2. GPCR/G Protein
  3. LPL Receptor
  4. H2L 5765834

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.

For research use only. We do not sell to patients.

H2L 5765834 Chemical Structure

H2L 5765834 Chemical Structure

CAS No. : 420841-84-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid
1 mg USD 71 In-stock
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
100 mg USD 1350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

H2L 5765834 Related Antibodies

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1].

IC50 & Target[1]

LPA1 Receptor

94 nM (IC50)

LPA3 Receptor

752 nM (IC50)

LPA5 Receptor

463 nM (IC50)

In Vitro

H2L 5765834 displays no effect on LPA2 or LPA4 receptors[1].
H2L 5765834 inhibits LPA-induced platelet shape change with an IC50 of 13.73±2.52 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

H2L 5765834 Related Antibodies
In Vivo

H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

404.33

Formula

C21H12N2O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (618.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4732 mL 12.3661 mL 24.7323 mL
5 mM 0.4946 mL 2.4732 mL 4.9465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4732 mL 12.3661 mL 24.7323 mL 61.8307 mL
5 mM 0.4946 mL 2.4732 mL 4.9465 mL 12.3661 mL
10 mM 0.2473 mL 1.2366 mL 2.4732 mL 6.1831 mL
15 mM 0.1649 mL 0.8244 mL 1.6488 mL 4.1220 mL
20 mM 0.1237 mL 0.6183 mL 1.2366 mL 3.0915 mL
25 mM 0.0989 mL 0.4946 mL 0.9893 mL 2.4732 mL
30 mM 0.0824 mL 0.4122 mL 0.8244 mL 2.0610 mL
40 mM 0.0618 mL 0.3092 mL 0.6183 mL 1.5458 mL
50 mM 0.0495 mL 0.2473 mL 0.4946 mL 1.2366 mL
60 mM 0.0412 mL 0.2061 mL 0.4122 mL 1.0305 mL
80 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.7729 mL
100 mM 0.0247 mL 0.1237 mL 0.2473 mL 0.6183 mL
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H2L 5765834 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H2L 5765834420841-84-5LPL ReceptorLysophospholipid ReceptorlysophosphatidicacidreceptorsLPAInhibitorinhibitorinhibit

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