2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. iGluR
  4. SDZ 220-581

SDZ 220-581 

Cat. No.: HY-13059 Purity: 99.20%
COA Handling Instructions

SDZ 220-581 is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.

For research use only. We do not sell to patients.

SDZ 220-581 Chemical Structure

SDZ 220-581 Chemical Structure

CAS No. : 174575-17-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 198 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 768 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

SDZ 220-581 is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1].

IC50 & Target

pKi: 7.7 (NMDA receptor)[1]
In Vivo

SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male OF-l mice (18-26 g)[1]
Dosage: 3.2 mg/kg, 10 mg/kg, 32 mg/kg
Administration: Oral administration; for 24 hours
Result: Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.
Molecular Weight

369.74

Appearance

Solid

Formula

C16H17ClNO5P
CAS No.
SMILES

ClC1=CC=CC=C1C2=CC(C[[email protected]](N)C(O)=O)=CC(CP(O)(O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.57 mg/mL (23.18 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7046 mL 13.5230 mL 27.0460 mL
5 mM 0.5409 mL 2.7046 mL 5.4092 mL
10 mM 0.2705 mL 1.3523 mL 2.7046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.76 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SDZ 220-581174575-17-8iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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