1. MAPK/ERK Pathway
  2. p38 MAPK

SB 239063 

Cat. No.: HY-11068 Purity: 99.53%
Handling Instructions

SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α).

For research use only. We do not sell to patients.

SB 239063 Chemical Structure

SB 239063 Chemical Structure

CAS No. : 193551-21-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 816 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Top Publications Citing Use of Products

    SB 239063 purchased from MCE. Usage Cited in: Int Immunopharmacol. 2016 Sep;38:54-60.

    The protective role of p38 MAPK inhibition in II/R-induced ALI and regulation of AQP4 in rats. HE staining and Lung wet/dry weight ratio show obvious evidences of ALI and lung edema. Western blot and immunofluorescent staining confirm the increased expression levels of AQP4 and P-p38 MAPK protein in the lung tissues. Then, the p38 MAPK inhibitor is administrated intraperitoneally. Results show that p38 MAPK inhibition downregulates AQP4 expression in the lungs and protected lung from acute injur

    SB 239063 purchased from MCE. Usage Cited in: Front Pharmacol. 2017 Nov 14;8:808.

    Immunofluorescence staining of α-actinin and the cell surface area of cardiomyocytes in the indicated groups (n=5 samples and n=100+cells per group).

    SB 239063 purchased from MCE. Usage Cited in: China Biotechnology. 2017, 37(12): 40-48.

    The Western blot analysis of HOG1 and Phospho-HOG1.

    SB 239063 purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Jun 28;37(1):128.

    MHCC-97H cells are transfected with control or supervillin-specific siRNA for 48 h, exposed to hypoxia for 16 h, and lysates are assayed for the relative amounts of GTP-loaded (activated) Rac1, Cdc42, and RhoA. Cells that have been transfected with control RNAi are treated with a PD0325901 or SB239063 before assaying for GTP-Rac1, Cdc42, and RhoA levels.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. IC50 value: 44 nM ( p38α) Target: p38 MAPK SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (90.47 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

    References
    Molecular Weight

    368.40

    Formula

    C₂₀H₂₁FN₄O₂

    CAS No.

    193551-21-2

    SMILES

    COC1=NC=CC(C2=C(N=CN2[[email protected]]3CC[[email protected]](O)CC3)C4=CC=C(F)C=C4)=N1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    SB 239063
    Cat. No.:
    HY-11068
    Quantity:

    SB 239063

    Cat. No.: HY-11068