844645-08-5
Chemical Structure
JNJ-26070109
- CAS No.: 844645-08-5
- Formula:C23H17BrF2N4O3S
- Molecular Weight:547.37
IUPAC Name: (R)-4-bromo-N-(1-(2,4-difluorophenyl)ethyl)-2-(quinoxaline-5-sulfonamido)benzamide
InChIKey: TZKCPFFVWLRNRZ-CYBMUJFWSA-N
SMILES: O=C(N[C@@H](C1=CC=C(F)C=C1F)C)C2=CC=C(Br)C=C2NS(=O)(C3=C4N=CC=NC4=CC=C3)=O
Biological Activity: JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pKis of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the research of gastroesophageal reflux disease[1].
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JNJ-26070109 | 99.25% | JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pKis of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the research of gastroesophageal reflux disease. | ||||||||||||||||||||
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Keywords
