1. GPCR/G Protein
  2. Cholecystokinin Receptor

Nastorazepide (Synonyms: Z-360)

Cat. No.: HY-17617 Purity: 99.78%
Data Sheet SDS Handling Instructions

Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.

For research use only. We do not sell to patients.
Nastorazepide Chemical Structure

Nastorazepide Chemical Structure

CAS No. : 209219-38-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $401 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Target:CCK-2 in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02117258 Zeria Pharmaceutical Metastatic Pancreatic Adenocarcinoma April 2014 Phase 2
NCT01776463 Zeria Pharmaceutical Healthy Volunteers January 2013 Phase 1
NCT00288925 Zeria Pharmaceutical Pancreatic Cancer September 2005 Phase 1|Phase 2
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.9208 mL 9.6039 mL 19.2079 mL
5 mM 0.3842 mL 1.9208 mL 3.8416 mL
10 mM 0.1921 mL 0.9604 mL 1.9208 mL
References
Molecular Weight

520.62

Formula

C₂₉H₃₆N₄O₅

CAS No.

209219-38-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Nastorazepide
Cat. No.:
HY-17617
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