1. GPCR/G Protein
    Neuronal Signaling
  2. Cholecystokinin Receptor
  3. JNJ-26070109

JNJ-26070109 

Cat. No.: HY-111313
Handling Instructions

JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pKis of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the treatment of gastroesophageal reflux disease.

For research use only. We do not sell to patients.

JNJ-26070109 Chemical Structure

JNJ-26070109 Chemical Structure

CAS No. : 844645-08-5

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Description

JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pKis of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the treatment of gastroesophageal reflux disease[1].

IC50 & Target

pKi: 8.49 (human CCK2), 7.99 (rat CCK2), 7.70 (dog CCK2)[1]

Molecular Weight

547.37

Formula

C23H17BrF2N4O3S

CAS No.
SMILES

O=C(N[[email protected]@H](C1=CC=C(F)C=C1F)C)C2=CC=C(Br)C=C2NS(=O)(C3=C4N=CC=NC4=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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JNJ-26070109
Cat. No.:
HY-111313
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