1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. TCN 201

TCN 201 

Cat. No.: HY-13457
Handling Instructions

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDAR. TCN 201 antagonism is dependent on the GluN1-agonist concentration. TCN 201 allows pharmacological identification of native GluN2A-containing NMDAR populations.

For research use only. We do not sell to patients.

TCN 201 Chemical Structure

TCN 201 Chemical Structure

CAS No. : 852918-02-6

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Description

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDAR. TCN 201 antagonism is dependent on the GluN1-agonist concentration. TCN 201 allows pharmacological identification of native GluN2A-containing NMDAR populations[1].

IC50 & Target

NMDAR[1]

In Vitro

TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes[1].
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes[1].
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes[1].
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons[1].
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina[2].

In Vivo

TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats[3].

Molecular Weight

461.89

Formula

C₂₁H₁₇ClFN₃O₄S

CAS No.

852918-02-6

SMILES

O=C(NNC(C1=CC=CC=C1)=O)C2=CC=C(CNS(=O)(C3=CC=C(F)C(Cl)=C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TCN 201TCN201TCN-201iGluRIonotropic glutamate receptorsGluN1GluN2ANMDARInhibitorinhibitorinhibit

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