CCKBR

The cholecystokinin B receptor also known as CCKBR or CCK2R. CCK2R is a G protein-coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. CCK2R has a high affinity for both gastrin and its COOH amidated analogues longer than the tetrapeptide, as well as cholecystokinin(CCK).CCK2R is found principally in the central nervous system and the gastrointestinal tract.

CCKBR Related Products (5):

By Type:	Selective (1)
By Effects:	Antagonists (3) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-P1097

Gastrin I, human		99.93%
Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.

HY-A0261

Pentagastrin	Activator	99.97%
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCK_B) receptor antagonists with IC₅₀ values of 11 nM and 1100 nM for CCK_B and CCK_A, respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..

HY-106840

L-365260	Antagonist	99.93%
L-365260 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with K_is of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance.

HY-129810

PD 135158	Antagonist
PD 135158 (CAM 1028) is a selective CCK_B receptor antagonist with an IC₅₀ of 2.8 nM against mouse cortex CCK_B. PD 135158 shows anxiolytic activity.

HY-111313

JNJ-26070109	Antagonist
JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pK_is of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the research of gastroesophageal reflux disease.

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