1. GPCR/G Protein
  2. LPL Receptor
  3. H2L 5765834

H2L 5765834 

Cat. No.: HY-15706
Handling Instructions

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.

For research use only. We do not sell to patients.

H2L 5765834 Chemical Structure

H2L 5765834 Chemical Structure

CAS No. : 420841-84-5

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Description

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1].

IC50 & Target[1]

LPA1 Receptor

94 nM (IC50)

LPA3 Receptor

752 nM (IC50)

LPA5 Receptor

463 nM (IC50)

In Vitro

H2L 5765834 displays no effect on LPA2 or LPA4 receptors[1].
H2L 5765834 inhibits LPA-induced platelet shape change with an IC50 of 13.73±2.52 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.33

Formula

C₂₁H₁₂N₂O₇

CAS No.

420841-84-5

SMILES

O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

H2L 5765834LPL ReceptorLysophospholipid ReceptorlysophosphatidicacidreceptorsLPAInhibitorinhibitorinhibit

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H2L 5765834
Cat. No.:
HY-15706
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