852918-02-6
852918-02-6
Chemical Structure
TCN 201
- CAS No.: 852918-02-6
- Formula:C21H17ClFN3O4S
- Molecular Weight:461.89
IUPAC Name: N-(4-(2-benzoylhydrazine-1-carbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamide
InChIKey: FYIBXBFDXNPBSF-UHFFFAOYSA-N
SMILES: O=C(NNC(C1=CC=CC=C1)=O)C2=CC=C(CNS(=O)(C3=CC=C(F)C(Cl)=C3)=O)C=C2
Biological Activity: TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TCN 201 | 98.08% | TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3). | ||||||||||||||||||||
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References
- [1]. Bettini E, et, al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther. 2010 Dec; 335(3): 636-44. [Content Brief]
- [2]. Edman S, et, al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep; 63(3): 441-9. [Content Brief]
Keywords
