1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. TCN 201

TCN 201 

Cat. No.: HY-13457 Purity: 98.81%
Handling Instructions

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3).

For research use only. We do not sell to patients.

TCN 201 Chemical Structure

TCN 201 Chemical Structure

CAS No. : 852918-02-6

Size Price Stock Quantity
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3)[1][2].

IC50 & Target

pIC50: 6.8 (GluN1/GluN2A NMDA receptor)[1]

In Vitro

TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC50s of 6.8 and <4.3, respectively[1].
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes[2].
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes[2].
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes[2].
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons[2].
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.89

Formula

C₂₁H₁₇ClFN₃O₄S

CAS No.

852918-02-6

SMILES

O=C(NNC(C1=CC=CC=C1)=O)C2=CC=C(CNS(=O)(C3=CC=C(F)C(Cl)=C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (541.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1650 mL 10.8251 mL 21.6502 mL
5 mM 0.4330 mL 2.1650 mL 4.3300 mL
10 mM 0.2165 mL 1.0825 mL 2.1650 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.81%

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Keywords:

TCN 201TCN201TCN-201iGluRIonotropic glutamate receptorsGluN1GluN2ANMDARInhibitorinhibitorinhibit

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TCN 201
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