1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

Rapastinel (Synonyms: GLYX-13; Thr-Pro-Pro-Thr-NH2)

Cat. No.: HY-16728 Purity: 99.49%
Data Sheet SDS Handling Instructions

Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.

For research use only. We do not sell to patients.
Rapastinel Chemical Structure

Rapastinel Chemical Structure

CAS No. : 117928-94-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $255 In-stock
1 mg $70 In-stock
5 mg $280 In-stock
10 mg $450 In-stock
25 mg $960 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Target: NMDA Rapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02192099 Naurex, Inc Major Depressive Disorder February 2015 Phase 2
NCT01684163 Naurex, Inc Major Depressive Disorder November 2012 Phase 2
NCT02267629 New York State Psychiatric Institute Obsessive-Compulsive Disorder (OCD) October 2014 Phase 2
NCT01844726 Northwestern University Learning and Memory in Healthy Individuals and Those With Psychiatric Illness May 2013 Phase 2
NCT01234558 Naurex, Inc Major Depressive Disorder May 2011 Phase 2
NCT01014650 Naurex, Inc Healthy November 2009 Phase 1
NCT03002077 Allergan Depressive Disorder, Major February 3, 2017 Phase 3
NCT02951988 Allergan Depressive Disorder, Major November 13, 2016 Phase 3
NCT02932943 Allergan Depressive Disorder, Major October 15, 2016 Phase 3
NCT02943577 Allergan Depressive Disorder, Major November 2, 2016 Phase 3
NCT02943564 Allergan Depressive Disorder, Major November 1, 2016 Phase 3
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.4186 mL 12.0928 mL 24.1856 mL
5 mM 0.4837 mL 2.4186 mL 4.8371 mL
10 mM 0.2419 mL 1.2093 mL 2.4186 mL
References
Molecular Weight

413.47

Formula

C₁₈H₃₁N₅O₆

CAS No.

117928-94-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Rapastinel
Cat. No.:
HY-16728
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