1. MAPK/ERK Pathway
  2. p38 MAPK
  3. SKF-86002 dihydrochloride

SKF-86002 dihydrochloride 

Cat. No.: HY-108641
Handling Instructions

SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.

For research use only. We do not sell to patients.

SKF-86002 dihydrochloride Chemical Structure

SKF-86002 dihydrochloride Chemical Structure

CAS No. : 116339-68-5

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Description

SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid[1][2][3].

In Vitro

SKF-86002 dihydrochloride (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV)[1].
SKF-86002 dihydrochloride does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells[1].
SKF-86002 dihydrochloride (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[4]

Cell Line: U937 cells
Concentration: 10 μM
Incubation Time: 72 hours
Result: Reduced CD23 levels on IL-4-treated U937 cells.
In Vivo

SKF-86002 dihydrochloride (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats, with adjuvant-induced arthritis (AA)[5]
Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg
Administration: Oral administration, daily, for 22 days
Result: Significantly decreased hindleg volumes after injection of adjuvant.
Molecular Weight

370.27

Formula

C₁₆H₁₄Cl₂FN₃S

CAS No.
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Product Name:
SKF-86002 dihydrochloride
Cat. No.:
HY-108641
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