1. MAPK/ERK Pathway
  2. p38 MAPK
  3. SKF-86002

SKF-86002 

Cat. No.: HY-12511 Purity: 99.46%
Handling Instructions

SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.

For research use only. We do not sell to patients.

SKF-86002 Chemical Structure

SKF-86002 Chemical Structure

CAS No. : 72873-74-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1008 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid[1][2].

In Vitro

SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV)[1].
SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells[1].
SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: U937 cells
Concentration: 10 μM
Incubation Time: 72 hours
Result: Significantly reduced CD23 levels on IL-4-treated U937 cells.
In Vivo

SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats, with adjuvant-induced arthritis (AA)[4]
Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg
Administration: Oral administration, daily, for 22 days
Result: Decreased significantly hindleg.
Molecular Weight

297.35

Formula

C₁₆H₁₂FN₃S

CAS No.

72873-74-6

SMILES

FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (112.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3630 mL 16.8152 mL 33.6304 mL
5 mM 0.6726 mL 3.3630 mL 6.7261 mL
10 mM 0.3363 mL 1.6815 mL 3.3630 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SKF-86002SKF86002SKF 86002p38 MAPKanti-inflammatoryanti-arthriticanalgesiclipoxygenase5-lipoxygenasecyclooxygenasearachidonicacidmetabolismInhibitorinhibitorinhibit

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Product Name:
SKF-86002
Cat. No.:
HY-12511
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