2. Gastrazole

Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer.

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Gastrazole Chemical Structure

Gastrazole Chemical Structure

CAS No. : 862583-15-1

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Gastrazole Related Antibodies

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Description

Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2].

IC50 & Target

CCK2/gastrin receptor[1]
In Vivo

Gastrazole (0.15-3 μmol/kg; i.v.) dose-dependently inhibits the Pentagastrin-stimulated gastric acid secretion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats with a gastric fistula[2]
Dosage: 0.15, 0.3, 3 mg/kg
Administration: Intravenous administration
Result: Dose-dependently inhibited Pentagastrin-stimulation acid secretion by maximally 73%.
Molecular Weight

687.63

Formula

C34H32FN5Na2O7
CAS No.
SMILES

O=C(C(C=C(NC=N1)C1=C2)=C2C(NCC3CCCCCC3)=O)N[C@H](C(NC4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)=O)CC(C=CC=C5)=C5F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gastrazole862583-15-1JB95008JB 95008JB-95008Inhibitorinhibitorinhibit

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