9(S)-HODE
Based on 1 Customer Validation
9(S)-HODE (Alpha-dimorphecolic acid) is the major active derivative of Linoleic acid (HY-N0729). 9(S)-HODE regulates the expression of miR-361-3p. 9(S)-HODE reduces cancer cell viability and induces cancer cell apoptosis. 9(S)-HODE can be used in the research of acute myeloid leukemia.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 73543-67-6
- Formula: C18H32O3
- Molecular Weight:296.44
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Storage:
Solution, -20°C, 2 years
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
9S-HODE (12.5-25 μM; 12-72 h) significantly downregulates the expression of miR-361-3p in HL-60 cells[1].
9S-HODE (25 μM; 0-72 h) inhibits the viability of HL-60 cells and induces apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human acute myeloid leukemia HL-60 cells
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Concentration:25 μM
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Incubation Time:12, 24, 36, 48, 72 h
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Result:Downregulated miR-361-3p expression in a time-dependent manner.
Increased BTG2 mRNA expression.
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Cell Line:human acute myeloid leukemia HL-60 cells
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Concentration:25 μM
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Incubation Time:48 h
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Result:Increased the percentages of early apoptotic (Annexin V+/PI-) and late apoptotic (Annexin V+/PI+) HL-60 cells compared to control.
Chemical Information
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CAS No. 73543-67-6
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Appearance Liquid
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Molecular Weight 296.44
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Formula C18H32O3
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
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Synonyms
Alpha-dimorphecolic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (265 KB)
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SDS (544 KB)
- English - EN (544 KB)
- Français - FR (544 KB)
- Deutsch - DE (544 KB)
- Norwegian - NO (544 KB)
- Español - ES (544 KB)
- Swedish - SV (544 KB)
- Italian - IT (544 KB)
- Korean - KR (544 KB)
- Portuguese - PT (544 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)