1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Rapastinel

Rapastinel  (Synonyms: GLYX-13)

Cat. No.: HY-16728
COA Handling Instructions

Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.

For research use only. We do not sell to patients.

Rapastinel Chemical Structure

Rapastinel Chemical Structure

CAS No. : 117928-94-6

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE Rapastinel


    Rapastinel purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Aug;24(16):9287-9299.  [Abstract]

    Neurons are pre-treated with 25 μM propofol plus 20 μM Rapastinel, followed by TNF-α treatment (40 ng/mL, 2 h). The effect of propofol on TNF-α- induced intracellular calcium accumulation, phosphorylation of CaMK II and calpain-2, calpain activation, cathepsin B release and TrkB truncation is counteracted by Rapastinel.
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    Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Target: NMDA Rapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices.

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    Sequence Shortening



    Room temperature in continental US; may vary elsewhere.

    Powder -80°C 2 years
    -20°C 1 year
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (77.39 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4186 mL 12.0928 mL 24.1856 mL
    5 mM 0.4837 mL 2.4186 mL 4.8371 mL
    10 mM 0.2419 mL 1.2093 mL 2.4186 mL
    *Please refer to the solubility information to select the appropriate solvent.
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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