec 8. PMID: 41361241
Spermidine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 8. [Abstract]
Spermidine (10 mg/kg; i.p.; starting 7 days prior to irradiation and continuing until 9 days post-irradiation). Immunofluorescence staining confirms significantly enhanced epithelial proliferation in the Spermidine-treated group by day 9 post-radiation. Quantification of PCNA+ basal cells before irradiation and for 9 days post-irradiation (n = 6 mice). Five random images per mouse were analyzed. Scale bar, 100 μm.
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Nat Commun
USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4. [Abstract]2025 Aug 1;16(1):7071. PMID: 40750602 -
Cell Rep Med
2025 Oct 27:102424. PMID: 41151579 -
J Control Release
Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer. [Abstract]2025 Sep 30;388(Pt 1):114283. PMID: 41038348 -
Clin Cancer Res
Spermidine Secreted by Apoptotic Cells Enhances Chemotherapy Resistance by Modulating β-Catenin Activity in Osteosarcoma. [Abstract]2025 Nov 20. PMID: 41263700 -
EMBO J
Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development. [Abstract]2023 Feb 1;42(3):e111364. PMID: 36477743 -
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PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
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Sleep Med
Cerebellar GluN2C protects against sleep deprivation-induced cognitive impairment and motor incoordination. [Abstract]2025 Nov 8:137:108648. PMID: 41223665 -
J Biol Chem
Different charged biopolymers induce α-synuclein to form fibrils with distinct structures. [Abstract]2024 Nov;300(11):107862. PMID: 39374778 -
PLoS Genet
A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype. [Abstract]2026 Jan 23;22(1):e1012013. PMID: 41575937 -
Vascul Pharmacol
Spermidine ameliorates BK channel dysfunction in diabetic coronary smooth muscle cells via PKM2/STAT3/FBXO32 axis. [Abstract]2026 Jun 16:164:107672. PMID: 42303097 -
Virus Res
PEDV infection affects the expression of polyamine-related genes inhibiting viral proliferation. [Abstract]2022 Apr 15:312:198708. PMID: 35151773 -
Exp Eye Res
Spermidine mitigates blue-light-induced corneal injury by alleviating oxidative stress and restoring autophagy impairment. [Abstract]2025 Mar 24:110360. PMID: 40139641 -
J Toxicol Sci
Spermidine alleviates sepsis-induced acute kidney injury by suppressing apoptosis and inflammation through modulation of TLR4-mediated signaling. [Abstract]2025;50(10):555-567. PMID: 41034042 -
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bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Solvent & Solubility
H2O : 175 mg/mL (687.27 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (392.73 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.9273 mL | 19.6363 mL | 39.2727 mL | 98.1817 mL |
| 5 mM | 0.7855 mL | 3.9273 mL | 7.8545 mL | 19.6363 mL | |
| 10 mM | 0.3927 mL | 1.9636 mL | 3.9273 mL | 9.8182 mL | |
| 15 mM | 0.2618 mL | 1.3091 mL | 2.6182 mL | 6.5454 mL | |
| 20 mM | 0.1964 mL | 0.9818 mL | 1.9636 mL | 4.9091 mL | |
| 25 mM | 0.1571 mL | 0.7855 mL | 1.5709 mL | 3.9273 mL | |
| 30 mM | 0.1309 mL | 0.6545 mL | 1.3091 mL | 3.2727 mL | |
| 40 mM | 0.0982 mL | 0.4909 mL | 0.9818 mL | 2.4545 mL | |
| 50 mM | 0.0785 mL | 0.3927 mL | 0.7855 mL | 1.9636 mL | |
| 60 mM | 0.0655 mL | 0.3273 mL | 0.6545 mL | 1.6364 mL | |
| 80 mM | 0.0491 mL | 0.2455 mL | 0.4909 mL | 1.2273 mL | |
| 100 mM | 0.0393 mL | 0.1964 mL | 0.3927 mL | 0.9818 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.