Isodeoxycholic acid
Based on 1 publication(s) in Google Scholar
Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is a 3β-hydroxylated secondary bile acid. Isodeoxycholic acid is produced by epimerization of deoxycholic acid by intestinal bacteria. Isodeoxycholic acid is detectable in feces, mainly existing as saponifiable conjugates with long-chain fatty acids. Isodeoxycholic acid participates in the regulation of intestinal physiology.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 566-17-6
- Formula: C24H40O4
- Molecular Weight:392.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Isodeoxycholic acid
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Isodeoxycholic acid (alkaline hydrolysis for 1 h) exists in human feces in two forms: free form and saponifiable (esterified) form[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 566-17-6
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Appearance Solid
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Molecular Weight 392.57
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Formula C24H40O4
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@]([C@@H](C[C@]1([H])CCCC2)O)([H])[C@@]4([H])[C@]([C@H](C3)O)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C
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Synonyms
7α,12α-Dihydroxycholanoic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomedicines
2025 Apr 4;13(4):874. PMID: 40299495
Solvent & Solubility
DMSO : 100 mg/mL (254.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5473 mL | 12.7366 mL | 25.4732 mL | 63.6829 mL |
| 5 mM | 0.5095 mL | 2.5473 mL | 5.0946 mL | 12.7366 mL | |
| 10 mM | 0.2547 mL | 1.2737 mL | 2.5473 mL | 6.3683 mL | |
| 15 mM | 0.1698 mL | 0.8491 mL | 1.6982 mL | 4.2455 mL | |
| 20 mM | 0.1274 mL | 0.6368 mL | 1.2737 mL | 3.1841 mL | |
| 25 mM | 0.1019 mL | 0.5095 mL | 1.0189 mL | 2.5473 mL | |
| 30 mM | 0.0849 mL | 0.4246 mL | 0.8491 mL | 2.1228 mL | |
| 40 mM | 0.0637 mL | 0.3184 mL | 0.6368 mL | 1.5921 mL | |
| 50 mM | 0.0509 mL | 0.2547 mL | 0.5095 mL | 1.2737 mL | |
| 60 mM | 0.0425 mL | 0.2123 mL | 0.4246 mL | 1.0614 mL | |
| 80 mM | 0.0318 mL | 0.1592 mL | 0.3184 mL | 0.7960 mL | |
| 100 mM | 0.0255 mL | 0.1274 mL | 0.2547 mL | 0.6368 mL |
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