1. GPCR/G Protein
  2. Cholecystokinin Receptor
  3. Gastrin-1, human

Gastrin-1, human 

Cat. No.: HY-P1097 Purity: 98.41%
Handling Instructions

Gastrin-1, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.

For research use only. We do not sell to patients.

Gastrin-1, human Chemical Structure

Gastrin-1, human Chemical Structure

CAS No. : 10047-33-3

Size Price Stock Quantity
1 mg USD 130 In-stock
Estimated Time of Arrival: December 31
5 mg USD 520 In-stock
Estimated Time of Arrival: December 31
10 mg USD 820 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Gastrin-1, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.

IC50 & Target

CCK2 receptor[1]

In Vitro

Gastrin-1, human is the endogenous peptide produced in the stomach, and acts via cholecystokinin 2 (CCK2) receptor[1].

In Vivo

Gastrin-1 (1.5, 5, 15 and 45 nmol/kg, i.v.) increases pepsinogen and acid secretion in rats[1].

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (23.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4766 mL 2.3830 mL 4.7660 mL
5 mM 0.0953 mL 0.4766 mL 0.9532 mL
10 mM 0.0477 mL 0.2383 mL 0.4766 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats[1]
The first set of experiments is carried out on rats with intact vagus nerves which are acutely treated with CCK-8S or Gastrin-1 at the doses of 1.5, 5, 15 and 45 nmol/kg. Both these peptides are administered i.v. as a bolus immediately after the collection of basal effluent samples. In experiments investigating the involvement of muscarinic, histamine H or CCK receptors in the gastric 2 secretory responses elicited by CCK-8S or Gastrin-1, the animals are pretreated with atropine 1 μmol/kg i.v., cimetidine 10 μmolrkg i.v., devazepide 1.25-2.5 μmol/kg i.v. or L-365,260 2.5-5 μmol/kg i.v., 10 min before ending the collection of the second basal effluent sample. Additional experiments are performed in animals pretreated with the irreversible inhibitor of histidine decarboxylase, α-fluoromethylhistidine (450 mmol/kg i.p. twice daily for two consecutive days), in order to suppress endogenous histamine production from digestive enterochromaffin-like cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2098.20

Formula

C₉₇H₁₂₄N₂₀O₃₁S

CAS No.

10047-33-3

Sequence

{pGlu}-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Sequence Shortening

{pGlu}-GPWLEEEEEAYGWMDF-NH2

SMILES

[pE-GPWLEEEEEAYGWMDF-NH2]

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.41%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Gastrin-1, human
Cat. No.:
HY-P1097
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Gastrin-1, human

Cat. No.: HY-P1097