H2L 5765834
Based on 1 publication(s) in Google Scholar
H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.
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- Pureté : 98.66%
- CAS No.: 420841-84-5
- Formule: C21H12N2O7
- Masse moléculaire:404.33
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) H2L 5765834
More
Activité biologique
Description
IC50 & Target
[1]|
LPA1 Receptor 94 nM (IC50) |
LPA3 Receptor 752 nM (IC50) |
LPA5 Receptor 463 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RH7777 | IC50 |
463 nM
Compound: 20
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Antagonist activity at LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response
Antagonist activity at LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response
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[PMID: 19800804] |
| RH7777 | IC50 |
752 nM
Compound: 20
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Antagonist activity at LPA3 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response
Antagonist activity at LPA3 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response
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[PMID: 19800804] |
| RH7777 | IC50 |
94 nM
Compound: 20
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Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response
Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response
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[PMID: 19800804] |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 420841-84-5
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Appearance Solid
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Masse moléculaire 404.33
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Formule C21H12N2O7
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
In Vitro:
DMSO : 250 mg/mL (618.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284(25): 17304-19. [Content Brief]
[2]. Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49(12): e407. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4732 mL | 12.3661 mL | 24.7323 mL | 61.8307 mL |
| 5 mM | 0.4946 mL | 2.4732 mL | 4.9465 mL | 12.3661 mL | |
| 10 mM | 0.2473 mL | 1.2366 mL | 2.4732 mL | 6.1831 mL | |
| 15 mM | 0.1649 mL | 0.8244 mL | 1.6488 mL | 4.1220 mL | |
| 20 mM | 0.1237 mL | 0.6183 mL | 1.2366 mL | 3.0915 mL | |
| 25 mM | 0.0989 mL | 0.4946 mL | 0.9893 mL | 2.4732 mL | |
| 30 mM | 0.0824 mL | 0.4122 mL | 0.8244 mL | 2.0610 mL | |
| 40 mM | 0.0618 mL | 0.3092 mL | 0.6183 mL | 1.5458 mL | |
| 50 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2366 mL | |
| 60 mM | 0.0412 mL | 0.2061 mL | 0.4122 mL | 1.0305 mL | |
| 80 mM | 0.0309 mL | 0.1546 mL | 0.3092 mL | 0.7729 mL | |
| 100 mM | 0.0247 mL | 0.1237 mL | 0.2473 mL | 0.6183 mL |
H2L 5765834 Related Classifications
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