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Nastorazepide Chemical Structure
|Product name: Nastorazepide|
|Cat. No.: HY-17617|
Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.
in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent.
in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.
|M.Wt||520.62||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 32 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||1.9208 mL||9.6039 mL||19.2079 mL|
|5 mM||0.3842 mL||1.9208 mL||3.8416 mL|
|10 mM||0.1921 mL||0.9604 mL||1.9208 mL|