1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Thiocolchicoside

Thiocolchicoside 

Cat. No.: HY-N0301 Purity: 99.23%
Handling Instructions

Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties.

For research use only. We do not sell to patients.

Thiocolchicoside Chemical Structure

Thiocolchicoside Chemical Structure

CAS No. : 602-41-5

Size Price Stock Quantity
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1].

IC50 & Target

GABAA) receptor; glycine receptor[1]

In Vitro

Thiocolchicoside (0.001, 0.1, 1, 10, 100 μM) reduces the amplitude of eIPSCs in a concentration-dependent manner with this effect being significant at 0.1 μM and maximal at 10 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

563.62

Formula

C₂₇H₃₃NO₁₀S

CAS No.

602-41-5

SMILES

CSC1=CC=C2C3=C(OC)C(OC)=C(O[[email protected]@H]4O[[email protected]](CO)[[email protected]@H](O)[[email protected]](O)[[email protected]]4O)C=C3CC[[email protected]](NC(C)=O)C2=CC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (443.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7742 mL 8.8712 mL 17.7425 mL
5 mM 0.3548 mL 1.7742 mL 3.5485 mL
10 mM 0.1774 mL 0.8871 mL 1.7742 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ThiocolchicosideGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorγ-aminobutyricacidGABAAglycinecentralnervoussystemmusclerelaxantanti-inflammatoryanalgesicInhibitorinhibitorinhibit

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Product Name:
Thiocolchicoside
Cat. No.:
HY-N0301
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