1. GPCR/G Protein
    Neuronal Signaling
  2. Cholecystokinin Receptor
  3. CCK-B Receptor Antagonist 2

CCK-B Receptor Antagonist 2 

Cat. No.: HY-129357 Purity: 98.84%
Handling Instructions

CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM.

For research use only. We do not sell to patients.

CCK-B Receptor Antagonist 2 Chemical Structure

CCK-B Receptor Antagonist 2 Chemical Structure

CAS No. : 155412-88-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].

IC50 & Target

IC50: 0.43 nM (Gastrin/CCK-B); 1.82 μM (Gastrin/CCK-A)[1]

In Vivo

CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1].

Molecular Weight

484.55

Formula

C₂₇H₂₈N₆O₃

CAS No.

155412-88-7

SMILES

O=C(N[[email protected]]1C(N(CC(C(C)(C)C)=O)C2=CC=CC=C2C(C3=NC=CC=C3)=N1)=O)NC4=CC=CC(N)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (515.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0638 mL 10.3189 mL 20.6377 mL
5 mM 0.4128 mL 2.0638 mL 4.1275 mL
10 mM 0.2064 mL 1.0319 mL 2.0638 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.29 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CCK-B Receptor Antagonist 2Cholecystokinin ReceptorCCK ReceptorgastricacidsecretionCCKBInhibitorinhibitorinhibit

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Product Name:
CCK-B Receptor Antagonist 2
Cat. No.:
HY-129357
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