176915-07-4
176915-07-4
Chemical Structure
TP-680
- CAS No.: 176915-07-4
- Formula:C35H33N5O4S
- Molecular Weight:619.73
IUPAC Name: (R)-2-((3-(4-benzhydrylpiperazin-1-yl)-2-(1H-indole-2-carboxamido)-3-oxopropyl)thio)nicotinic acid
InChIKey: JWXZKQOPZVEJHR-PMERELPUSA-N
SMILES: O=C(O)C1=CC=CN=C1SC[C@@H](C(N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)NC(C5=CC6=C(C=CC=C6)N5)=O
Biological Activity: TP-680 is a cholecystokinin receptor antagonist. TP-680 binds 1510 times more strongly to rat pancreatic CCKA receptors (IC50=1.2 nM) than to rat brain CCKB receptors (IC50=1812.5 nM). TP-680 can be used in the study of gastrointestinal diseases[1].
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TP-680 | TP-680 is a cholecystokinin receptor antagonist. TP-680 binds 1510 times more strongly to rat pancreatic CCKA receptors (IC50=1.2 nM) than to rat brain CCKB receptors (IC50=1812.5 nM). TP-680 can be used in the study of gastrointestinal diseases. | |||||||||||||||||||||
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