1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Rapastinel

Rapastinel (Synonyms: GLYX-13)

Cat. No.: HY-16728 Purity: 99.49%
Handling Instructions

Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.

For research use only. We do not sell to patients.

Rapastinel Chemical Structure

Rapastinel Chemical Structure

CAS No. : 117928-94-6

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Rapastinel:

Other Forms of Rapastinel:

Top Publications Citing Use of Products

Publications Citing Use of MCE Rapastinel

    Rapastinel purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Jul 6.

    Neurons are pre-treated with 25 μM propofol plus 20 μM Rapastinel, followed by TNF-α treatment (40 ng/mL, 2 h). The effect of propofol on TNF-α- induced intracellular calcium accumulation, phosphorylation of CaMK II and calpain-2, calpain activation, cathepsin B release and TrkB truncation is counteracted by Rapastinel.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Target: NMDA Rapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices.

    Clinical Trial
    Molecular Weight

    413.47

    Formula

    C₁₈H₃₁N₅O₆

    CAS No.

    117928-94-6

    Sequence

    Thr-Pro-Pro-Thr-NH2

    Sequence Shortening

    TPPT-NH2

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (77.39 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4186 mL 12.0928 mL 24.1856 mL
    5 mM 0.4837 mL 2.4186 mL 4.8371 mL
    10 mM 0.2419 mL 1.2093 mL 2.4186 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    RapastinelGLYX-13GLYX13GLYX 13iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Rapastinel
    Cat. No.:
    HY-16728
    Quantity:
    MCE Japan Authorized Agent: