2. Induced Disease Models Products Metabolic Enzyme/Protease
  3. Immunology and Inflammatory Disease Models Endogenous Metabolite
  4. Paw Edema Models
  5. Arachidonic acid sodium salt

Arachidonic acid sodium salt  (Synonyms: Immunocytophyt sodium salt)

Cat. No.: HY-109590A Purity: 99.0%
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Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function.

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CAS No. : 6610-25-9

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Customer Review

Based on 55 publication(s) in Google Scholar

Other Forms of Arachidonic acid sodium salt:

Arachidonic acid sodium salt Related Antibodies

Top Publications Citing Use of Products

55 Publications Citing Use of MCE Arachidonic acid sodium salt

Cell Imaging/Staining
Others
ELISA
WB
Cell Proliferation/Viability Assay

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805.  [Abstract]

    HCC1806 cells were serum starved for 16 hours and subsequently restimulated for 30 minutes with 1μM, 5μM, 10μM, 30μM, 100μM, 200μM, 1000μM of ω-6 LA, ω-6 ARA, ω-3 ALA, ω-3 EPA and ω-3 DHA for 30 minutes. Intracellular concentrations of each PUFA were quantified by ELISA from lysates obtained from 5 x 106 cells.

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805.  [Abstract]

    lmmunoblot analysis of HCC1806 cells following 16 hour serum starvation and subsequent stimulation with 10% FBS or 30 μM ω-6 LA or Arachidonic acid (AA), or ω-3 ALA, Eicosapentaenoic acid (EPA) or Docosahexaenoic acid (DHA) for 30 minutes.

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2025 May;6(5):768-785.  [Abstract]

    The cell viability of HT-1080 cells treated with IFNγ (20 ng/mL) plus Arachidonic acid (AA, 20 μM) in conjunction with or without 2-BP (10 μM) and Fer-1 (2 μM) for 48 h.

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2025 Oct 28:S0003-4967(25)04428-0.  [Abstract]

    ELISA analysis of PGE2 concentrations in the supernatants of wild-type (WT) and TBXAS1-knockout (KO) U937 cell lines treated with indicated doses of Arachidonic acid (0-25 μM).

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 29;16(1):8541.  [Abstract]

    BODIPY (green) and nuclei (red) staining of OVCAR8 cells treated with Arachidonic acid (70 μM) and embedded in 70 µm OHG for 7 d. Arrowheads indicate collectively-invading cells.

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 5;16(1):5209.  [Abstract]

    Representative images of live HeLa-Lyso-mKeima cells treated with DMSO or 100 μM Arachidonic acid for 15 min (left) and corresponding mKeima FLIs (right).

    Arachidonic acid sodium salt purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 and A2780 cells were cultured in fatty acid-free media supplemented with 50 μM AA (arachidonic acid), 50 μM OA (oleic acid), 50 μM EPA (eicosapentaenoic acid), 50 μM PA (Palmitic acid), and 50 μM MA (myristic acid) with the treatment of 10 μM niraparib for 72 h, and the cell viability was determined.

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    Description

    Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Arachidonic acid sodium salt can be used to induce paw edema models[2].

    Induction of Paw Edema Model[2]
    Background
    Principle: Injecting arachidonic acid into the hind paws of rats can induce rapid and sustained inflammatory responses.
    Specific Modeling Methods
    Rat: Lewis • male •
    Administration: 0.5% • s.c. • single dose
    Note
    A single subcutaneous injection of 0.10 mL of arachidonic acid (dissolved in 0.2 M carbonate buffer with a pH value of 8.43-8.56) was administered into the right hind paw of male Lewis rats weighing 144-241 grams.
    Modeling Indicators
    Appearance Monitoring: Significant edema became apparent within 5 minutes, and the reaction reached its peak at 1 hour after injection.
    Opposite Product(s): phenidone (HY-W010144); SK&F86002 (HY-12511)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Lew rats (4-week-old) induced arthritis[1]
    Dosage: 0.07%, 0.15% or 0.32% in diet (w/w)
    Administration: 4 weeks
    Result: The Arachidonic acid content of phospholipids in the paw was significantly elevated in a dose-dependent manner.
    Molecular Weight

    326.45

    Formula

    C20H31NaO2
    CAS No.
    Appearance

    Solid-Liquid Mixture

    Color

    White to yellow

    SMILES

    CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[Na])=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    Ethanol : 1 mg/mL (3.06 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0633 mL 15.3163 mL 30.6326 mL
    5 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.3%

    SDS (393 KB)

    COA (238 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol 1 mM 3.0633 mL 15.3163 mL 30.6326 mL 76.5814 mL
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    Arachidonic acid sodium salt Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Arachidonic acid6610-25-9ImmunocytophytEndogenous Metabolitepolyunsaturated fatty acidbiomembranescognitive responsecardiovascular functionInhibitorinhibitorinhibit

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