1. MAPK/ERK Pathway
    Autophagy
    Apoptosis
  2. p38 MAPK
    Autophagy
    Apoptosis
  3. SB 202190 hydrochloride

SB 202190 hydrochloride 

Cat. No.: HY-10295A
Handling Instructions

SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity. SB202190 hydrochloride induces autophagy.

For research use only. We do not sell to patients.

SB 202190 hydrochloride Chemical Structure

SB 202190 hydrochloride Chemical Structure

CAS No. : 350228-36-3

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Description

SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3].

IC50 & Target[1]

p38α

50 nM (IC50)

p38β2

100 nM (IC50)

In Vitro

SB 202190 (0-10 μM; 0-72 hours) hydrochloride attenuates growth of a subgroup of CRC cell lines such as RKO, CACO2 and SW480 in a dose- and time-dependent manner[1].
SB 202190 hydrochloride strongly inhibited colony formation and anchorage-independent growth (10 μM for 7-10 days) and elevated apoptotic cell death (10 μM for 72 h) in this same subset of CRC lines (RKO, CACO2 and SW480)[2].
In RKO, CACO2 and SW480 cells, SB 202190 (10 μM; 2 hours) hydrochloride abrogates phosphorylation of S6K1(T389) and S6(S235/236), but not AKT(S473), indicating that p38i selectively blocks mTORC1 signaling[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 202190 (5 mg/kg; intraperitoneal injection; daily for 10-12 days) hydrochloride shows inhibition of tumor cell survival and tumor growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.80

Formula

C₂₀H₁₅ClFN₃O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
SB 202190 hydrochloride
Cat. No.:
HY-10295A
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